B cell signet-ring cell lymphoma of bone marrow.

Abstract

A case of signet-ring cell lymphoma affecting the bone marrow and diagnosed by bone marrow trephine biopsy is reported. Normal marrow was replaced totally by cells with large central vacuoles, many of which displaced the nucleus to the periphery of the cell, imparting a signet-ring appearance. Initially, the favoured morphological diagnosis was metastatic signet-ring adenocarcinoma, but on immunocytochemistry the tumour cells were strongly positive for CD45 (leucocyte common antigen) and the B cell marker CD20 (L26). Electron microscopy revealed electron-lucent vacuoles with no discernable internal structure. The tumour was classified as a high grade centroblastic lymphoma using the upgraded Kiel classification. Despite chemotherapeutic treatment, the patient died during an episode of septicaemic shock within two months of presentation.

Signet Ring Cell Lymphoma of the Small Bowel: A case report

“…4 The most common sites involved are the lymph nodes. 2 However, extra-nodal sites such as the orbit, 5 skin, 6 stomach, 7 thyroid gland, 8 salivary gland, 9 central nervous system, 10 tonsils, and the bone marrow, 11 have also been reported. Small bowel SRCL has only been reported once.…”

Case Report of Very Late Gastric Cancer Recurrence

“…Signet ring cell lymphoma can be distinguished from solidtumour malignancies by immunohistochemistry. Lymphoma cells stain strongly positive for CD45 (leukocyte common antigen) and CD20 (B-cell marker) 17 . Immunohistochemistry was used in the present case to clarify the diagnosis of recurrent gastric cancer and to exclude the possibility of an underlying lymphoma.…”

Aspiration Cytology of Signet-Ring Cell Lymphoma

“…The majority of cases are primary in the lymph nodes, although cases of signet-ring cell lymphoma of the thyroid, 1 skin, 5,7,10,13,14,45,50 tonsil, 6,51 breast, 11 bone marrow, 30,42 central nervous system, 34 stomach 16,19,33,43 urinary bladder, 38 salivary gland 41 and orbit 8 have been described. Signet-ring cell lymphoma is most often of B-cell origin, derived from follicular center cells; however, a few cases had a T-cell phenotype.…”

“…36 Although a rare entity, signetring cell lymphoma must also be considered in the differential diagnosis (Table I). Signet-ring cell lymphoma is an uncommon variant of follicular center cell lymphoma originally described by Kim et al 21 Sixty-seven cases subsequently appeared, [1][2][3][5][6][7][8][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25][26][28][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] with only 4 diagnosed cytologic...…”