B-phenylated o-carboranes and its chromium derivatives: Synthesis, electrochemical properties, and X-ray structural studies

1,2-Diphenyl-o-carborane and Its Chromium Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Evaluations

“…As shown in Figure 3 , the chromium atom of compound 2 was coordinated to the phenyl ring of the carbon atom of o -carborane via a π-bond, similar to the previous results [ 8 , 9 ]. The chromium metal adopted the typical three-legged “piano stool” geometry, with the expected geometrical parameters.…”

“…Interestingly, the C1–C2 bond length of 3 was shorter than that of 1 and 2 . It was shown that the contraction of this bond was due to a favorable phenyl ring π*, and carboranyl σ* orbital interactions did not occur in 3 , as has been observed in previous results [ 8 , 9 ]. As shown in Table 2 and Table S9 , the torsion angles of the phenyl rings of 1 and 3 or 2 and 3 changed upon coordination with the chromium atoms.…”

“…These results show that the introduction of phenyl groups or chromium metals into the carborane backbone increases cytotoxicity rather than increasing boron accumulation in cancer cells. As shown in Figure 3, the chromium atom of compound 2 was coordinated to the phenyl ring of the carbon atom of o-carborane via a π-bond, similar to the previous results [8,9]. The chromium metal adopted the typical three-legged "piano stool" geometry, with the expected geometrical parameters.…”

“…We previously reported the detailed synthesis of the compounds Ph3C2B , Ph3C2BCr2 , and Ph3C2BCr3 [ 8 , 9 ]. Compound 1 was synthesized by a procedure modified according to previous results [ 19 , 20 ], as shown in Scheme 1 .…”

“…Recently, as shown in Figure 1, we reported the successful synthesis and structural characterization of 1,2,3-triphenyl-o-carborane and the corresponding chromium complexes (Ph3C2B, Ph3C2BCr2, and Ph3C2BCr3) [8,9]. Among the transition-metal π-complexes, η 6 arene chromium(0) tricarbonyl complexes have been the subject of extensive development due to their significant applications in organic synthesis [10,11].…”