B cells and the microbiota: a missing connection in food allergy

Campbell, Evelyn; Hesser, Lauren A.; Nagler, Cathryn R.

doi:10.1038/s41385-020-00350-x

Cited by 16 publications

(16 citation statements)

References 145 publications

(198 reference statements)

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“…and (3) IgA production, an essential component of mucosal immune defense. Bacterial-derived antigens and short-chain fatty acids directly interact with B cells to induce IgA production through G-protein coupled receptors signaling, and possibly act indirectly through intestinal epithelial cells or dendritic cells in T-cell-dependent and -independent pathways ( 99 ). However, other studies reported conflicting results.…”

Section: Probiotic Interventionmentioning

confidence: 99%

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Cao

Zheng

et al. 2022

Front. Immunol.

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Food allergies and other immune-mediated diseases have become serious health concerns amongst infants and children in developed and developing countries. The absence of available cures limits disease management to allergen avoidance and symptomatic treatments. Research has suggested that the presence of maternal food allergies may expose the offspring to genetic predisposition, making them more susceptible to allergen sensitization. The following review has focused on epidemiologic studies regarding maternal influences of proneness to develop food allergy in offspring. The search strategy was “food allergy OR maternal effects OR offspring OR prevention”. A systematically search from PubMed/MEDLINE, Science Direct and Google Scholar was conducted. Specifically, it discussed the effects of maternal immunity, microbiota, breastfeeding, genotype and allergy exposure on the development of food allergy in offspring. In addition, several commonly utilized prenatal and postpartum strategies to reduce food allergy proneness were presented, including early diagnosis of high-risk infants and various dietary interventions.

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Section: Probiotic Interventionmentioning

confidence: 99%

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Cao

Zheng

et al. 2022

Front. Immunol.

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“…Commensal microorganisms modulate B cells to produce various cytokines for maintaining homeostasis or promoting inflammation 73 . Bregs can be induced by intestinal microbiota to produce IL‐10 to combat arthritis in mice 62 .…”

Section: Microbiota and B‐cell Functionmentioning

confidence: 99%

“…Commensal microorganisms modulate B cells to produce various cytokines for maintaining homeostasis or promoting inflammation. 73 Bregs can be induced by intestinal microbiota to produce IL-10 to combat arthritis in mice. 62 Moreover, the microbial metabolite butyrate has the potential to attenuate arthritis severity by triggering Breg-producing IL-10 production while inhibiting GC and plasma cell formation.…”

Section: Cytokine Productionmentioning

confidence: 99%

Gut microbiota shape B cell in health and disease settings

Wang

Chu

2021

Journal of Leukocyte Biology

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Recent accumulating evidence supports the hypothesis that the intricate interaction between gut microbiota and the immune system profoundly affects health and disease in humans and mice. In this context, microbiota plays an important role in educating and shaping the host immune system which, in turn, regulates gut microbiota diversity and function to maintain homeostasis. Studies have demonstrated that intestinal microbiota participates in shaping B cells in health and disease settings. Herein, we review the recent progress in understanding how microbiota regulates B-cell development, focusing on early-life B-cell repertoire generation in GALT and how microbial products, including microbial antigens and metabolites, affect B-cell activation and differentiation to ultimately regulate B-cell function. We also discuss the interaction between gut microbiota and B cells under pathogenic conditions and highlight new approaches that can be applied to treat various diseases.

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“…Furthermore CD4 + Foxp3 + Treg and CD8 + Foxp3 + Treg cooperate to limit allergic symptoms via IL-10 secretion during allergen immunotherapy ( 7 ). Regulatory B cells (Breg) regulate immune responses by suppressing effector T cells through the production of anti-inflammatory cytokines (IL-10 and TGF-β) ( 8 ). In mice, IL-10-secreting Breg decrease anaphylaxis following a challenge with cow’s milk allergens through the induction of CD4 + Foxp3 + Treg ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy

et al. 2022

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Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preventive nutritional strategies with prebiotics are an attractive option, as prebiotics such as galacto-oligosaccharides and inulin can promote tolerance, epithelial barrier reinforcement, and gut microbiota modulation. Nonetheless, the ideal period for intervention remains unknown. Here, we investigated whether galacto-oligosaccharide/inulin supplementation during gestation could protect offspring from wheat allergy development in BALB/cJRj mice. We demonstrated that gestational prebiotic supplementation promoted the presence of beneficial strains in the fecal microbiota of dams during gestation and partially during mid-lactation. This specific microbiota was transferred to their offspring and maintained to adulthood. The presence of B and T regulatory immune cell subsets was also increased in the lymph nodes of offspring born from supplemented mothers, suggestive of a more tolerogenic immune environment. Indeed, antenatal prebiotic supplementation reduced the development of wheat allergy symptoms in offspring. Our study thus demonstrates that prebiotic supplementation during pregnancy induces, in the offspring, a tolerogenic environment and a microbial imprint that mitigates food allergy development.

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B cells and the microbiota: a missing connection in food allergy

Cited by 16 publications

References 145 publications

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Gut microbiota shape B cell in health and disease settings

Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy

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