<b>Decreased nocturnal melatonin secretion in patients with Klinefelter's syndrome</b>

Luboshitzky, Rafael; Wagner, Oded; Lavi, Schachar; Herer, Paula; Lavie, Peretz

doi:10.1046/j.1365-2265.1996.8710881.x

Cited by 16 publications

(6 citation statements)

References 22 publications

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“…Recently, we have demonstrated that GnRH deficient males have increased nocturnal melatonin secretion (Luboshitzky et al, 1995a) while hypergonadothrophic hypogonadal patients have decreased melatonin concentrations (Luboshitzky et al, 1996b).…”

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confidence: 99%

Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment

Luboshitzky

Wagner

Lavi

et al. 1997

Clinical Endocrinology

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mentioning

confidence: 99%

Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment

Luboshitzky

Wagner

Lavi

et al. 1997

Clinical Endocrinology

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“…[1][2][3] Animal models of PD as well as several publications regarding circulating levels of melatonin in Klinefelter's syndrome provide evidence that melatonin may play a role in neuroprotection. Luboshitzky et al 4 reported low levels of nocturnal melatonin release and low testosterone levels in a subgroup of patients with Klinefelter's syndrome. In both the control group and the group of patients with Klinefelter's syndrome but normal testosterone concentrations, the patients maintained similar melatonin concentrations.…”

Section: Parkinson's Syndrome In a Young Patient With Klinefelter's Smentioning

confidence: 99%

Parkinson's syndrome in a young patient with Klinefelter's syndrome —A case report

et al. 2008

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the sister (V: 11) with ataxia and retinitis pigmentosa now has mild Parkinsonism.Homozygous SCA2 patients develop levodopa responsive Parkinsonism with dyskinesia and motor fluctuations suggesting a pre-synaptic lesion and eventually progress to develop dementia with psychosis and ataxia. Probands with homozygous SCA2 mutations do not have slow eye movements at onset but these appear later in the disease. Followup of this family with homozygous SCA2 mutations shows that homozygous mutations have different phenotypic presentations than the heterozygotes, a more severe phenotype and rapid progression, possibly, due to the additional load of mutant protein. This is similar to Huntington's disease caused by homozygous mutation that presents with Parkinsonism and ataxia and the disease progresses rapidly. 2

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“…A large body of information suggests that melatonin and the reproductive hormones are interrelated. This concept is based on observations of increased melatonin levels in hypogonadal patients with gonadotropin-releasing hormone (GnRH) deficiency [1][2][3][4] , and decreased melatonin concentrations in individuals with precocious puberty 5 or primary hypogonadism 6 . Testosterone or estradiol (E 2 ) replacement therapy administered to hypogonadal patients normalized their melatonin levels 2,3 .…”

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confidence: 99%

Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women with polycystic ovary syndrome: the effect of ethinyl estradiol–cyproterone acetate treatment

Luboshitzky

Shen‐Orr

Herer

et al. 2003

Gynecological Endocrinology

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The role of melatonin in human reproduction is still unknown. Data obtained in patients with hypogonadism and precocious puberty suggest that melatonin and the reproductive hormones are interrelated. The aim of this study was to determine melatonin production in hyperandrogenic women. We studied 12 women with polycystic ovary syndrome (PCOS) and 10 women with idiopathic hirsutism (IH). Patients were treated with cyproterone acetate-ethinyl estradiol (Diane 35) for 4 months. Fasting blood samples for the determination of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone and dehydroepiandrosterone sulfate (DHEAS) and 24-h urine collections for the determination of 6-sulfatoxymelatonin (alpha MT6s) excretion were obtained from all patients at baseline and after 4 months of treatment. The results were compared with those obtained in 15 control women. At baseline, women with PCOS had significantly higher LH and testosterone levels than those with IH and controls. Their alpha MT6s values (52.6 +/- 20.3 micrograms/24 h) were significantly higher than the values in women with IH (34.3 +/- 7.1) and controls (30.5 +/- 6.5) (p < 0.001). Diane 35 treatment significantly decreased LH, FSH, testosterone and alpha MT6a values in PCOS (28.0 +/- 13.9 micrograms/24 h) (p < 0.0001). These results indicate that women with PCOS have increased melatonin production. The normalization of alpha MT6s and testosterone values during Diane 35 treatment suggests that sex steroids modulate melatonin secretion in these patients either directly or through the suppression of gonadotropin.

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Decreased nocturnal melatonin secretion in patients with Klinefelter's syndrome

Cited by 16 publications

References 22 publications

Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment

Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment

Parkinson's syndrome in a young patient with Klinefelter's syndrome —A case report

Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women with polycystic ovary syndrome: the effect of ethinyl estradiol–cyproterone acetate treatment

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