<b>Noninvasive Diagnosis of Incomplete Endovascular Aneurysm Repair</b>: D-Dimer Assay to Detect Type I Endoleaks and Nonshrinking Aneurysms

Serino, F.; Abeni, Damiano; Galvagni, Elisabetta; Sardella, Savino G.; Scuro, Alberto; Ferrari, Mauro; Ciarafoni, Iole; Silvestri, Lorena; Fusco, Angelo

doi:10.1177/152660280200900115

Cited by 21 publications

(19 citation statements)

References 26 publications

(31 reference statements)

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“…Eleven studies reported on concentrations of plasma D-dimer 18,19,[23][24][25][26][27][28][34][35][36] the largest of which contained 1260 23 patients, whereas the smallest contained 28. 36 Recruitment was similar between studies, all recruiting from a hospital-based setting except for one, which also recruited from a population setting. 23 Methods varied between studies, although in general, USS-detected AAA patients were compared against age-matched healthy control subjects.…”

Section: Studies Comparing Patients With and Those Without Aaasmentioning

confidence: 99%

“…NS, Not specified. 2003 AAA <.0001 Nomura 24 2003 AAA .0001 Jelenska 26 2004 AAA <.001 Lee 27 1996 AAA <.001 Parry 28 2009 AAA <.001 Yamazumi 18 1998 AAA <.01 Wallinder 19 2009 AAA .001 Golledge 23 2009 AAA <.001 Serino 36 2002 AAA <.05 Aramoto 35 1994 NS NS NS, Not specified. 24 2003 AAA .0001 Parry 28 2009 AAA <.001 Yamazumi 18 1998 AAA <.01 Wallinder 19 2009 AAA <.001 Abdelhamid 32 2013 NS NS Aramoto 35 1994 AAA NS Holmberg 33 1999 AAA .001…”

Section: Supplementarymentioning

confidence: 99%

See 1 more Smart Citation

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size

Sidloff

Stather

Choke

et al. 2014

Journal of Vascular Surgery

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This study suggests that the presence of AAAs is associated with increased fibrin turnover, fibrinolysis, and thrombin generation, as shown by increased levels of fibrinogen, D-dimer, and thrombin-antithrombin III complex. This is clinically relevant because markers of hemostasis are independent risk factors for cardiovascular events, highlighting the necessity of addressing all modifiable cardiovascular risk factors in patients with AAAs. Furthermore, the finding that plasma D-dimer concentration appears to have a linear relationship with aneurysm diameter may be useful as a future biomarker of AAAs.

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Section: Studies Comparing Patients With and Those Without Aaasmentioning

confidence: 99%

Section: Supplementarymentioning

confidence: 99%

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size

Sidloff

Stather

Choke

et al. 2014

Journal of Vascular Surgery

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show abstract

“…Based on this hypothesis, raised plasma concentrations of a variety of proteins including fibrinogen, von Willebrand factor antigen, D-dimer, thrombin-antithrombin III complex and α2 -plasmin inhibitor-plasmin complex have been demonstrated in AAA patients, suggesting that coagulation pathways are activated during the course of disease 157–159. However, the publication of conflicting data implies that measurement of thrombus-associated may not be sufficiently specific to distinguish stable AAAs from age-matched controls 160. Despite this, elevated concentrations of thrombotic proteins have been demonstrated in cases of large,161 and ruptured AAA when compared to small non-ruptured aneurysms suggesting that thrombus-associated markers may have prognostic potential 162.…”

Section: 0 Future Prospects Of Aaa Diagnosis and Monitoringmentioning

confidence: 99%

Diagnosis and Monitoring of Abdominal Aortic Aneurysm: Current Status and Future Prospects

Moxon

Parr²,

Emeto³

et al. 2010

Current Problems in Cardiology

130

148

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Abdominal aortic aneurysm (AAA) remains an important cause of morbidity and mortality in elderly men, and prevalence is predicted to increase in parallel with a global ageing population. AAA is commonly asymptomatic, and in the absence of routine screening, diagnosis is usually incidental when imaging to assess unrelated medical complaints. In the absence of approved diagnostic and prognostic markers, AAAs are monitored conservatively via medical imaging until aortic diameter approaches 50-55mm and surgical repair is performed. There is currently significant interest in identifying molecular markers of diagnostic and prognostic value for AAA. Here we outline the current guidelines for AAA management, and discuss modern scientific techniques currently employed to identify improved diagnostic and prognostic markers. KeywordsAbdominal aortic aneurysm; diagnosis; prognosis; biomarker INTRODUCTIONAn abdominal aortic aneurysm (AAA) is a dilation of the infra-renal aorta, which appears to result from chronic weakening of the arterial wall, increasing the risk of fatal rupture.1 -3 AAA is also associated with an increased risk of other major cardiovascular events in aneurysmal patients. For example the UK small aneurysm trial (UKSAT), demonstrated that only 16% of deaths in patients with 40-55mm AAAs was related to AAA repair or rupture while ~50% were due to other cardiovascular causes (mainly myocardial infarction and stroke).4 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access AAA pathologyMacroscopically, an AAA can be considered a dilatation of the infrarenal aorta, giving rise to a permanent vessel diameter >30mm (typical abdominal aortic diameter ranges from 15 to 25mm). 23-27 AAA vessel dilation is commonly progressive, and is often accompanied by the formation of a laminated, non-occlusive, intraluminal thrombus.28 -29 Thrombus size and location varies between patients, and the arterial wall may be partially or completely covered by the thrombus ( Figure 1A and B). 30 The thrombus remains in permanent contact with circulating blood and is continually remodeled, 31,32 and thrombus size increases in parallel with aortic dilation. Due to constant remodeling the thrombus is a laminated structure comprising a red blood cell-rich luminal layer in contact with the flowing blood, progressing to a brown fibrinolysed layer at the aortic wall. 29 Localised hypoxia has been demonstrated in regions of the aorta covered by the thrombus and this has been suggested to contribute to physiological stresses within the arterial wall. 33 Similar to other vascular dise...

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“…Five studies have reported the effects of EVAR on hemostasis 20,68,[77][78][79] (Table VI). Serino et al 79 reported the short-term effects of EVAR on circulating D-dimer levels in nine patients assessed preoperatively and day 4 postoperatively. D-dimer levels were elevated in seven patients and decreased in two patients.…”

Section: Reported An Independent Association Betweenmentioning

confidence: 99%

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

Davies

Abdelhamid

Wall

et al. 2011

Journal of Vascular Surgery

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Noninvasive Diagnosis of Incomplete Endovascular Aneurysm Repair: D-Dimer Assay to Detect Type I Endoleaks and Nonshrinking Aneurysms

Abstract: Elevated D-D may prove to be a useful marker for fixation problems after endovascular AAA repair and may help rule out type I endoleak, thus excluding patients from unnecessary invasive tests.

Cited by 21 publications

References 26 publications

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size

Diagnosis and Monitoring of Abdominal Aortic Aneurysm: Current Status and Future Prospects

Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm

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