<b>Prognostic significance of the various classifications for parapharyngeal space involvement in nasopharyngeal carcinoma</b>

Huang, Pei Yu; Sun, Zhe; Xie, Chuan; Chen, Qiu Yan; Wen, Yangping; Li, Juan; Qiu, Hui; Liu, Huai; Zhong, Zong Liang; Qiang, Hai; Mo, Hao Yuan

doi:10.3109/00016489.2012.691211

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…In previous studies, primary tumor volume and invasion of the parapharyngeal space were found to be closely related to NPC survival rates [10], [11], [12]. Thus, tumor volume and parapharyngeal space invasion may represent prognostic factors that could be incorporated into the existing TNM system based on the accessibility of US for tumor detection [13], [14]. However, additional studies will be needed to further evaluate this possibility.…”

Section: Discussionmentioning

confidence: 96%

The Diagnostic Accuracy of Ultrasonography versus Endoscopy for Primary Nasopharyngeal Carcinoma

et al. 2014

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ObjectiveTo compare the accuracy of ultrasonography (US) with the current clinical standard of endoscopy for a diagnosis of nasopharyngeal carcinoma (NPC).MethodsA total of 150 patients suspected of having NPC underwent US and endoscopy. A diagnosis was obtained from an endoscopic biopsy collected from each suspected tumor and was compared with a biopsy obtained from a normal nasopharynx. The diagnostic accuracy of US and endoscopy for NPC was evaluated using receiver operating curve (ROC) analysis performed by MedCalc Software.ResultsThe sensitivity, specificity, and accuracy of US versus endoscopy for this cohort were 90.1%, 84.8%, and 87.3% for US, and 88.7%, 97.5%, and 93.3% for endoscopy, respectively. Both US and endoscopy exhibited good diagnostic accuracy for NPC with area under the curve (AUC) values of 0.929 and 0.938, respectively. However, this difference was not significant (Z = 0.36, P = 0.72).ConclusionUS is a useful tool for the detection of tumors in endoscopically suspicious nasopharynx tissues, and also for the detection of subclinical tumors in endoscopically normal nasopharynx tissues.

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Section: Discussionmentioning

confidence: 96%

The Diagnostic Accuracy of Ultrasonography versus Endoscopy for Primary Nasopharyngeal Carcinoma

et al. 2014

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“…Parapharyngeal tumor involvement, especially in the carotid area, is a stronger predictor for poor prognosis [15,16]. Even after the introduction of faciocervical fields, the prognostic value of parapharyngeal involvement remained varied in different studies, mainly because the boost in the parapharyngeal area was not adopted in all the institutions [17][18][19][20][21]. However, with the prevailing use of MRI, CT simulation, and 3D-CRT or IMRT, the possibility of inadequate dose in this area was reduced, and parapharyngeal space extension per se no longer predicts disease outcome [5,22,23].…”

Section: Mri Was Considered As the Preferred Imaging Modality For Npcmentioning

confidence: 99%

Report on revision of the Chinese 1992 staging system for nasopharyngeal carcinoma

Lu²,

Hong³

et al. 2013

J Radiat Oncol

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With the advances of diagnostic imaging and radiation therapy technology, the limitations of the Chinese 1992 staging system for nasopharyngeal carcinoma (NPC) become obvious, and the revision of this system was clearly needed. On December 16, 2008, the Chinese Committee for Staging of Nasopharyngeal Carcinoma (CCSNPC) was inaugurated in Guangzhou, China, with the purpose of establishing a platform for the study of the Chinese staging system and ensuring the continuity of the work of NPC staging research. Data from published studies on staging of NPC were collected and reviewed. After extensive evaluation and discussion, the Chinese 2008 staging system for NPC, which was a consensus based on evidence-based medicine and revisions made on the Chinese 1992 staging system, was recommended by CCSNPC. Changes of the staging system including emphasizing the status of MRI in diagnosis and staging; classification of parapharyngeal involvement, cranial nerve involvement, and retropharyngeal lymph node involvement; and T classification in the new system were simplified as well. CCSNPC also proposed a new criterion of the N category. This review discusses the rationale and bases of our primary revisions of this system and proposes an updated system, named the Chinese 2008 staging system for NPC. Further investigations are needed to confirm the effectiveness as well as to provide basis for further improvement of this system.

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“…It is generally accepted that NPC has a better prognosis with radiotherapy as the first-line therapy, but has reached a plateau at the indicated doses [5,6]. Consequently, there is an urgent need to develop novel radiosensitizers to achieve better curative effect, without increasing radiation injury.…”

Section: Introductionmentioning

confidence: 99%

Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression

Zhang

Yang

et al. 2013

Acta Oto-Laryngologica

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Prognostic significance of the various classifications for parapharyngeal space involvement in nasopharyngeal carcinoma

Cited by 8 publications

References 17 publications

The Diagnostic Accuracy of Ultrasonography versus Endoscopy for Primary Nasopharyngeal Carcinoma

The Diagnostic Accuracy of Ultrasonography versus Endoscopy for Primary Nasopharyngeal Carcinoma

Report on revision of the Chinese 1992 staging system for nasopharyngeal carcinoma

Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression

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