Long-term stability of cefuroxime and cefazolin sodium in intravenous infusions

Abstract

Cefazolin and cefuroxime sodium are often used as antibiotic infusions for hospitalized patients. Because advance preparation of these intravenous solutions is efficient, the stability of both antibiotics stored at 4 degrees C in polyvinyl chloride (PVC) bags was studied. Five bags of solutions containing either 1 g of cefazolin sodium or 1.5 g of cefuroxime sodium per 100 ml of 5% dextrose were studied for 1 month by high-performance liquid chromatography (HPLC), visual inspection and pH measurement. No colour change or precipitation was observed. The pH values of both drugs increased significantly over the period of study. Based on a shelf-life of 90% residual potency, the cefuroxime sodium concentration was stable for 13 days when stored at 4 degrees C, and the cefazolin sodium concentration was stable for at least 30 days at 4 degrees C. Within these limits, both antibiotics may be prepared in advance by a centralized intravenous admixture service.

Stability of Commonly Used Antibiotic Solutions in an Elastomeric Infusion Device

“…Previously published studies for cefazolin, [15][16][17][18][19][20][21] ceftazidime, 7,18,20,22 ceftriaxone, 6,18,20,[23][24][25][26] clindamycin, 17,21,[26][27][28] and vancomycin 8,[29][30][31] all reported stability data and expiration dates that were in general agreement with the results reported here. In some cases, the recommended expiry dates in those previously studies were longer than those determined in the current study, largely because the beyond-use dates calculated here were based on 95% CIs, whereas 95% CIs were not calculated in most of the earlier studies.…”

“…[6][7][8][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30] Previously published studies often used only linear regression to calculate the percent remaining on the last study day. The time to reach 90% of the initial concentration (T-90%) can be calculated on the basis of the observed concentration remaining as reported in previous publications [6][7][8][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and compared to the T-90% determined for each drug in the current study (Table 7, Figure 1). Calculation of T-90% yields a better overall estimate of expiry date because it minimizes the effect of study duration and day-to-day variability in the estimates of concentration.…”

Long-term stability of vancomycin hydrochloride in intravenous infusions

“…It is usually given as an admixture in 5% dextrose or 0.9% sodium chloride injection solutions (2). Advance batch preparation of intravenous solutions is efficient and is Correspondence: Dr L. M. Galanti, Laboratory, University Hospital of Mont-Godinne, Belgium. increasingly being used by hospital pharmacists in several countries (3)(4)(5)(6)(7)(8)(9). Centralized preparation of antibiotics requires that their stability is known (10).…”

Therapeutic use of cephazolin to prevent complications of spine surgery

“…Therefore, the entry and effectiveness of some antibiotics will be infl uenced because of mutually repellant charges between the antibiotic and the proteoglycans (Currier et al, 1994;Eismont et al, 1987;Gibson et al, 1987;Thomas et al, 1995). While there are many methods for detecting cephazolin in serum and vascular organs (Beovic et al, 1999;Galanti et al, 1996;Gupta and Stewart, 1980;How et al, 1998;Hume et al, 1983;Lanao et al, 1988;Liang et al, 1994;Low et al, 2000;Polk et al;, Walker et al, 1986Watanabe et al, 1980;Wold and Turnipseed, 1977) few methods are applicable to the avascular intervertebral disc (Boscardin et al, 1992;Riley, 1998;Fraser et al, 1989). Despite the wide array of techniques for the quantifi cation of cephazolin, the current literature lacks publications relating to high-performance liquid chromatography (HPLC) methods for detecting and measuring the concentration of cephazolin in plasma and the intervertebral disc.…”