B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster

Hanlon, Stacey L; Hawley, R. Scott

doi:10.1016/j.cub.2023.04.028

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…speltoides, extensive observations suggest that the asymmetric formation of microtubules induces nondisjunction rather than a dysfunctional centromere [11,14,60]. Interestingly, a recent study of Drosophila by Hanlon and Hawley [61] showed that the female B transmission to progeny in a specific genetic background is non-drive, but in a mutant background the authors observed a biased transmission of the B chromosomes on the female side, thereby indicating a meiotic drive suppression system. Similar to the 1B × 0B cross, A. lancea 2B female plants also tended to preferentially transmit Bs to the next generation (Table 3).…”

Section: Lanceamentioning

confidence: 99%

B chromosome and its non-Mendelian inheritance inAtractylodes lancea

Hara,

Kikuchi,

Inoue

et al. 2024

Preprint

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Supernumerary B chromosomes contribute to intraspecific karyotypic variation. B chromosomes have been detected in more than 2000 organisms; they possess unique and diverse features, including non-Mendelian inheritance. Here we report one or more B chromosomes in the gynodioecious plant,Atractylodes lancea. Among 54A. lancealines, 0–2 B chromosomes were detected in both hermaphroditic and female plants, with the B chromosomes appearing as DAPI-bright regions within the nuclei. Genomicin situhybridization revealed that the B chromosomes had no conserved A chromosome DNA sequences, which was confirmed by fluorescencein situhybridization probed with independently dissected B chromosomes. In male meiosis, the B chromosome did not pair with an A chromosome and was therefore eliminated; accordingly, only 20.1% and 18.6% of these univalent B chromosomes remained at the end of meiosis for the 1B lines of KY17-148 and KY17-118, respectively. However, we also found that B chromosomes were transmitted from male parents in 40.8%–44.2% and 47.2% of the next generation; although these transmission rates from male parents were not essentially different from Mendelian inheritance (0.5), the transmission of gametes carrying B chromosomes increased through fertilization or seed development. B chromosomes were transmitted from three of four 1B female parents to 64.3%–92.6% of the next generation, suggesting B chromosome accumulation. We propose that the B chromosome ofA. lanceahas a specific sequence and persists via non-Mendelian inheritance from female parents. Overall,A. lanceais a useful material for understanding the structure, evolution, and mechanism of non-Mendelian inheritance of B chromosomes.

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Section: Lanceamentioning

confidence: 99%

B chromosome and its non-Mendelian inheritance inAtractylodes lancea

Hara,

Kikuchi,

Inoue

et al. 2024

Preprint

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“…8 Female meiotic drive is thought to be accomplished through preferential segregation to the egg, exploiting the inherent asymmetry in female meiosis: only the chromosomes that segregate to the egg will transmit. 3,9–11 In contrast, male meiosis undergoes symmetric divisions, and cheating mostly happens post-meiosis. 5,7,8 Male (and spore killer) meiotic drivers typically act through the sabotage or death of competitor sperm/spores that do not carry them.…”

Section: Introductionmentioning

confidence: 99%

An egg sabotaging mechanism drives non-Mendelian transmission in mice

Clark,

Greenberg,

Silva

et al. 2024

Preprint

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SummaryDuring meiosis, homologous chromosomes segregate so that alleles are transmitted equally to haploid gametes, following Mendel’s Law of Segregation. However, some selfish genetic elements drive in meiosis to distort the transmission ratio and increase their representation in gametes. The established paradigms for drive are fundamentally different for female vs male meiosis. In male meiosis, selfish elements typically kill gametes that do not contain them. In female meiosis, killing is predetermined, and selfish elements bias their segregation to the single surviving gamete (i.e., the egg in animal meiosis). Here we show that a selfish element on mouse chromosome 2,R2d2, drives using a hybrid mechanism in female meiosis, incorporating elements of both male and female drivers. IfR2d2is destined for the polar body, it manipulates segregation to sabotage the egg by causing aneuploidy that is subsequently lethal in the embryo, so that surviving progeny preferentially containR2d2. In heterozygous females,R2d2orients randomly on the metaphase spindle but lags during anaphase and preferentially remains in the egg, regardless of its initial orientation. Thus, the egg genotype is either euploid withR2d2or aneuploid with both homologs of chromosome 2, with only the former generating viable embryos. Consistent with this model,R2d2heterozygous females produce eggs with increased aneuploidy for chromosome 2, increased embryonic lethality, and increased transmission ofR2d2. In contrast to a male meiotic driver, which kills its sister gametes produced as daughter cells in the same meiosis,R2d2eliminates “cousins” produced from meioses in which it should have been excluded from the egg.

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Cell biology: Selfish B chromosomes unleashed by a dysfunctional chromosome segregation system

Ferree

2023

Current Biology

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B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster

Cited by 5 publications

References 55 publications

B chromosome and its non-Mendelian inheritance inAtractylodes lancea

B chromosome and its non-Mendelian inheritance inAtractylodes lancea

An egg sabotaging mechanism drives non-Mendelian transmission in mice

Cell biology: Selfish B chromosomes unleashed by a dysfunctional chromosome segregation system

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