This paper focuses on the synchronization of uncertain coronary artery chaos systems (CACSs) with the state and input time-varying delays under input saturation. First, the stability of the closed-loop system is established to ensure the synchronization between the diseased and healthy CACSs under input saturation by utilizing the local sector condition and the Lyapunov-Krasovskii functional (LKF) method. The use of Wirtinger inequality and the reciprocally convex method further reduces the conservatism. Second, by making use of the cone complementary linearization approach to deal with nonlinear terms, we obtained a state feedback controller. Finally, a robust state feedback controller is formulated to achieve the synchronization of the CACS under disturbances bounded by L 2 norm. The simulation results of the CACS synchronization are presented to demonstrate the effectiveness of the derived results, which provides a certain theoretical basis for curing diseases related to the coronary artery vessel.