B-Cell Lymphoma in the Peripheral Nerves of a Cat

Higgins, Michael A.; Rossmeisl, John H.; Saunders, Geoff; Hayes, Schantel; Kiupel, Matti

doi:10.1354/vp.45-1-54

Cited by 19 publications

(40 citation statements)

References 10 publications

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“…The gross findings often diverge from the common lymphoma presentation in other organs (Linzmann et al 2009). Lymphoma is the main secondary tumor in the feline CNS and neurolymphomatosis is a rare condition in cats, other animals, and humans (Allen & Amis 1975, Hankenson et al 1998, Kuntzer et al 2000, Mellanby et al 2003, Higgins et al 2008, Choi et al 2013, Shree et al 2016. The neoplastic infiltration in leptomeninges (leptomeningeal lymphomatosis) and perivascular space from medullar parenchyma, as observed in the present study, is a common consequence relative to spinal nerve neurolymphomatosis (Lane et al 1994, Schaffer et al 2012, Mandrioli et al 2012, Rupp et al 2014, Sakurai et al 2016.…”

Section: Discussionsupporting

confidence: 61%

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Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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ISSN 0100-736X (Print) ISSN 1678-5150 (Online) RESUMO.-[Linfoma no sistema nervoso de felinos: aspectos patológicos, imuno-histoquímicos e etiológicos em 16 gatos.] Os aspectos patológicos, imuno-histoquímicos (IHQ) e etiológicos do linfoma envolvendo o sistema nervoso de felinos foram analisados através de um estudo retrospectivo (período de 2004-2017) no Estado do Rio Grande do Sul, Brasil. O envolvimento do sistema nervoso foi observado em 16 (12,2%) dos 125 felinos com linfoma desse estudo e afetou principalmente, jovens com idade mediana de 24 meses. A grande maioria dos casos o linfoma era secundário no sistema nervoso central e somente em três gatos o linfoma foi primário do sistema nervoso. Na IHQ, 14 (87,5%) casos foram positivos para FeLV, seis (37,5%) para FIV, e um foi negativo para ambos. A distribuição do linfoma no sistema nervoso foi em 8/16 felinos na medula espinhal, 7/16 no encéfalo e em 1/16 em nervos e gânglios paravertebrais (neurolinfomatose). Na medula espinhal, o padrão do linfoma foi exclusivamente extradural e frequentemente focal (6/8), localizadas nos segmentos lombares (3/6), sacrais (1/6), torácicos (1/6) e cervicais (1/6). No encéfalo, os padrões neuroanatômicos observados foram: linfomatose leptomeningeal (4/7), coroidite linfomatosa (2/7), linfoma intradural (1/7). ABSTRACT.-Mello L.S., Leite-Filho R.V., Panziera W., Bandinelli M.B., Sonne L., Driemeier D. & Pavarini S.P. 2019. Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats. Pesquisa Veterinária Brasileira 39(6):393-401.

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Section: Discussionsupporting

confidence: 61%

“…The unusual feature of this condition can lead to confusion with other neurological conditions, such as vasculitis and mononeuritis (Mandrioli et al 2012). PNS lymphoma in humans and animals is often identified as B-cell (Higgins et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

et al. 2019

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“…Most human neurolymphomatoses have been reported to be caused by B-cell lymphomas when classified by the Revised European American Lymphoma or World Health Organization system [ 4 , 5 ]. In animals, neurolymphomatosis is also very rare [ 6 , 8 , 9 , 10 , 11 , 13 ]. To our knowledge, only three cats have been reported as neurolymphomastosis [ 6 , 9 , 10 ].…”

mentioning

confidence: 99%

Neurolymphomatosis in a cat

Sakurai

Azuma

Nagai³

et al. 2016

The Journal of Veterinary Medical Science

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A 9-year-old male mixed breed cat showed chronic progressive neurological symptoms, which are represented by ataxia and seizures. At necropsy, spinal roots and spinal ganglions at the level of sixth cervical nerve to second thoracic nerve were bilaterally swollen and replaced by white mass lesions. Right brachial plexus and cranial nerves (III, V and VII) were also swollen. A mass lesion was found in the right frontal lobe of the cerebrum. Histologically, neoplastic lymphocytes extensively involved the peripheral nerves, and they infiltrated into the cerebral and spinal parenchyma according to the peripheral nerve tract. Immunohistochemically, most neoplastic lymphocytes were positive for CD20. The clinical and histological features in this case resemble those of neurolymphomatosis in humans.

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“…Currently, only seven cases of feline neurolymphomatosis have been reported (Zaki and Hurvitz, 1976;Mellanby et al, 2003;Higgins et al, 2008;Linzmann et al, 2009;Mandrioli et al, 2012;Sakurai et al, 2016). The comparison between previously reported cases of feline neurolymphomatosis and the present case is shown in Supplementary Table 1.…”

mentioning

confidence: 79%

“…The most commonly affected nerves were the C5 to T2 spinal nerve roots (7/8) and their descending brachial plex-uses (6/8), which often led to the clinical sign of weight-bearing or non-weight-bearing lameness of the forelimbs. Only one case showed enlargement of the brachial plexus and sciatic nerve without involvement of the spinal nerve roots (Higgins et al, 2008). Multiple cranial nerves (III, V and VIII) were involved in two cases and led to the absence of ocular reflexes.…”

mentioning

confidence: 92%

CD56+ B-cell Neurolymphomatosis in a Cat

Tsai

Lee

Kao

et al. 2019

Journal of Comparative Pathology

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A 16-year-old male Russian blue cat was presented with acute onset of paraparesis of the forelimbs that progressed to tetraparesis. Neurological examination revealed non-ambulatory tetraparesis with decreased postural reactions in all four limbs. Magnetic resonance imaging revealed multifocal nerve root swelling on the right at C6/C7 and C7/T1, while ultrasonography demonstrated swelling of the right brachial plexus. To understand the cause of the nerve swelling, the right musculocutaneous nerve arising from the brachial plexus and the pectoralis muscle were biopsied. Histologically, there was evidence of neurolymphomatosis (neurotropic lymphoma) with Wallerian degeneration and denervation atrophy of myofibres. The neoplastic lymphoid cells expressed CD79a, CD20 and CD56. Based on these findings, a diagnosis of B-cell neurolymphomatosis was made. Expression of CD56, synonymous with neural cell adhesion molecule, is rare in B-cell lymphomas and has not been reported in feline B-cell lymphomas or feline neurolymphomatosis. CD56 expression was suspected to have played an important role in neurotropism of the neoplastic cells in this case.

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B-Cell Lymphoma in the Peripheral Nerves of a Cat

Cited by 19 publications

References 10 publications

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

Feline lymphoma in the nervous system: pathological, immunohistochemical, and etiological aspects in 16 cats

Neurolymphomatosis in a cat

CD56+ B-cell Neurolymphomatosis in a Cat

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