<b>Low Vitamin D Levels: Are Associated with Both Iron Deficiency and Anemia in Children and Adolescents?</b>

Kartal, Özgür; Kartal, Ayşe Tuğba

doi:10.3109/08880018.2015.1022916

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…However, there are also studies showing no association with the prevalence of vitamin D in children with iron deficiency anemia. 19 In our study, no correlation was found regarding the prevalence of vitamin D in children with iron deficiency. Further studies are needed for the association between VDD and anemia.…”

Section: Resultscontrasting

confidence: 64%

Is There a Relationship Between Vitamin D Level and Iron Deficiency Anemia in Children?

Kaçer

Kılıçaslan

2023

JPA

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Iron deficiency anemia (IDA) is the most common type of anemia in children and a major cause of morbidity and mortality. VitaminD deficiency (VDD) is a growing public health issue that has been connected to several chronic diseases, such as osteoporosis,cancer, and metabolic syndrome. Recently, in a meta-analytic study conducted on both children and adults, it was clearly shownthat there is a relationship between VDD and the risk of anemia. In this study, we wanted to review the prevalence of vitamin Dinsufficiency in children with IDA. We conducted a retrospective review of patient records from January 2017 to December 2019 toidentify individuals aged 4 months to 18 years who had been diagnosed with IDA. Demographic data, dietary patterns, nutritionalsupplements, Vitamin D levels, and laboratory tests were recorded. Two hundred thirty girls and 198 boys were enrolled in thestudy, bringing the total number of patients to 428. The patients had a mean age of 7.24±5.1 months. The distribution of femalegender according to vitamin D groups (normal, insufficient, deficient) was 85, 103, and 42, respectively; the male gender is 78,89, and 31, respectively (p=0.745). No statistically significant difference was found between nutrition categories and vitamin Dgroups in different age groups (p=0.293; p=0.238; p=0.396). No statistically significant difference was found between continuousquantitative variables such as age, hemoglobin, and ferritin and vitamin D groups in different age groups (p=0.885; p=0.168;p=0.728). There was no significant association observed between the severity of anemia and VDD in children with IDA in our study.In the diagnosis of IDA, it may be useful to look at vitamin D levels by considering the time of admission. Further studies are neededfor the association between vitamin D levels and IDA.

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Section: Resultscontrasting

confidence: 64%

Is There a Relationship Between Vitamin D Level and Iron Deficiency Anemia in Children?

Kaçer

Kılıçaslan

2023

JPA

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“…11 Zilli and colleagues reported that vit D deficiency is common in individuals with atrophic gastritis and a similar etiopathogenesis causes vit B12 deficiency. 12 While iron deficiency was detected in 11.8% of the cases, the prevalence of B12 deficiency was 23.4%, suggesting the presence of an absorption problem rather than a nutritional deficiency. The fact that vit D deficiency, whose immunological functions are well known, was as high as 49% in our study and that it was found to be associated with vit B12 deficiency suggests that this situation may be of autoimmune origin.…”

Section: Discussionmentioning

confidence: 91%

“…Aktaş from our country reported that there is a negative correlation between vit B12 and vit D levels in patients with autoimmune hypothyroidism 11. Zilli and colleagues reported that vit D deficiency is common in individuals with atrophic gastritis and a similar etiopathogenesis causes vit B12 deficiency 12. While iron deficiency was detected in 11.8% of the cases, the prevalence of B12 deficiency was 23.4%, suggesting the presence of an absorption problem rather than a nutritional deficiency.…”

Section: Discussionmentioning

confidence: 97%

“…9,10 Although there are publications showing a relationship between iron deficiency and vitamin D (vit D), there are very few studies showing a relationship between vit D deficiency and vit B12 deficiency. [11][12][13][14] As far as we know, there is no study investigating the relationship between vit B12 deficiency and vit D in healthy children. In our study, an association between vit B12 levels and vit D was investigated in healthy school-age children.…”

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confidence: 99%

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Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?

Karabayır¹,

Teber

Dursun

et al. 2021

Journal of Pediatric Hematology/Oncology

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Vitamin B12 (vit B12) or cobalamin is a water-soluble vitamin that acts as a coenzyme and is effective in the formation of a healthy nervous system and erythrocytes. In its deficiency, except fatigue and weakness, may cause serious signs and symptoms such as macrocytic anemia, cognitive-developmental delay, irreversible neurological damage. In this study, hemoglobin, leukocyte, thrombocyte, iron, ironbinding, ferritin, and vit B12 levels were evaluated retrospectively during the routine controls of 689 children 5 to 18 years old without any complaints. In addition, the relationship between serum 25-Hydroxyvitamin D (vit D) levels and vit B12 levels, which were evaluated in 487 of the cases, was investigated. Vit B12 deficiency was diagnosed in a total of 160 (23.2%) cases, 99 (24.4%) girls and 61 (21.4%) boys. Vit B12 level was significantly lower in children over 12 years old. Vitamin D deficiency was found to be 49.3% in 487 cases and was significantly higher in the group under 12 years and girls. The frequency of anemia was 7.2% in this group. There was a significant relationship between vit D deficiency and vit B12 deficiency. In conclusion, vit B12 deficiency is common in school-age children, especially in the adolescent age group. It should be known that vit D deficiency may also be present in vit B12 deficiency cases. More comprehensive studies are needed to reveal the relationship between B12 and vit D deficiency.

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Low Vitamin D Levels: Are Associated with Both Iron Deficiency and Anemia in Children and Adolescents?

Cited by 2 publications

References 6 publications

Is There a Relationship Between Vitamin D Level and Iron Deficiency Anemia in Children?

Is There a Relationship Between Vitamin D Level and Iron Deficiency Anemia in Children?

Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?

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