B-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer

“…We hope, therefore, that these methods will be included in future phantom studies. Finally, the choice of b‐values was probably not optimal; b‐value optimization may improve IVIM estimates 30,31 …”

Section: Discussionmentioning

confidence: 99%

Repeatability of IVIM biomarkers from diffusion‐weighted MRI in head and neck: Bayesian probability versus neural network

Koopman

Martens

Gurney‐Champion

et al. 2021

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…In our study, a large sample size of 184 patients was analyzed, and thus, the results based on the optimal threshold b values were more persuasive for the detection of the axSpA activity in sacroiliitis. Previous studies confirmed that, with a carefully selected threshold b value, the error could be reduced in the measurement of parameters from IVIM DWI [ 22 , 23 ]. However, it is demonstrated that the optimal threshold b value is dependent on the location of the body, such as 40 s/mm 2 in breast cancer and 100 s/mm 2 in cervical adenocarcinoma [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 82%

Improved Performance of Compartments in Detecting the Activity of Axial Spondyloarthritis Based on IVIM DWI with Optimized Threshold $b$ Value

Xie

Guo

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Purpose. To explore the diagnostic performance of the optimized threshold b values on IVIM to detect the activity in axial spondyloarthritis (axSpA) patients. Method. 40 axSpA patients in the active group, 144 axSpA patients in the inactive group, and 20 healthy volunteers were used to evaluate the tissue diffusion coefficient ( D slow ), perfusion fraction ( f ), and pseudodiffusion coefficient ( D fast ) with b thresholds of 10, 20, and 30 s/mm2. The Kruskal-Wallis test and one way ANOVA test was used to compare the different activity among the three groups in axSpA patients, and receiver operating characteristic (ROC) curve analysis was applied to evaluate the performance for D slow , f , and D fast to detect the activity in axSpA patients, respectively. Results. D slow demonstrated a statistical difference between two groups ( P < 0.05 ) with all threshold b values. With the threshold b value of 30 s/mm2, f could discriminate the active from control groups ( P < 0.05 ). D slow had similar performance between the active and the inactive groups with threshold b values of 10, 20, and 30 s/mm2 (AUC: 0.877, 0.882, and 0.881, respectively, all P < 0.017 ). Using the optimized threshold b value of 30 s/mm2, f showed the best performance to separate the active from the inactive and the control groups with AUC of 0.613 and 0.738 (both P < 0.017 ) among all threshold b values. Conclusion. D slow and f exhibited increased diagnostic performance using the optimized threshold b value of 30 s/mm2 compared with 10 and 20 s/mm2, whereas D fast did not.

show abstract

“…In our study, there was a significant difference in the D value of the PMI-positive and PMI-negative groups. Perucho et al [ 25 ] showed that high FIGO stages had higher D ∗ values than low stages, but D values had no significance in distinguishing between high and low stages. The D value, excluding the low b value perfusion, represents pure water molecule diffusion of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Combined Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Diffusion Tensor Imaging in Predicting Parametrial Infiltration in Cervical Cancer

Lin

et al. 2021

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

Objective. This study sought to determine the diagnostic value of combined intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) in predicting parametrial infiltration (PMI) in patients with cervical cancer. Materials and Methods. We enrolled 65 patients with cervical cancer confirmed by radical hysterectomy (25 PMI-negative and 40 PMI-positive) who underwent IVIM and DTI pretreatment. The parameters of IVIM (ADC, D, D ∗ , and f) and DTI (average diffusion coefficient (DCavg) and fractional anisotropy (FA)) were recorded by two observers. All parameter differences were tested, and the receiver operating characteristic (ROC) curves were generated to estimate the diagnostic performance of significant metrics and their combinations. Results. Compared to the PMI-negative group, the PMI-positive group had significantly lower D (0.632 ± 0.017 vs. 0.773 ± 0.024, p < 0.001 ) and lower FA (0.073 ± 0.002 vs. 0.085 ± 0.003, p = 0.003 ). The area under the ROC curve (AUC) of D and FA was 0.801 and 0.726, respectively, and the combination of D and FA improved the AUC to 0.931, with a sensitivity and specificity of 80.0% and 97.5%, respectively. Conclusion. D and FA values could be used to help diagnose PMI in patients with cervical cancer. The combination of IVIM and DTI was more valuable than either option alone.

show abstract

B-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer

Abstract: Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) are useful for evaluating and characterizing the primary tumor in cervical cancer (1), assessing metastatic lymph node involvement (2), and monitoring treatment response (3-5). However, the

Cited by 20 publications

References 41 publications

Repeatability of IVIM biomarkers from diffusion‐weighted MRI in head and neck: Bayesian probability versus neural network

Repeatability of IVIM biomarkers from diffusion‐weighted MRI in head and neck: Bayesian probability versus neural network

Improved Performance of Compartments in Detecting the Activity of Axial Spondyloarthritis Based on IVIM DWI with Optimized Threshold $b$ Value

Diagnostic Value of Combined Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Diffusion Tensor Imaging in Predicting Parametrial Infiltration in Cervical Cancer

Contact Info

Product

Resources

About

B-Value Optimization in the Estimation of Intravoxel Incoherent Motion Parameters in Patients with Cervical Cancer

Abstract: Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) are useful for evaluating and characterizing the primary tumor in cervical cancer (1), assessing metastatic lymph node involvement (2), and monitoring treatment response (3-5). However, the

Cited by 20 publications

References 41 publications

Repeatability of IVIM biomarkers from diffusion‐weighted MRI in head and neck: Bayesian probability versus neural network

Repeatability of IVIM biomarkers from diffusion‐weighted MRI in head and neck: Bayesian probability versus neural network

Improved Performance of Compartments in Detecting the Activity of Axial Spondyloarthritis Based on IVIM DWI with Optimized Threshold b Value

Diagnostic Value of Combined Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance Imaging with Diffusion Tensor Imaging in Predicting Parametrial Infiltration in Cervical Cancer

Contact Info

Product

Resources

About

Improved Performance of Compartments in Detecting the Activity of Axial Spondyloarthritis Based on IVIM DWI with Optimized Threshold $b$ Value