B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease

Lyon, Peter; Strippoli, V.; Fang, Byron; Cimmino, Luisa

doi:10.3390/nu12092867

Cited by 228 publications

(162 citation statements)

References 208 publications

(242 reference statements)

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“…As this problem was described in an earlier work [33], one should ask another question: how will drinking these juices by the patient affect the cancer treatment during carboplatin therapy? Based on the literature, it can be said that high levels of some B vitamins can cause cancer or accelerate its development [34][35][36]. However, it is widely accepted that eating meals rich in vitamins and minerals, such as carrot and beetroot juice, reduces the likelihood of cancer, prevents it from metastasis, and may even help with cancer therapy.…”

Section: The Motivation Of Workmentioning

confidence: 99%

“…Based on the literature, it can be said that high levels of some B vitamins can cause cancer or accelerate its development [ 34 , 35 , 36 ]. However, it is widely accepted that eating meals rich in vitamins and minerals, such as carrot and beetroot juice, reduces the likelihood of cancer, prevents it from metastasis, and may even help with cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

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The Affinity of Carboplatin to B-Vitamins and Nucleobases

Szefler

Czeleń

Krawczyk

2021

IJMS

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Platinum compounds have found wide application in the treatment of various types of cancer and carboplatin is one of the main platinum-based drugs used as antitumor agents. The anticancer activity of carboplatin arises from interacting with DNA and inducing programmed cell death. However, such interactions may occur with other chemical compounds, such as vitamins containing aromatic rings with lone-pair orbitals, which reduces the anti-cancer effect of carboplatin. The most important aspect of the conducted research was related to the evaluation of carboplatin affinity to vitamins from the B group and the potential impact of such interactions on the reduction of therapeutic capabilities of carboplatin in anticancer therapy. Realized computations, including estimation of Gibbs Free Energies, allowed for the identification of the most reactive molecule, namely vitamin B6 (pyridoxal phosphate). In this case, the computational estimations indicating carboplatin reactivity were confirmed by spectrophotometric measurements.

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Section: The Motivation Of Workmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Affinity of Carboplatin to B-Vitamins and Nucleobases

Szefler

Czeleń

Krawczyk

2021

IJMS

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“…One-carbon metabolism is driven by the folate and requires B 6 as a cofactor. Folate and B 6 together regulate the DNA synthesis and methylation reactions ( 28 ). They play an important role in maintaining the stability of methylation patterns ( 28 ).…”

Section: Discussion Main Findingsmentioning

confidence: 99%

Association Between Dietary Intake of One-Carbon Metabolism-Related Nutrients and Fluorosis in Guizhou, China

Chen

Yang³

et al. 2021

Front. Nutr.

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Objective: This study aimed to investigate the associations between dietary one-carbon metabolism-related nutrients (betaine, choline, methionine, folate, vitamin B6, and vitamin B12) and fluorosis among the Chinese population in an area known for coal-burning fluorosis.Methods: A cross-sectional study was conducted, with 653 fluorosis patients and 241 non-fluorosis participants. Dietary intake was acquired using a validated semi-quantitative 75-item food frequency questionnaire. The risk associations were assessed by unconditional logistical regression.Results: We observed a significant inverse association between dietary betaine, total choline, methionine, folate, vitamin B6, and choline species and fluorosis. The adjusted OR (95% CI) in the highest quartile of consumption compared with the lowest were 0.59 (0.37–0.94) (P-trend = 0.010) for betaine intake, 0.45 (0.28–0.73) (P-trend = 0.001) for total choline intake, 0.45 (0.28–0.72) (P-trend < 0.001) for methionine intake, 0.39 (0.24–0.63) (P-trend < 0.001) for folate intake, 0.38 (0.24–0.62) (P-trend < 0.001) for vitamin B6 intake, and 0.46 (0.28–0.75) (P-trend = 0.001) for total choline plus betaine intake. Dietary intakes of choline-containing compounds, phosphatidylcholine, free choline, glycerophosphocholine, and phosphocholine were also inversely associated with lower fluorosis (all P-trend < 0.05). No significant associations were observed between dietary vitamin B12 or sphingomyelin and fluorosis.Conclusion: The present study suggested that the higher dietary intakes of specific one-carbon metabolism-related nutrients, such as betaine, choline, methionine, folate, and vitamin B6, are associated with lower fluorosis prevalence.

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“…Extensive research has also demonstrated the importance of folate, vitamin 6, and vitamin B12 status in regulating OCM [ 20 , 42 , 43 , 44 , 45 , 46 ]. The classical symptom of folate and vitamin B12 deficiency is megaloblastic anemia caused by inhibition of DNA synthesis in erythropoietic cells in the bone marrow [ 46 ].…”

Section: Description Of the Transsulfuration Pathwaymentioning

confidence: 99%

The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

Werge

McCann

Galsgaard

et al. 2021

JCM

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The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately 25% of the global population may have NAFLD. NAFLD is associated with obesity and metabolic syndrome, but its pathophysiology is complex and only partly understood. The transsulfuration pathway (TSP) is a metabolic pathway regulating homocysteine and cysteine metabolism and is vital in controlling sulfur balance in the organism. Precise control of this pathway is critical for maintenance of optimal cellular function. The TSP is closely linked to other pathways such as the folate and methionine cycles, hydrogen sulfide (H2S) and glutathione (GSH) production. Impaired activity of the TSP will cause an increase in homocysteine and a decrease in cysteine levels. Homocysteine will also be increased due to impairment of the folate and methionine cycles. The key enzymes of the TSP, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE), are highly expressed in the liver and deficient CBS and CSE expression causes hepatic steatosis, inflammation, and fibrosis in animal models. A causative link between the TSP and NAFLD has not been established. However, dysfunctions in the TSP and related pathways, in terms of enzyme expression and the plasma levels of the metabolites (e.g., homocysteine, cystathionine, and cysteine), have been reported in NAFLD and liver cirrhosis in both animal models and humans. Further investigation of the TSP in relation to NAFLD may reveal mechanisms involved in the development and progression of NAFLD.

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B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease

Cited by 228 publications

References 208 publications

The Affinity of Carboplatin to B-Vitamins and Nucleobases

The Affinity of Carboplatin to B-Vitamins and Nucleobases

Association Between Dietary Intake of One-Carbon Metabolism-Related Nutrients and Fluorosis in Guizhou, China

The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

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