2020
DOI: 10.3389/fimmu.2020.602868
|View full text |Cite
|
Sign up to set email alerts
|

B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS

Abstract: A highly recurrent somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-κB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here, we introduced an inducible leucine to proline point mutation into the mouse Myd88 locus, at the orthologous position L252P. When the mutation was introduced early during B cell development, B cells developed normally. However, IgM-expressing plasma cel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

2
5
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 9 publications
(7 citation statements)
references
References 80 publications
2
5
0
Order By: Relevance
“…( 15 ), and, being in line with those of K Schmidt et al. ( 16 ), firmly demonstrate the specific transforming effect of MYD88 activation in IgM PC differentiating B-cells.…”
Section: Discussionsupporting
confidence: 84%
See 4 more Smart Citations
“…( 15 ), and, being in line with those of K Schmidt et al. ( 16 ), firmly demonstrate the specific transforming effect of MYD88 activation in IgM PC differentiating B-cells.…”
Section: Discussionsupporting
confidence: 84%
“…This signature differentiates MYD88 L265P WM from other indolent B-cell tumors including marginal zone lymphomas. Our results contradict the conclusions of Sewastianik et al (15), and, being in line with those of K Schmidt et al (16), firmly demonstrate the specific transforming effect of MYD88 activation in IgM PC differentiating B-cells.…”
Section: Discussionsupporting
confidence: 62%
See 3 more Smart Citations