B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation

Abstract

BNP is a useful adjunct to standard cardiac markers in patients presenting to the emergency department with chest pain and no ST-segment elevation, particularly if initial CKMB and/or troponin-I are non-diagnostic.

The Role of N terminal pro-BNP in assessing severity of Coronary Artery Disease: a prospective study

“…Thus, higher baseline levels of NT proB-NP was directly associated with age i.e. patients with NTproBNP > 258pg/ml were older (median age 68 yrs).These finding were consistent with earlier studies by Sadanandan S. et al, Morrow DA et al and Bassan R et al, who also reported that higher level of BNP was seen in older patients (10,11,12).Out of 72 cases NSTEACS was seen in 56 (77.7%) of cases and UA was seen in 16(22.3%) of cases. Both UA/NSTEACS were seen predominantly in males.…”

“…This finding was consistent with earlier studies by Bassan R et al Lindahl et al and Heeschen. (12,(14)(15). Diabetes, hypertension smoking and dyslipedemia were seen more in NSTEACS group than in UA patients but difference was not statistically significant (Table-3).…”

“…BNP is a peptide consisting of 2 aminoacids produced by the myocytes as a prohormone. It is released as a response to ventricular dilatation and pressure overload in its active form after peptidases degradation, into the cardiovascular system (3). BNP levels are increased after myocardial infarction and high levels are related to increased risk of adverse events.…”

“…The Role of N terminal pro-BNP in assessing severity of Coronary Artery Disease: a prospective study Int J Car & Hear Heal. 1:3, 43-49 setting of acute coronary syndrome (ACS) are associated with poor prognosis, including increased mortality, development of congestive heart failure (CHF), and recurrent ischemic events (3,7,8). Several studies in ACS patients demonstrated a strong association between increased NT PRO BNP and poor clinical outcome however the underlying mechanism responsible for this association is unclear: BNP and NTPROBNP could be indicators for multivessel disease, poor TIMI flow as well as markers of coronary disease extension (5,7).…”

Does admission NT-proBNP increase the prognostic accuracy of GRACE risk score in the prediction of short-term mortality after acute coronary syndromes?

“…Myocardial cell death (and the release of its necrosis markers) is a final event (3). BNP was found to be very useful in the emergency department for the diagnosis of acute MI in patients with chest pain, particularly when standard cardiac markers are non-diagnostic (14). In fact, BNP has been found to increase in the setting of MI with peak levels occurring 14 to 40 h after the ischemic event (4).…”