B-Cell lymphoma at the site of pacemaker generator

Keyser, Andreas; Schopka, Simon; Stadlbauer, Andrea; Zerdzitzki, Matthaeus; Jungbauer, Carsten; Schmid, Çhristof

doi:10.1016/j.hrcr.2020.05.013

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…FA-DLBCL, considered a subtype of CI-DLBCL in the WHO-4R [ 1 ] and by the ICC [ 5 ], has been recognized as a distinct entity in the WHO-5 [ 4 ]. It consists of non-mass-forming aggregates of large atypical lymphoid cells in a background of debris or fibrin, usually encountered incidentally in confined, natural, or acquired spaces such as cardiac myxomas, chronic hematomas, thrombi, cardiovascular prosthetic devices [ 48 – 50 ], cysts and pseudocyst cavities (including those forming around breast implants) [ 48 , 51 , 52 ], and pacemakers [ 53 , 54 ]. Tumor cells may focally infiltrate the adjacent stroma (myxomatous or fibrotic) but not the pre-existing normal tissues.…”

Section: Fibrin-associated Dlbcl (Fa-dlbcl)mentioning

confidence: 99%

Cavity-based lymphomas: challenges and novel concepts. A report of the 2022 EA4HP/SH lymphoma workshop

Napoli

Soma

Quintanilla-Martı́nez

et al. 2023

Virchows Arch

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The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion. All entities above are discussed; however, three are delved into greater detail given the challenges with classification: ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. Cases exemplifying the diagnostic difficulty in differentiating ECPEL from HHV8-positive diffuse large B-cell lymphoma and germinotropic lymphoproliferative disorder were discussed. The more recently recognized effusion-based HHV8-negative large B-cell lymphoma is explored, with several cases submitted raising the question if this subset should be carved out as a specific entity, and if so, what should be the refining diagnostic criteria. Case submissions to the FA-DLBCL section yielded one of the largest case series to date, including classic cases, cases furthering the discussion on disease sites and prognosis, as well as novel concepts to be considered in this entity. The 2022 EA4HP/SH workshop cases allowed for further confirmation of the characteristics of some of the more historically accepted cavity-based lymphomas, as well as further inquiry and debate on relatively new or evolving entities.

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