Retracted: C/EBPβ Promotion of MMP3-Dependent Tumor Cell Invasion and Association with Metastasis in Colorectal Cancer

Ji, Yuanyuan; Li, Junkuo; Pan, Li; Wang, Li; Yang, Haijun; Jiang, Guozhong

doi:10.1089/gtmb.2017.0113

Cited by 20 publications

(11 citation statements)

References 38 publications

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“…MMP3 can degrade different collagens (such as types II, III, IV, IX, and X), proteoglycans, fibronectin, laminin, and elastin but can also activate MMP1, 7, and 9, proteins which play a crucial role in connective tissue remodeling [52,53]. Alterations in MMP3 expression and function are also involved in tumor metastasis [47,54,55]. In the current study, our bioinformatic analysis and luciferase reporter assay revealed that miR-134 was able to bind to the 3 0 -UTR of MMP1 and MMP3 and inhibited MMP1 and MMP3 translation or reduce MMP1/MMP3 message levels in osteosarcoma cells, which was correlated with the overexpression of miR-134 and inhibition of osteosarcoma cell migration, invasion, and metastasis in vitro and in nude mice.…”

Section: Discussionmentioning

confidence: 99%

miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo

et al. 2019

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miR‐134 has been shown to be associated with angiogenesis and the progression of osteosarcoma. This study further assessed the effects of miR‐134 expression on osteosarcoma cell migration, invasion, and metastasis in vitro and in a nude mouse xenograft model, exploring the underlying molecular events. Luciferase reporter assays revealed that miR‐134 directly targets the 3′‐UTRs of MMP1 and MMP3 to reduce their expression in osteosarcoma cells. In conclusion, overexpression of miR‐134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. We propose miR‐134 as an attractive novel therapeutic target for the treatment of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo

et al. 2019

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“…promoted the growth and metastasis of esophageal squamous cell carcinoma (42). It has also been identified that MMP1 participated in breast and ovarian cancer (43,44 (46). PLOD2 has been shown to play a role in cervical cancer (35) and renal cell carcinoma (47).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of two novel genes SNX10 and PTGDS for cervical squamous cell carcinoma: an integrated bioinformatic analysis

Jiang¹,

Cao²,

Gao³

et al. 2020

Preprint

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KEYWORDSCervical squamous cell carcinoma, methylation prognosis risk model SNX10, PTGDS in females (1). Despite pre-cancerous screening and emerging treatments, CC remains the primary cause of death in women in developing countries (2). When CC becomes metastasizes and recurs, the prognosis gets even worse. Therefore, it is of great significance to establish target treatments of CC based on its to-be-clarified molecular mechanism.Gene expression microarray, as an efficient means of acquiring large-scale genetic data, has been mostly used to study gene expression profiling in many human cancers. New methods and good foreground are provided by microarrays for studying tumor-associated genes, molecular targeting, molecular prediction and therapy. The integration of databases containing gene expression chips allows in-depth study of molecular mechanisms(3, 4).Up to now, the expression profiles of thousands of differentially expressed genes (DEGs) in CC have been researched (5-7). However, the results on some mRNAs are inconsistent. Here we use an unbiased approach to solve this problem.In our study, we screened DEGs from four profiles downloaded from GEO. PPI network was built by STRING Database and hub modules selected via plug-in MCODE. CMap was used to find potential molecules associated with CC. We also validated hub genes with GEO datasets, GEPIA, immunohistochemistry and ONCOMINE. ROC curve analysis and GESA were also done to tease out the significance of hub genes. The flow chart of this research was displayed in Fig. 1. Methods Screening DEGsKeywords "cervical cancer geo accession" were put in the GEO database (https://www.ncbi.nlm.nih.gov/geo/) and the gene expression profiles of GSE6791, GSE63514, GSE39001 and GSE9750 were downloaded. The dataset information is shown in Table 1. We processed unqualified data by R package. The data is calibrated, standardized and log2-transformed.Gene expression analysis was performed using the limma(8) package in the Bioconductor package.Relevant codes were placed into R. We selected four microarray datasets and analyzed them with limma. The |log2fold change (FC)| > 2 and adjusted p < 0.05 were set as cutoffs. RRA package was download (http://cran.r-project.org/)(9) and R was used for running the instruction code.

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“…In prostate cancer cells, PI3K/ AKT and ERK1/2 pathways were enhanced by the activation of P2X7R after ATP addition, with the downriver invasiveness-associated genes Claudin-1, E-cadherin, interleukin-8, and matrix metalloproteinase-3 (MMP-3) which is attend as further inductors [28]. In addition, MMP-3-dependent tumor cell invasion was also showed in mouse-CRC [29]. These data implied that an overexpression of P2X7R may also induce MMP-3-dependent tumor cell invasion in cancer.…”

Section: Discussionmentioning

confidence: 99%

P2X7R as an independent prognostic indicator in gastric cancer

Çalık

Sarikaya

et al. 2020

Bosn J of Basic Med Sci

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Gastric cancer is one of the foremost causes of cancer related death around the world. The P2X7 receptor (P2X7R), a member of the P2X receptor subfamily of P2 receptors, is a unique molecule that has been shown to affect tumor growth and progression as well as various inflammatory processes, including proliferation of T lymphocytes, release of cytokines, and production of free oxygen radicals. P2X7R has been established as a prognostic parameter in some cancers and, recently, it has been investigated in the development of new targeted therapies. In the present study, we aimed to investigate the prognostic value of P2X7R expression in GC. The expression profile of P2X7R was evaluated immunohistochemically in 156 paraffin-embedded human gastric cancer specimens. P2X7R expression was higher in patients with lymph node metastasis than in those without (p < 0.001). P2X7R overexpression was closely related with tumor-infiltrating lymphocytes [TILs] (p = 0.001), vascular invasion (p = 0.006), depth of invasion (p < 0.001), distant metastasis (p < 0.001), and advanced TNM stage (p < 0.001). Moreover, univariate (HR 3.98; 95% CI 1.89–11.82; p < 0.001) and multivariate (HR 2.24; 95% CI 3.53–12.50; p < 0.001) Cox regression analysis showed that upregulated P2X7R expression clearly correlated with worsened overall survival. In summary, our data revealed that P2X7R may serve as a reliable prognostic parameter and promising therapeutic target for gastric cancer.

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Retracted: C/EBPβ Promotion of MMP3-Dependent Tumor Cell Invasion and Association with Metastasis in Colorectal Cancer

Abstract: C/EBPβ upregulation promoted tumor cell invasion in an MMP3-dependent manner in vitro and was associated with metastatic status in CRC.

Cited by 20 publications

References 38 publications

miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo

miR‐134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo

Prognostic value of two novel genes SNX10 and PTGDS for cervical squamous cell carcinoma: an integrated bioinformatic analysis

P2X7R as an independent prognostic indicator in gastric cancer

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