B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology

Carbone, Antonino; Gloghini, Annunziata; Aiello, Antonella; Testi, Maria Adele; Cabras, Antonello D.

doi:10.1016/j.humpath.2009.10.027

Cited by 59 publications

(44 citation statements)

References 50 publications

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“…Our results are in accordance with those reported by the literature in which this subtype is rare in pediatric population with a prevalence comprising about 10% [39,40].…”

Section: Non-hodgkin Lymphomas and Children supporting

confidence: 93%

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Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Budiongo

Ngiyulu

Lebwaze

et al. 2015

Pediatric Hematology and Oncology

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“…Our results are in accordance with those reported by the literature in which this subtype is rare in pediatric population with a prevalence comprising about 10% [39,40].…”

Section: Non-hodgkin Lymphomas and Children supporting

confidence: 93%

“…Considering the mature B-cell NHLs in the present cohort, BL corresponded to 56.3%, a much higher frequency than the western countries series in which the prevalence varies between 40% and 47% [1,38,39] and in Brazil in which the prevalence was found to be 37% of cases [36].…”

Section: Non-hodgkin Lymphomas and Children contrasting

confidence: 51%

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Budiongo

Ngiyulu

Lebwaze

et al. 2015

Pediatric Hematology and Oncology

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“…They represent a continuum between two or more well-characterized clinicopathological entities and show an overlap of morphological, immunophenotypic and molecular features that are traditionally used to separate Hodgkin lymphoma from nonHodgkin, large B-cell lymphomas. [1][2][3] The two recognized members of 'gray zone lymphoma' include those that show features intermediate between primary mediastinal large B-cell lymphoma and classical Hodgkin lymphoma, and diffuse large B-cell lymphoma and Burkitt lymphoma. [3][4][5][6][7] The overlap between primary mediastinal large B-cell lymphoma and classical Hodgkin lymphoma has been recognized for some time under the terms 'mediastinal gray zone lymphoma', 3,5 or 'large B-cell lymphoma with Hodgkin-like features'.…”

mentioning

confidence: 99%

The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases

2012

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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, is a diagnostic provisional category in the World Health Organization (WHO) 2008 classification of lymphomas. This category was designed as a measure to accommodate borderline cases that cannot be reliably classified into a single distinct disease entity after all available morphological, immunophenotypical and molecular studies have been performed. Typically, these cases share features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma, or include characteristics of both lymphomas. The rarity of such cases poses a tremendous challenge to both pathologists and oncologists because its differential diagnosis has direct implications for management strategies. In this study, we present 10 cases of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma and have organized the criteria described by the WHO into four patterns along with detailed clinical, morphological and immunophenotypic characterization and outcome data. Our findings show a male preponderance, median age of 37 years and a mediastinal presentation in 80% of cases. All cases expressed at least two markers associated with B-cell lineage and good response to combination chemotherapy currently employed for non-Hodgkin lymphomas.

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“…Some has immunophenotype consistent with BL but with variable nuclear size. However it should be emphasized that cases which are morphologically DLBCL with high proliferation index is not included in this category [1,4].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of B Cell Lymphomas, Unclassifiable; with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma in a Tertiary Care Hospital in Southern India

Selvi

Kar

Basu

et al. 2015

Indian J Hematol Blood Transfus

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(2008) to overcome the problems of difficulty in classifying certain lymphomas having overlapping morphological, immunophenotypical and genetic features. To study the clinicopathological profile of BCLu-DLBCL/BL. Crosssectional study over 3 year period in the Haematology section of Department of Pathology in a large teaching hospital in Southern India from January 2011 to December 2013. All the cases reported as BCLu-DLBCL/BL were collected and the clinical, morphological and immunohistochemical parameters were analyzed. Descriptive statistics. There were seven cases, four males and three females, of age ranging from 20 to 70 years. Five cases had extranodal involvement. Four cases had Burkitt morphology with strong Bcl2 positivity and absent CD10 expression. One case had the morphology and immunophenotype that of typical BL, along with strong positivity to Bcl2 suggesting a double hit hypothesis. Two cases had morphology and immunophenotype of BL with low Ki 67. Three patients on follow up had adverse outcome. BCLu-DLBCL/BL, a provisional category in WHO 2008 is useful in classifying the cases not meeting the criteria for classical BL or DLBCL. Each of these cases was interesting with different sites of involvement, different morphological features and immunophenotype with most of the patients on follow up ending with a grave prognosis.

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B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology

Cited by 59 publications

References 50 publications

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

Pediatric Non-Hodgkin Lymphomas: First Report from Central Africa

The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases

Clinicopathological Analysis of B Cell Lymphomas, Unclassifiable; with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma in a Tertiary Care Hospital in Southern India

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