Motivated by recent data on B → ppK decay, we study various charmless three-body baryonic B decay modes, including Λpπ, Σ 0p π, ppπ, ppK 0 , in a factorization approach. These modes have rates of order 10 −6 . There are two mechanisms for the production of baryon pairs: current-produced and transition. The behavior of decay spectra from these baryon production mechanisms can be understood by using QCD counting rules. Predictions on rates and decay spectra can be checked in the near future.