B-Type Natriuretic Peptide Predicts Adverse Cardiovascular Events in Pediatric Outpatients With Chronic Left Ventricular Systolic Dysfunction

Price, Jack F.; Thomas, A.; Grenier, Michelle A.; Eidem, Benjamin W.; Smith, E. O’Brian; Denfield, Susan W.; Towbin, Jeffrey A.; Dreyer, William J.

doi:10.1161/circulationaha.105.608869

Cited by 157 publications

(102 citation statements)

References 37 publications

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“…In line with our outcomes Price et al in a study pointed out that BNP concentrations increase in children with chronic LV systolic dysfunction and predict the 90-day composite end point of death, hospitalization, or listing for cardiac transplantation 26 .…”

Section: Discussionsupporting

confidence: 90%

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Does B-type Natriuretic Peptide Level Predict Outcome After Arterial Switch Operation ?

Totonchi¹,

Ghorbanlou²,

Kiaei³

et al. 2016

Biosci., Biotech. Res. Asia

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Evaluation the predictive value of perioperative Plasma B-type natriuretic peptide level in arterial switch operation. Plasma B-type natriuretic peptide level was measured before and and 24 hours after surgery in 29 patients with arterial switch operation. We evaluated 29 patients (22 male,76%,7 female 24%) with mean age 67.93±84.09 days (range 6 days to 14months).The mean of BNP level before surgery was 7989.96±9691.94 and increased after surgery to 22391.35±11898.67 and difference between two groups was significant (P=0.003).In linear regression test the BNP did not correlate with sex(r=0.33, P=0.085) and age(r=0.14,P=0.45). Furthermore, BNP did not correlate with duration of mechanical ventilation (r=0.132,P=0.53) , ICU stay (r=0.137,P=0.52) and with lactate level (r=0.41,P=0.054)after operation. During the study 4 patients(13.8%) died and the mean of BNP 24h after operation among them was 35000.00±00.00.using chai-square and fisher exact test the correlation between BNP and death was significant(P=0.001). We implied that BNP level increased 24 hours after arterial switch operation, moreover we denoted it correlated well with the death rate and an increase in B-type natriuretic peptide 24 hours after surgery predicts poor postoperative outcome. However it did not correlate with duration of mechanical ventilation ,ICU stay and lactate level in this patients.

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Section: Discussionsupporting

confidence: 90%

“…BNP is a 32-amino acid polypeptide hormone, with diuretic, natriuretic, and vasoactive actions, and use as a biomarker for the management of cardiac disease in both pediatric and adults' patients [1][2][3][4] .…”

mentioning

confidence: 99%

Does B-type Natriuretic Peptide Level Predict Outcome After Arterial Switch Operation ?

Totonchi¹,

Ghorbanlou²,

Kiaei³

et al. 2016

Biosci., Biotech. Res. Asia

View full text Add to dashboard Cite

show abstract

“…18 -20 A BNP level Ͼ300 pg/mL has been shown to predict death, transplantation, or heart failure hospitalization and was more strongly correlated with poor outcome than symptoms or echocardiographic findings. 20 BNP levels can be different in children with DCM and congenital heart disease, despite similar New York Heart Association class, ejection fraction, and maximal oxygen consumption. 21 If replicated in a larger study, this finding has implications for the interpretation of information on neurohormonal activation in different pediatric populations.…”

Section: Neurohormonal Activationmentioning

confidence: 93%

Heart Failure in Children

Hsu

Pearson

2009

Circ: Heart Failure

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“…(37) Also, BNP and NT-proBNP levels are higher in children with newly diagnosed heart failure or those with acute exacerbations of chronic heart failure; higher BNP levels predict poor prognosis; improved BNP levels suggest improved ventricular function; following complex heart surgery, BNP is predictive of heart failure and BNP might be helpful as a marker of anthracycline induced myocardial toxicity. (38)(39)(40)(41)(42)(43) Other studies…”

Section: Creatinine Kinase and Troponinmentioning

confidence: 99%

Aetiology, diagnosis and management of heart failure in infants and children

Pepeta

2017

SAHJ

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B-Type Natriuretic Peptide Predicts Adverse Cardiovascular Events in Pediatric Outpatients With Chronic Left Ventricular Systolic Dysfunction

Abstract: Background-Plasma B-type natriuretic peptide (BNP) levels are elevated in adults with heart failure and correlate with functional classification and prognosis. The range and predictive power of BNP concentrations in children with chronic heart failure, however, are not known.

Cited by 157 publications

References 37 publications

Does B-type Natriuretic Peptide Level Predict Outcome After Arterial Switch Operation ?

Does B-type Natriuretic Peptide Level Predict Outcome After Arterial Switch Operation ?

Heart Failure in Children

Aetiology, diagnosis and management of heart failure in infants and children

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