2007
DOI: 10.1111/j.1365-2567.2007.02677.x
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B cells modulate T cells so as to favour T helper type 1 and CD8+ T‐cell responses in the acute phase of Trypanosoma cruzi infection

Abstract: Summary In this study, we have evaluated the production of pro‐ and anti‐inflammatory cytokines and the formation of central and effector memory T cells in mice lacking mature B cells (muMT KO). The results show that Trypanosoma cruzi infection in C57Bl/6mμ MT KO mice is intensified in relation to control mice and this exacerbation is related to low levels of inflammatory cytokines produced during the acute infection and the lower numbers of central and effector memory CD4+ and CD8+ T cells generated during th… Show more

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Cited by 55 publications
(57 citation statements)
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“…As a result of this process, regulation of the cellular response occurs due to a reduction in the activation of dendritic cells and in the macrophage's microbicidal activity. In addition, IL-4 takes part in inducing transforming growth factor (TGF)β which regulates the activity of the antigen presenting cells and enhance the susceptibility of infection by T. cruzi [32] . In this sense, we observed in our experimental model [31,33] (n = 6 for each group and each experiment performed) that vaccinated animals had a significant increase of IL-12, down regulation of the proinflammatory cytokines, IL-6, IFNγ, TNFα, and increase of soluble TNF receptors sTNFIR and sTNFIIR, which inhibit the deletereous activity of TNFα, in accord with Camargo et al [27] .…”
Section: Soluble Mediators and Cellsmentioning
confidence: 99%
See 1 more Smart Citation
“…As a result of this process, regulation of the cellular response occurs due to a reduction in the activation of dendritic cells and in the macrophage's microbicidal activity. In addition, IL-4 takes part in inducing transforming growth factor (TGF)β which regulates the activity of the antigen presenting cells and enhance the susceptibility of infection by T. cruzi [32] . In this sense, we observed in our experimental model [31,33] (n = 6 for each group and each experiment performed) that vaccinated animals had a significant increase of IL-12, down regulation of the proinflammatory cytokines, IL-6, IFNγ, TNFα, and increase of soluble TNF receptors sTNFIR and sTNFIIR, which inhibit the deletereous activity of TNFα, in accord with Camargo et al [27] .…”
Section: Soluble Mediators and Cellsmentioning
confidence: 99%
“…As it was above mentioned, both types of cells secrete IFNγ, which activates the macrophage in order to exert trypanosomicide activity by means of NO. Antigen presenting cells like macrophages, dendritic cells and B lymphocytes play an essential role in generating effector T lymphocytes, which produce different cytokines involved in the polarization of the TH1 or TH2 immune response [32] . Despite this, T. cruzi is capable of surviving in the host for long periods, which contributes to the development of symptoms and chronic disease [54] .…”
Section: Adaptive Immune Responsementioning
confidence: 99%
“…During the acute phase, an effective immune response is settled to control parasite replication in the tissues [5] . NK, T, and B cells are crucial to mediate parasite clearance through the production of interferon-γ, interleukin-17 and specific antibodies [4][5][6][7] . Immunity cannot sterilize the host, thus leading to infection persistence and therefore, a chronic disease [5] .…”
Section: Introductionmentioning
confidence: 99%
“…Outro componente importante da imunidade inata são as células Natural Killers. Além de lisarem diretamente as células infectadas, as NKs são capazes de produzir enormes quantidades de IFN-γ, principalmente no fígado de camundongos durante a fase aguda da infecção, o que é consequência da produção de IL-12 e TNF-α pelas células dendríticas e macrófagos (Golgher e Gazzinelli, 2004;Sardinha et al, 2006;Cardillo et al, 2007).…”
Section: Infecção Chagásica E Resposta Imuneunclassified