B vitamins as a treatment for diabetic pain and neuropathy

Karaganis, Stephen; Song, Xue-Jun

doi:10.1111/jcpt.13375

Cited by 19 publications

(13 citation statements)

References 59 publications

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“…Furthermore, the previous studies on the effect of vitamin B6 supplementation in other types of pain have implied the controversial results [ 26 ]. They do not appear to be comparable with the results of our study in FM because the pain mechanisms in these conditions are different from FM etiopathogenesis and represent a more homogenous nature in each condition rather than FM.…”

Section: Discussionmentioning

confidence: 99%

“…Sadeghi et al showed that 80 mg per day of pyridoxine attenuate the severity and duration of migraine headaches [12]. While some preclinical studies on rats showed the attenuated thalamic evoked nociceptive burst discharge and increased pain threshold, some clinical trials displayed that vitamin B6 monotherapy did not influence diabetic pain and neuropathy [13,25,26]. Ghavidel-Parsa et al BMC Musculoskeletal Disorders (2022) 23:664…”

Section: Discussionmentioning

confidence: 99%

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Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial

Ghavidel‐Parsa

Naeimi

Gharibpoor

et al. 2022

BMC Musculoskelet Disord

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Background Given the role of vitamin B6 on pronociceptive/antinociceptive neurotransmitters balance, metabolic reactions, and inflammation, it is important to clarify the effect of vitamin B6 on pain and psychological disturbance in fibromyalgia (FM). This study aimed to evaluate whether an 80-mg daily dose of vitamin B6 improves pain, disease severity and psychological symptoms of FM compared to a placebo. Methods This randomized, double-blinded, placebo-controlled trial was performed on the FM patients whose diagnosis was confirmed by a rheumatologist based on the 2016 American College of Rheumatology (ACR). 90 Patients were randomized to receive either vitamin B6 (80 mg daily) or placebo in a 1:1 ratio, with a permuted block size of 30 stratified by disease severity. Primary outcomes included the Revised Fibromyalgia Impact Questionnaire (FIQR), Hospital Anxiety and Depression Scale (HADS), 12-item short-form health survey (SF-12), and pain visual analog scale (pain-VAS)). The mean differences in outcomes (before and after treatment) were compared between the vitamin B6 and placebo groups using an independent T-test. An ANCOVA model adjusted for baseline outcome value was also provided to compare the outcomes between the two groups. Results Of 90 eligible patients, 60 patients (31 patients in vitamin B6 and 29 in the placebo group) completed the trial. Overall, the FIQR, pain-VAS, and HADS-anxiety scores improved after treatment in both vitamin B6 and placebo groups; However, there was no statistically significant intergroup difference regarding primary outcomes. ANCOVA model also showed no difference in the treatment effects. Conclusions Our results showed no priority for vitamin B6 over placebo in FM patients. Considering the potential ameliorating role of vitamin B6 on pain and psychological symptoms, acknowledgment of vitamin B6 as a relatively safe adjuvant treatment needs larger future studies. Trial registration Iranian Registry of Clinical Trials: IRCT20200920048782N2 on 2021/10/04.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial

Ghavidel‐Parsa

Naeimi

Gharibpoor

et al. 2022

BMC Musculoskelet Disord

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“…In a review including 5 studies with a total of 348 participants, the evidence on the effects of B vitamins in diabetic polyneuropathy was uncertain [26]. Two reviews [27,28] concluded that vitamins B1, B6 and B12 may have an important role in nerve regeneration with clear disease-modifying mechanisms, but larger RCTs are required for longer periods are needed before these are included in official guidelines.…”

Section: Vitamins Of B-complexmentioning

confidence: 99%

Dietary and Nutritional Supplementation for Painful Diabetic Neuropathy: A Narrative Review

Apergi,

Papanas

2023

Exp Clin Endocrinol Diabetes

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Painful diabetic neuropathy (PDN) is a serious and very common complication of diabetes mellitus (DM). It negatively affects the quality of life, increases morbidity and poses a financial burden on the health care system. Currently, treatment of PDN focuses on glycaemic control, while pathogenesis-oriented therapy has not yielded satisfactory results. The need to improve therapy remains. There is accumulating evidence on the potential benefit of nutritional interventions. The aim of this narrative review was to examine the potential benefit of dietary and nutritional supplementation for PDN management. According to preliminary research, supplementation with vitamin E, B-complex, omega 3 fatty acids, CoQ10 or N-acetylcysteine appears to yield promising results in improving PDN symptoms.

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“…Altogether, it has recently been concluded that the evidence for favorable effects of B vitamins in diabetic neuropathy and neuropathic pain shows substantive heterogeneity with respect to study designs and reported outcomes, highlighting the need for larger, placebo-controlled studies [ 92 ].…”

Section: Diabetic Neuropathymentioning

confidence: 99%

The Role of Biofactors in Diabetic Microvascular Complications

Ziegler

Porta

Παπάνας

et al. 2022

CDR

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: Microvascular complications are responsible for a major proportion of the burden associated with diabetes contributing to substantial morbidity, mortality, and healthcare costs in people with diabetes. Retinopathy, nephropathy, and neuropathy constitute the leading causes of blindness, end-stage renal disease, and lower-extremity amputations, respectively. Since the efficacy of causal therapies of diabetic microvascular complications is limited, especially in type 2 diabetes, there is an unmet need for adjunct treatments which should be effective despite ongoing hyperglycemia. Experimental studies indicate that diabetic microvascular complications can be prevented or ameliorated by various biofactors in animal models by interfering with the pathophysiology of the underlying condition. Some of the findings related to biofactors like α-lipoic acid and benfotiamine could be translated into the clinical arena and confirmed in clinical trials, especially in those focusing on diabetic polyneuropathy. Given the micronutrient nature of these compounds, their safety profile is excellent. Thus, they have the potential to favorably modify the natural history of the underlying complication, but large long-term clinical trials are required to confirm this notion. Ultimately, biofactors should expand our therapeutic armamentarium against these common, debilitating, and even life-threatening sequelae of diabetes.

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B vitamins as a treatment for diabetic pain and neuropathy

Cited by 19 publications

References 59 publications

Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial

Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial

Dietary and Nutritional Supplementation for Painful Diabetic Neuropathy: A Narrative Review

The Role of Biofactors in Diabetic Microvascular Complications

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