B-Vitamins and Homocysteine in Spanish Institutionalized Elderly

Gross, Marcela González; Sola, Ricardo; Albers, Ulrike; Barrios, Laura; Alder, Monika; Castillo, Manuel J.; Pietrzik, Klaus

doi:10.1024/0300-9831.77.1.22

Cited by 37 publications

(38 citation statements)

References 76 publications

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“…Finally, in agreement with Gonzalez-Gross's observation (24), and on the basis of our own experience, given the high prevalence of hyperhomocysteinemia (frequently due to vitamin B deficiency) careful monitoring of the metabolic markers of cobalamin status is suggested (26,27).…”

Section: Discussionsupporting

confidence: 57%

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Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

Bamonti

Moscato

Novembrino

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay. Methods: Determination of the cut-off threshold and correlation between HoloTC and the other diagnostic parameters routinely used for vitamin B 12 deficiency wtotal vitamin B 12 (tB 12 ), folate, homocysteinex were measured in 250 routine blood specimens from 107 men (mean age 59.0"18.8 years) and 143 women (mean age 54.2"23.1 years). The inclusion criterion was serum tB 12 concentration F221 pmol/L. Results: Analytical performance results agreed with those reported by others. A weak correlation (Rs0.42) was found between HoloTC and tB 12 . A 40 pmol/L cut-off threshold was chosen for HoloTC and the associated sensitivity and

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Section: Discussionsupporting

confidence: 57%

“…There is concern about subtle cobalamin deficiency, especially in populations at risk. As reported by Miller et al (23) in a study of an elderly cohort, and confirmed by Gonzalez-Gross et al (24), measurement of both HoloTC and tB 12 concentrations provide better screening for cobalamin deficiency than either assay alone.…”

Section: Discussionmentioning

confidence: 50%

Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

Bamonti

Moscato

Novembrino

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…This may be due to the preparation of samples for RBC folate measurement which requires more laborious steps than for sFolate. Additionally, both folate markers should be measured to assess if there is a mixed deficiency between folate and vitamin B 12 [1]. However, MMA measurement is important to distinguish between vitamin B 12 and folate deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin B 12 levels decreases with age [1], which means that deficiency risk increases in parallel with age [2][3][4]. Therefore, subclinical deficiency is quite more prevalent in the elderly.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, due to the high variability of cut-off values across laboratories, vitamin B 12 deficiency prevalence ranges from 3% for people aged ≥ 3 years to 67.6% for elderly (71-74 years) [12,13]. This prevalence can increase up to 15.8% for institutionalized elderly, which presents a greater risk for vitamin deficiencies than the free-living elderly [1]. Epidemiologic data by Andres et al confirmed that 20% of the elderly present megaloblastic anemia in developed countries [14].…”

Section: Introductionmentioning

confidence: 99%

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A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio‐Ugarriza¹,

Palacios²,

Alder

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

106

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Vitamin B 12 deficit is one of the most common vitamin deficiencies. However, there is no consensus on the cut-off points for vitamin B 12 and its co-markers, such as folate, holotranscobalamin, methylmalonic acid and homocysteine. In order to establish the state of the art about cut-off points used to determine vitamin B 12 deficiency in the last decades, the database MEDLINE was used for searching studies published in adults between December 1992 and May 2014 (69 articles), using search terms like 'vitamin B 12 ', 'cobalamin', 'cut-off', 'deficiency' alone or in combinations. Broad ranges of cut-off points for vitamin B 12 and its biomarkers were identified: vitamin B 12 ranged between 100 pmol/L and 350 pmol/L, holotranscobalamin 20-50 pmol/L, methylmalonic acid 0.210-0.470 μmol/L, homocysteine 10-21.6 μmol/L, serum folate 3.7-15.9 nmol/L and red blood cell 124-397 nmol/L. For the majority of studies, the potential influence of age, analytical methods, gender and fortified food consumption was not taken in account when choosing cut-off values. This could explain the discrepancies between studies on vitamin B 12 and folate deficiency prevalences. We conclude that there is inconsistency in the literature regarding vitamin B 12 cut-offs. It would be necessary to establish different reference cut-offs according to age, considering the analytical methods used.

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Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review

et al. 2021

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Hyperhomocysteinemia is an independent predictor of the risk for cognitive decline and may be a result of low levels of vitamins B 12 , B 6 , and folate. Previous findings suggest that adequate intake of these vitamins may reduce homocysteine levels. This review aimed to assess the effects of treatment with vitamins B 6, B 12 , and/or folic acid in the homocysteine levels in patients with mild cognitive impairment (MCI). A systematic literature review was conducted in EMBASE, MEDLINE ® , PsycINFO, and Cochrane Central Register of Controlled Trials. The research question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: in patients with MCI (P); what is the efficacy of vitamins B 6 , B 12 , and/or folic acid intake (I); compared with baseline values, and/or compared with controls (C); in reducing homocysteine levels from baseline (O). A total of eight primary studies with a total of 1,140 participants were included in the review. Four were randomized controlled trials, one was a quasi-controlled trial, and three were observational studies. All studies included folic acid in their intervention, seven vitamin B 12 , and four vitamin B 6 . Mean (SD) length of the intervention period was 18.8 (19.

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B-Vitamins and Homocysteine in Spanish Institutionalized Elderly

Cited by 37 publications

References 76 publications

Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review

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B-Vitamins and Homocysteine in Spanish Institutionalized Elderly

Cited by 37 publications

References 76 publications

Determination of serum holotranscobalamin concentrations with the AxSYM active B12 assay: cut-off point evaluation in the clinical laboratory

Determination of serum holotranscobalamin concentrations with the AxSYM active B12 assay: cut-off point evaluation in the clinical laboratory

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Impact of supplementation with vitamins B6, B12, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review

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Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

Determination of serum holotranscobalamin concentrations with the AxSYM active B₁₂ assay: cut-off point evaluation in the clinical laboratory

Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review