B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

Murphy, Tanya K.; Goodman, Wayne K.; Fudge, Marilyn W.; Williams, Ralph C.; Ayoub, Elía M.; Dalal, Mayank; Lewis, Mark H.; Zabriskie, John B.

doi:10.1176/ajp.154.3.402

Cited by 161 publications

(12 citation statements)

References 31 publications

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“…Consequently, some authors tried determining whether the monoclonal antibody D8/D17 could also be used as an OCD marker. The D8/D17 mean value was shown to be higher in OCD or Tourette’s child populations vs. control subjects [80], and, as no difference was found between Tourette syndrome and OCD patients in D8/D17 values, it was hypothesized that it could be a marker for OCD in children [80]. Although these results were replicated [74,77], there is still debate surrounding this topic [71,73,81,84] (Table 2).…”

Section: Immunological Changes In Ocdmentioning

confidence: 99%

Individualized Immunological Data for Precise Classification of OCD Patients

et al. 2018

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Obsessive–compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

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Section: Immunological Changes In Ocdmentioning

confidence: 99%

Individualized Immunological Data for Precise Classification of OCD Patients

et al. 2018

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“…PANDAS tanılı 27, Sydenham koreli 9 hasta ile 24 kişilik sağlıklı kontrol grubunun dâhil edildiği bir çalışmada, D8/17 pozitiflik oranı PANDAS, Sydenham koresi ve kontrol gruplarında sırasıyla %85, %89 ve %17 olarak bulunmuştur (17) . Çocukluk çağı başlangıçlı OKB ve/veya Tourette sendromu (bir çeşit tik bozukluğu) bulunan 31 hasta ile 21 kişilik kontrol grubunun dâhil edildiği bir başka çalışmada; hastalardaki D8/17 pozitifliği oranının kontrol grubuna göre anlamlı derecede yüksek olduğu belirtilmiştir (18) . Yapılan bazı çalışmalarda ise D8/17 belirteci pozitifliği ile OKB ve tik bozukluğu arasında bir ilişki bulunmamıştır (19,20) .…”

Section: Hastalığın Immünolojik Boyutuunclassified

PANDAS Hypothesis

MİRZA¹

2016

TMCD

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Derleme ÖZET İlk kez Swedo ve arkadaşları tarafından 1998 yılında tanımlanan "streptokok ile ilişkili pediatrik otoimmün nöropsikiyatrik bozukluklar (PANDAS)" terimi, otoimmün temeli olduğu ve Anahtar kelimeler: Streptokok, tik bozukluğu, PANDAS SUMMARY PANDAS HypothesisThe term "pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)" which was first defined by Swedo et al. in 1998, has

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“…The reported prevalence of ASO antibodies ranges from 29-69% in TS to 18-52% in healthy controls (Cardona and Orefici, 2001; Kiessling et al, 1993, 1994; Müller et al, 2000; Singer et al, 1998; Murphy et al, 1997; Morshed et al, 2001; Church et al 2003; Rizzo et al, 2006). The prevalence of antibodies to DNase B ranges from 13-85% and from 8-59% for TS and controls, respectively (Kiessling et al, 1994, Müller et al, 2000; Singer et al, 1998; Murphy et al, 1997, Morshed et al, 2001). One large, long term, population-based follow up study of children after GAS infection found a strong relationship with behavior and non tic-like motor changes but no association specifically with tics (Murphy et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Immune-mediated animal models of Tourette syndrome

Hornig

Lipkin

2013

Neuroscience & Biobehavioral Reviews

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An autoimmune diathesis has been proposed in Tourette syndrome (TS) and related neuropsychiatric disorders such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism and anorexia nervosa. Environmental triggers including infection and xenobiotics are hypothesized to lead to the production of brain-directed autoantibodies in a subset of genetically susceptible individuals. Although much work has focused on Group A Streptococcus (GAS), the role of this common childhood infection remains controversial. Animal model studies based on immune and autoantibody findings in TS have demonstrated immunoglobulin (Ig) deposits and stereotypic movements and related behavioral disturbances reminiscent of TS following exposure to GAS and other activators of host anti-microbial responses, soluble immune mediators and anti-GAS or anti-neuronal antibodies. Demonstration of the ability to recreate these abnormalities through passive transfer of serum IgG from GAS-immunized mice into naïve mice and abrogation of this activity through depletion of IgG has provided compelling evidence in support of the autoimmune hypothesis. Immunologically-based animal models of TS are a potent tool for dissecting the pathogenesis of this serious neuropsychiatric syndrome.

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B lymphocyte antigen D8/17: a peripheral marker for childhood-onset obsessive-compulsive disorder and Tourette's syndrome?

Abstract: 1997; 154:402-407)

Cited by 161 publications

References 31 publications

Individualized Immunological Data for Precise Classification of OCD Patients

Individualized Immunological Data for Precise Classification of OCD Patients

PANDAS Hypothesis

Immune-mediated animal models of Tourette syndrome

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