B-Lymphocyte Alloantigens Associated with Systemic Lupus Erythematosus

Reinertsen, James L.; Klippel, John H.; Johnson, Armead H.; Steinberg, Alfred D.; Decker, John L.; Mann, Dean L.

doi:10.1056/nejm197809072991004

Cited by 275 publications

(77 citation statements)

References 23 publications

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“…The association between susceptibility to SLE and DRw2 and DRw3 has also been recognized in another population by Reinartsen et al . (10) as well as in a preliminary report on the present patients (11) . Serum 1283 and the related sera 259 and 1038 detected an alloantigen shared by individuals positive for either DRw4, DRw7, or DRw10 .…”

Section: Discussionsupporting

confidence: 68%

Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus.

Gibofsky¹,

Winchester²,

Patarroyo³

et al. 1978

The Journal of Experimental Medicine

185

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Increasing evidence has been obtained of the special value of Ia-like B-cell alloantisera for demonstrating disease associations with histocompatibility antigens. This was particularly evident for the study of the immunogenetics of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), two conditions frequently considered related. The profiles of antigens recognized by the alloantisera in patients from each disease group was distinctive. Two types of alloantisera were obtained that illustrated the divergence between the twod iseases. One type showed a higher than normal incidence in RA but lower than normal in SLE; the other showed a higher incidence in SLE. While these sera were not totally defined, evidence was obtained that the SLE-reactive alloantiserum related to two alleles of the major histocompatibility complex DRw2 and DRw3, while the RA-reactive alloantiserum related to a common specificity shared by cells positive for either DRw4, DRw7, or DRw10. The data indicate that immunogenetic factors are relevant to the development of both RA and SLE, but that these are distinct for each disease.

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Section: Discussionsupporting

confidence: 68%

Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus.

Gibofsky¹,

Winchester²,

Patarroyo³

et al. 1978

The Journal of Experimental Medicine

185

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“…Interestingly, these same HLA-DR2 haplotypes have been associated with predisposition to SLE itself in several studies of American and Western European whites (28)(29)(30)(31)(32), blacks (27,33), Chinese (34), Koreans (39, and Japanese (36), but not in Mexican-Americans (37), Greeks (17), or Bulgarians (18). In fact, the HLA-DRB1*1501 haplotype is common in whites of Western European descent, and HLA-DRB1*1503 predominates in blacks (27), while both are less frequent in Mexican-Americans (37), Chinese (34), Koreans (35), and Japanese (36), and even rare in Eastern Europeans, whereas other HLA-DR2 haplotypes occur in higher frequencies and are typically in linkage disequilibrium with HLA-DQ5 alleles (17,18).…”

Section: Discussionmentioning

confidence: 91%

Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Arnett

Reveille

Moutsopoulos

et al. 1996

Arthritis & Rheumatism

142

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Objective. To determine the frequencies and clinical associations of antiribosomal P antibodies (anti-P) in a large multiethnic cohort of patients with systemic lupus erythematosus (SLE), and to assess whether anti-P was associated with any major histocompatibility complex (MHC) class I1 alleles or shared amino acid sequences.Methods. Sera from 394 SLE patients were studied for anti-P using an enzyme-linked immunosorbent assay, and MHC class I1 alleles (HLA-DRB1, DQA1, and DQBl) were determined by DNA oligotyping.Results. Anti-P antibodies were found in 13-2W of patients in the majority of ethnic groups, but were perhaps more frequent in Chinese patients (36%) and less common in Bulgarian patients (6%). Neuropsychiatric lupus (psychosis and/or depression) was significantly associated with anti-P. The HLA-DR2, DQ6 haplotypes DRB1*1501 or *1503, DQA1*0102, and DQB1*0602 were increased in anti-P-positive whites, blacks, and Mexican Americans. The HLA-DQB1*0602 allele showed the strongest association with anti-P when these 3 ethnic groups were combined and compared with both race-matched anti-P-negative SLE patients and normal controls. The HLA-DQS specificity (DQB1*0302) was increased both in whites and in Mexican-Americans with anti-P who were negative for HLA-DQB1*0602, and perhaps also increased in Greeks, but not in blacks, in whom HLA-DQB1*0301 was increased. A shared amino acid sequence in HLADQBl (at position 26 of leucine and position 30 of tyrosine) was strongly associated with anti-P positivity (70%) versus anti-P negativity (42%) across ethnic lines.Conclusion. The anti-P response in SLE patients, occurring in -15% of patients, was strongly influenced by certain MHC class I1 alleles and was correlated with diffuse neuropsychiatric dysfunction.

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“…Since then, HLA studies have been performed on multiple SLE populations of African, Asian, European, and North, Central and South American descent demonstrating different HLA associations among the various ethnic groups. [39][40][41][42][43][44][45][46][47][48][49][50][51] From these studies, HLA-DR2 and -DR3 appear to have the strongest associations with SLE. (HLA-B8 was most consistently associated with SLE, but was later found to be in linkage disequilibrium with -DQ2 and -DR3.)…”

Section: Hla Antigensmentioning

confidence: 99%