<b>Sequence Note</b>: HIV Type 1 Subtypes in Argentina and Genetic Heterogeneity of the V3 Region

Campodonico, Miguel A.; Janssens, Wouter; Heyndrickx, L; Fransen, Katrien; Leonaers, A.; Fay, Fabián; Taborda, Miguel A.; Groen, G van der; Fay, Oscar

doi:10.1089/aid.1996.12.79

Cited by 37 publications

(30 citation statements)

References 5 publications

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“…Subtypes of all 24 patients were also tested by HMA. [Campodonico et al(1996) Penny et a1.(1996)]. Another env sequence from this same patient was determined by a second group.…”

Section: Notementioning

confidence: 99%

See 1 more Smart Citation

Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

Myers¹,

Foley²,

Korber

et al. 1997

366

678

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“…Subtypes of all 24 patients were also tested by HMA. [Campodonico et al(1996) Penny et a1.(1996)]. Another env sequence from this same patient was determined by a second group.…”

Section: Notementioning

confidence: 99%

“…Subtypes of all 24 patients were tested by HMA. [Campodonico et al(1996)]. GenBank accession numbers U37030, U37031 and U37034-U37042.…”

Section: B Subtypementioning

confidence: 99%

Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

Myers¹,

Foley²,

Korber

et al. 1997

366

678

View full text Add to dashboard Cite

“…Subtypes of all 24 patients were tested by HMA. [Campodonico et al(1996)]. Accession numbers U37030, U37031 and U37034-U37042.…”

Section: B Subtypementioning

confidence: 99%

“…Subtypes of all 24 patients were also tested by HMA. [Campodonico et al(1996) [Potts et al(1993b)]. Accession number L19237.…”

Section: Receptorsmentioning

confidence: 99%

Human Retroviruses and Aids - 1999

Kuiken¹,

Foley²

1999

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“…In the 1990s, the env gene (V3 and C2-V3) was mostly used to characterize the circulating HIV-1 subtypes in Buenos Aires and Rosario cities; these studies detected the presence of subtypes B and F, with subtype B as the most abundant 4,5,6 . The full-length sequencing allowed the characterization of the recombinant CRF12_B/F1 together with other diverse URF_B/F1 7,8 , showing that almost all F1 strains, according to the env gene, were in fact recombinant forms with breaking points with subtype B in the pol gene.…”

Section: Introductionmentioning

confidence: 99%

Caracterización de los subtipos de VIH-1 presentes en Córdoba (Argentina) desde casi el inicio de la infección, utilizando los genes POL y ENV

Ittig

Lucca

Caeiro

et al. 2017

Rev Fac Cien Med Univ Nac Cordoba

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Abstract:Objective: In the present study we characterize, using a retrospective approach, the HIV-1 infection in Córdoba, Argentina, by determining the viral subtypes circulating in the period 1986-2001. Methods: The pol and env genes were analyzed using two different approaches: 1) comparing the sequences from Córdoba with those of pure subtypes and circulating recombinant forms of the HIV-1 M group; 2) subdividing the sequences into pure-subtype data sets (avoiding the effects of recombination) to determine if the subtypes from Córdoba have a single or multiple geographic origins. Results: The first approach revealed that eighteen strains were subtype B, seven B/F1, one C and one F1. Only two of the B/F1 corresponded to the CRF12_B/F1, previously described for Argentina; the remaining B/F1 sequences could be considered different forms of URF_B/F1. The Phylogenetic results of the second approach suggest that in Córdoba subtype B would have multiple geographic origins, while subtypes F1 and C would have been introduced directly from Brazil or indirectly from Buenos Aires. Conclusions: The great subtype variability indicates that the HIV-1 infection in Córdoba was complex since its very beginning. Our results also reveal the close contact of people of this city, through tourism and commercial activities, with those from Buenos Aires and Brazil. Keywords:HIV-1 infection; Córdoba, Argentina; HIV-1 subtypes; phylogenetic analyses; inter subtype recombinant strains Resumen:Objetivo: En el presente estudio, utilizando un enfoque retrospectivo, caracterizamos la infección de VIH-1 en Córdoba (Argentina) a través de la determinación de los subtipos virales circulantes en el período 1986-2001. Métodos: Se analizaron los genes pol y env utilizando dos enfoques diferentes: 1) comparando las secuencias de Córdoba con aquellas de subtipos puros y formas recombinantes circulantes del grupo M del VIH-1; 2) subdividiendo las secuencias en matrices de subtipos puros (evitando los efectos de la recombinación) a fin de determinar si los subtipos de Córdoba tienen uno o varios orígenes geográficos. Resultados: El primer enfoque reveló que dieciocho cepas correspondían al subtipo B, siete a B/F1, una a C y una a F1. Solo dos de los B/F1 correspondían a la forma CRF12_B/F1, previamente descripta para Argentina; las secuencias B/F1 restantes serían diferentes formas de URF_B/F1. Los análisis filogenéticos del segundo enfoque sugieren que el subtipo B de Córdoba tendría múltiples orígenes geográficos, mientras que los subtipos F1 y C habrían sido introducidos directamente desde Brasil o indirectamente desde Buenos Aires. Conclusiones: La gran variabilidad de subtipos indica que la infección de VIH-1 en Córdoba fue compleja desde sus inicios. Nuestros resultados también revelan el estrecho contacto entre la gente de esta ciudad, a través del turismo y actividades comerciales, con las de Buenos Aires y Brasil.

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Sequence Note: HIV Type 1 Subtypes in Argentina and Genetic Heterogeneity of the V3 Region

Cited by 37 publications

References 5 publications

Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences

Human Retroviruses and Aids - 1999

Caracterización de los subtipos de VIH-1 presentes en Córdoba (Argentina) desde casi el inicio de la infección, utilizando los genes POL y ENV

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