B-cell peripheral neurolymphomatosis: MRI and 18F-FDG PET/CT imaging characteristics

DeVries, A.; Howe, Benjamin M.; Spinner, Robert J.; Broski, Stephen M.

doi:10.1007/s00256-019-3145-3

Cited by 38 publications

(37 citation statements)

References 26 publications

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“…However, abnormal neurophysiology may be purely related to distal Wallerian degeneration secondary to NL rather than direct lymphomatous infiltration, rendering the biopsy histopathologically abnormal, but not displaying evidence of NL. Radiology can often provide detail for lesion biopsies, 24 but such biopsies may be technically difficult without causing significant motor and sensory deficits.…”

Section: Discussionmentioning

confidence: 99%

Peripheral nerve neurolymphomatosis: Clinical features, treatment, and outcomes

et al. 2020

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This series characterises nine patients with neurohistopathologically proven peripheral nerve neurolymphomatosis. A search of the hospital neuropathology database from 2002 to 2019 identified biopsy proven cases. Clinical data, investigation modalities, treatments, and outcomes were collated. Median age at neuropathy onset was 47 y, the neuropathy commonly as the initial lymphoma disease manifestation. Most (8/9) presented with painful asymmetrical sensory disturbance, with additional cranial nerve involvement in three. Neurophysiology typically demonstrated multiple axonal mononeuropathies. Cerebrospinal fluid protein was often raised (6/8). Magnetic resonance imaging suggested peripheral nerve infiltration in 6/9 and positron emission tomography CT in 4/9. Bone marrow biopsy was abnormal in 6/8. Treatment involved systemic or intrathecal chemotherapy and radiotherapy. Median survival was 23 mo. Neurolymphomatosis is a rare but important cause of neuropathy, particularly in those lacking systemic evidence of lymphoma as correct aggressive treatment can prolong survival. Nerve biopsy is essential to classify lymphoma type and rule out alternatives.

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Section: Discussionmentioning

confidence: 99%

Peripheral nerve neurolymphomatosis: Clinical features, treatment, and outcomes

et al. 2020

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“…DWI is a magnetic resonance functional imaging technique based on the diffusion motion of water molecules in the living body, and with the application of MRI ultrafast imaging sequences, especially planar echo imaging sequences, DWI has been gradually applied to abdominal imaging diagnosis. The kidney is located in the retroperitoneal space and is relatively unaffected by respiratory motion, and the same satisfactory image quality can be obtained with free breathing as with breath-holding [ 22 – 24 ]. DWI signal intensity mainly reflects the tissue structure, nucleoplasmic ratio, distribution of water molecules inside and outside the cells, cell density, and so forth.…”

Section: Related Workmentioning

confidence: 99%

CT Imaging Characteristics and Influence Factors of Renal Dialysis-Associated Peritoneal Injury

Tong

2021

Journal of Healthcare Engineering

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Peritoneal dialysis (PD), as one of the main renal replacement modalities for end-stage renal disease, gets the advantages of better protection of residual renal function and better quality of survival. However, ultrafiltration failure after peritoneal injury is an important reason for patients to withdraw from PD treatment. Peritonitis is a major complication of peritoneal dialysis, which results in an accelerated process of peritoneal injury due to direct damage from acute inflammation and local release of cytokine TGF-β. In this paper, the application of ultrasound to examine the peritoneum revealed a positive correlation between peritoneal thickness and the development of peritonitis. The results of this study also further confirmed the effect of peritonitis on peritoneal thickening. A multifactorial regression analysis also revealed that peritonitis and its severity were independent risk factors for peritoneal thickening and omental structural abnormalities. This paper reported a correlation between mural peritoneal thickness and peritoneal transit function. In this study, patients with high peritoneal transit and high mean transit were found to be more prone to omental structural abnormalities than patients with low mean and low transit and a higher proportion of patients with mural peritoneal thickening, but this did not reach statistical significance, which may be related to the still small number of cases.

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“…MRI is another useful imaging tool for evaluating peripheral nerves. NL findings include diffuse or nodular thickening of nerves, T2 prolongation, and abnormal enhancement of nerve lesions [3,8]. We did not include these findings because recent studies of NL have reported diagnostic accuracies of 59-77% for MRI, which is inferior to those of 18 F-FDG PET/CT, which have been reported to be 84-100% [1,9].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is value in using 18 F-FDG PET/CT and MRI in combination in clinical settings and comparing the combined data with clinical information. Furthermore, flow cytometry, immunoglobulin heavy chain rearrangement, and microRNA are other new methods that have the potential to be useful in the diagnosis of CNS lesions, but their usefulness in the detection of peripheral nerve lesions has not yet been reported [1,7,8,20,21]. In the future, it will be important to compare these and 18 F-FDG PET/CT and/or MRI findings to detect biomarkers related to the diagnosis and prognosis of NL.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, performing a biopsy is often difficult because NL frequently shows proximal and localized involvement [5,6]. Cerebrospinal fluid cytology also plays an auxiliary role in the diagnosis of central nerve infiltration, although it is less sensitive and inadequate for detecting peripheral nerve lesions [1,7,8]. Magnetic resonance imaging (MRI) is a useful diagnostic tool for evaluating peripheral nerves in patients with NL and has been reported to have diagnostic accuracies as high as 77% [1]; however, some studies have reported accuracies as low as 40-59% [7,9], which is insufficient for a definitive diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Impact of 18F-FDG PET/CT in Predicting Recurrence in Neurolymphomatosis

Uemichi

Yokoyama

Tsuchiya

et al. 2021

Hemato

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To clarify the prognostic value of 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in Neurolymphomatosis (NL), we retrospectively reviewed medical records of all NL patients who had undergone 18F-FDG PET/CT from 2007 to 2020 at Kameda Medical Center and Tokyo Medical and Dental University Hospital. The clinical data of patients were compared with 18F-FDG PET/CT findings of number of nerve lesions and presence of non-nerve extranodal lesions (ENL). Subsequently, we calculated recurrence-free survival (RFS) and overall survival (OS) using the Kaplan–Meier method. A total of 28 patients (mean age 70.1 years, range 44–87 years; 15 women) were included in the study and 7 patients (25.0%) relapsed NL. The number of nerve lesions detected by 18F-FDG PET/CT ranged from 1 to 5, with an average of 2.02. ENL was observed in 18 cases (64.3%). The comparison between the findings revealed that the more the lesions detected by 18F-FDG PET/CT, the higher the probability of recurrence (χ2 = 13.651, p = 0.0085) and there was significantly shorter RFS for the patients with 3 or more nerve lesions (p = 0.0059), whereas the presence of ENL was not significantly associated with any clinical findings. The present study revealed that the more nerve lesions detected by 18F-FDG PET/CT, the poorer the recurrence rate and RFS.

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B-cell peripheral neurolymphomatosis: MRI and 18F-FDG PET/CT imaging characteristics

Cited by 38 publications

References 26 publications

Peripheral nerve neurolymphomatosis: Clinical features, treatment, and outcomes

Peripheral nerve neurolymphomatosis: Clinical features, treatment, and outcomes

CT Imaging Characteristics and Influence Factors of Renal Dialysis-Associated Peritoneal Injury

Impact of 18F-FDG PET/CT in Predicting Recurrence in Neurolymphomatosis

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