1987
DOI: 10.1073/pnas.84.17.6254
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B-cell-stimulatory factor 1 reverses Fc receptor-mediated inhibition of B-lymphocyte activation.

Abstract: Intact (IgG class) rabbit anti-immunoglobulin antibodies are not mitogenic for mouse B cells but inhibit proliferation induced by F(ab')2 anti-Fab fragment antibodies (anti-Ig). In addition, cross-linkage of Fc and surface immunoglobulin receptors on B cells by intact anti-Ig inhibits inositol phospholipid breakdown (but not Ca2+ flux) resulting from ligation of antigen receptors. This system, therefore, provides a polyclonal model for B-cell inactivation by antigen-antibody complexes. T-cell-derived B-cell-st… Show more

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Cited by 40 publications
(13 citation statements)
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“…43,44 In B cells, the negative regulatory effects of FcγRIIb can be abolished by the presence of cytokine IL-4. 45,46 Thus, FcγRIIb does not always serve as an inhibitory receptor in cell functions.…”
Section: Discussionmentioning
confidence: 99%
“…43,44 In B cells, the negative regulatory effects of FcγRIIb can be abolished by the presence of cytokine IL-4. 45,46 Thus, FcγRIIb does not always serve as an inhibitory receptor in cell functions.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, suppression can be overcome by T cell-derived lymphokines [5]. In this context, we have previously shown that interleukin 4 stimulates substantial levels of DNA synthesis in B cells cultured with intact anti-Ig antibodies [22]. The FcR-sIg complex therefore provides an intuitively attractive means of fine-tuning B cell responses to antigen: in other words, the degree of biological response of a particular clonal precursor would be ultimately determined by (infer aliu) the summation of positive signals (generated by ligation of sIg and lymphokine receptors), and negative ones, emanating from the FcR.…”
Section: Immunological Significancementioning
confidence: 98%
“…Cytokines can also reverse co-inhibition. The negative impact of Fc-signalling is prevented by IL-4 [35][36][37], which may open up new intracellular signalling pathways that are not susceptible to the inhibitory effects of Fcsignalling.…”
Section: What Are Some Examples Of Co-inhibitors?mentioning
confidence: 99%