<b>Recovery Curve and Concealed Conduction in the His‐Purkinje System of the Rabbit Heart</b>: Effects of Radiofrequency Modification of the Low AV Junction

Sanchís, Juan; Chorro, Francisco J.; Such, Luis; Artal, Leandro; Bodı́, Vicente; Atienza, Felipe; Llavador, Esteban; Llavador, J; Merino, Vicente López

doi:10.1111/j.1540-8159.1996.tb04788.x

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recordings were made at 100 mm/s, with a measurement precision of 1 ms. In previous studies, our laboratory checked the reproducibility of the measurements (16,17).…”

Section: Methodsmentioning

confidence: 99%

Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart

Such

Rodriguez

Alberola

et al. 2002

Journal of Applied Physiology

View full text Add to dashboard Cite

We have studied the intrinsic modifications on myocardial automatism, conduction, and refractoriness produced by chronic exercise. Experiments were performed on isolated rabbit hearts. Trained animals were submitted to exercise on a treadmill. The parameters investigated were 1) R-R interval, noncorrected and corrected sinus node recovery time (SNRT) as automatism index; 2) sinoatrial conduction time; 3) Wenckebach cycle length (WCL) and retrograde WCL, as atrioventricular (A-V) and ventriculoatrial conduction index; and 4) effective and functional refractory periods of left ventricle, A-V node, and ventriculoatrial retrograde conduction system. Measurements were also performed on coronary flow, weight of the hearts, and thiobarbituric acid reagent substances and glutathione in myocardium, quadriceps femoris muscle, liver, and kidney, to analyze whether these substances related to oxidative stress were modified by training. The following parameters were larger (P < 0.05) in trained vs. untrained animals: R-R interval (365 +/- 49 vs. 286 +/- 60 ms), WCL (177 +/- 20 vs. 146 +/- 32 ms), and functional refractory period of the left ventricle (172 +/- 27 vs. 141 +/- 5 ms). Corrected SNRT was not different between groups despite the larger noncorrected SNRT obtained in trained animals. Thus training depresses sinus chronotropism, A-V nodal conduction, and increases ventricular refractoriness by intrinsic mechanisms, which do not involve changes in myocardial mass and/or coronary flow.

show abstract

“…The recordings were made at 100 mm/s, with a measurement precision of 1 ms. In previous studies, our laboratory checked the reproducibility of the measurements (16,17).…”

Section: Methodsmentioning

confidence: 99%

Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart

Such

Rodriguez

Alberola

et al. 2002

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

Modification of Atrioventricular Nodal Electrophysiology by Selective Radiofrequency Delivery on the Anterior or Posterior Approaches

Chorro¹,

Sanchis²,

Such

et al. 1997

Pacing Clinical Electrophis

Self Cite

View full text Add to dashboard Cite

An analysis was made in 14 isolated and perfused rabbit hearts of the electrophysiological effects of selective radiofrequency (RF) delivery in the anterior (group I, n = 7) or posterior zone (group II, n = 7) of the Koch triangle, with the aim of modifying atrioventricular nodal (AVN) conduction without suppressing 1:1 transmission. After opening the right atrium, RF was delivered (0.5 W) with a 1-mm diameter unipolar electrode positioned in the selected zone until a prolongation of no less than 15% was obtained in the Wenckebach cycle length (WCL). Before and after (30 min) RF, anterograde and retrograde AVN refractoriness and conduction were evaluated, stimulating from the crista terminalis (CT), the interatrial septum (IAS), and from the RV epicardium. After RF, the following percentage increments were observed in group I: AH(CT) = 36% +/- 9%, AH(IAS) = 38% +/- 11%, WCL(CT) = 28% +/- 8%, WCL(IAS) = 22% +/- 6%, functional refractory period (FRP) of the AVN(CT) = 13% +/- 11%, FRP-AVN(IAS) = 13% +/- 8%, retrograde WCL = 20% +/- 19%, and retrograde FRPVA = 13% +/- 16%. The increments observed in group II and the significances of the differences with respect to group I were: AH(CT) = 11% +/- 14% (P < 0.01), AH(IAS) = 19% +/- 32% (NS), WCL(CT) = 42% +/- 14% (P < 0.05), WCL(IAS) = 42% +/- 16% (P < 0.01), FRP-AVN(CT) = 28% +/- 28% (NS), FRP-AVN(LAS) = 21% +/- 19% (NS), retrograde WCL = 35% +/- 24% (NS), and retrograde FRP = 16% +/- 13% (NS). In both groups, the AH interval variations were not correlated with those of the rest of the parameters analyzed. Truncated nodal function curves suggestive of a dual AV nodal pathway were obtained in three experiments, though in only one of them was this observed under basal conditions. In the other two experiments, with dual AV nodal physiology only after RF (one from each group), AV nodal reentrant tachycardias were triggered with atrial extrastimulus at coupling intervals equal to or shorter than at those that cause a sudden lengthening of the AH interval, RF delivered in the anterior and posterior zones of the Koch triangle produced effects of different magnitude on the AH interval and Wenckebach cycle length. In the anterior zone the AH interval was prolonged to a greater extent, while in the posterior zone the effects were greater on the Wenckebach cycle length. No correlation existed between the variations in AH interval and Wenckebach cycle length, regardless of where RF was delivered. The evaluation of anterograde AV nodal refractoriness was similar when stimulating from the crista terminalis or from the interatrial septum. By delivering RF, it was possible to induce dual AV nodal physiology and reentrant tachycardias.

show abstract

Recovery Curve and Concealed Conduction in the His‐Purkinje System of the Rabbit Heart: Effects of Radiofrequency Modification of the Low AV Junction

Cited by 2 publications

References 15 publications

Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart

Intrinsic changes on automatism, conduction, and refractoriness by exercise in isolated rabbit heart

Modification of Atrioventricular Nodal Electrophysiology by Selective Radiofrequency Delivery on the Anterior or Posterior Approaches

Contact Info

Product

Resources

About