B12 levels and frailty syndrome

Pyrgioti, Elisavet E; Karakousis, Nikolaos D

doi:10.22540/jfsf-07-032

Cited by 18 publications

(11 citation statements)

References 36 publications

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“…Практикующие неврологи рекомендуют назначать пиридоксин в дозах, не превышающих 50 мг/сут [23]. Дефицит витамина В 12 рассматривается как фактор риска развития саркопении у лиц пожилого и старческого возраста (снижение функций многих физиологических систем, сопровождающееся уязвимостью к стрессорам), скелетно-мышечных заболеваний, когнитивных нарушений, неврологических и психических симптомов [24]. Когнитивные расстройства, которые являются ключевым признаком хронической ишемии мозга и во многом определяют тяжесть состояния, развиваются не только при структурном поражении центральной нервной системы.…”

Section: терапевтические эффектыunclassified

Vitamins B Effectiveness in Different Nosological Forms

Shavlovskaya¹,

Bokova²

2023

EPh

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B vitamins deserve special attention because they take an active part in the regulation of almost all systems activity, have a neurotropic effect. Among all B vitamins, the most actively used are B1 (thiamine), B6 (pyridoxine), B12 (cobalamin), which are prescribed both in monotherapy and in combination, intramuscularly or orally. Other B vitamins are rarely used alone, only in combination with other vitamins or biologically active supplements (dietary supplements). Thiamine is responsible for the metabolism of nerve tissues, the production of acetylcholine, which participates in carbohydrate metabolism and related energy, fat, protein, water-salt metabolism, has a regulating effect on trophism and the activity of the nervous system. Different forms of vitamin B1 (thiamine disulfide, thiamine hydrochloride, benfotiamine) have an analgesic effect, exhibit an antitumor effect. Pyridoxine exhibits an antioxidant effect, its phosphorylated form (pyridoxal phosphate) participates in the decarboxylation of amino acids, in the formation of physiologically active amines (adrenaline, serotonin, dopamine, tyramine). Polyneuropathy (PNP) of various genesis (diabetic, alcoholic, dysmetabolic) is a target for pyridoxine. Cobalamin is required as a co-factor of the cytosolic methionine synthase reaction and the mitochondrial methymalonyl-CoA mutase reaction. Vitamin B12 deficiency can be manifested by disorders in the hematopoiesis system, PNP, cognitive disorders. Other B vitamins are actively involved in metabolic processes: B2 (riboflavin) is used by the body to metabolize fats, proteins and carbohydrates into glucose for energy, participates in redox processes, the production of red blood cells, B3 (niacin) participates in the processes of anabolism and catabolism, B4 (choline) is necessary for the synthesis of acetylcholine, betaine and phospholipids, B5 (pantothenate) necessary for the synthesis of co-enzyme A, with a deficiency of which severe damage to the basal ganglia region develops, accompanied by progressive cognitive and motor disorders, B7 (biotin), B8 (inositol), B9 (folic acid), B10 (paraaminobenzoic acid) are necessary for normal body functioning. With a combined deficiency of vitamins B1, B2, B6 and B12, there is an increased risk of depression. In the treatment of diseases associated with B vitamins deficiency, a complex of vitamins should be prescribed to enhance the effect.

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Section: терапевтические эффектыunclassified

Vitamins B Effectiveness in Different Nosological Forms

Shavlovskaya¹,

Bokova²

2023

EPh

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“…Screening in older people without other risk factors has been debated and may be warranted, although there is no consensus. 6 Annual testing should be considered for at-risk patients. 7,19,34 CONCOMITANT DEFICIENCIES Vitamin B 12 is closely linked with folate.…”

Section: When To Test For Vitamin B 12 Deficiencymentioning

confidence: 99%

“…In older people, it can also contribute to frailty syndrome. 6 In symptomatic disease, early diagnosis and treatment are important to prevent irreversible damage. 1 The aim of this review is to provide an overview of vitamin B 12 deficiency and its management in older people.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B₁₂ deficiency in older people: a practical approach to recognition and management

Mouchaileh

2023

Pharmacy Practice and Res

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Vitamin B12 deficiency is common in older people and is linked to anaemia, cognitive decline, and dementia. Clinical presentation is variable, ranging from no symptoms or subtle, non‐specific symptoms, through to serious, irreversible neurological symptoms if left untreated. Although common, it is often under‐recognised, with diagnosis usually occurring on incidental blood test screening. Older people are at increased risk of vitamin B12 deficiency due to insufficient dietary intake, malabsorption associated with aged‐related changes in gastrointestinal function, higher incidence of pernicious anaemia, and chronic use of interfering medications such as metformin and proton‐pump inhibitors. Early detection and treatment in symptomatic deficiency are crucial to prevent irreversible damage. Vitamin B12 intramuscular injection bypasses potential absorption issues and is traditionally the first‐line treatment in older people. However, emerging evidence suggests that high‐dose oral replacement may be as effective. Older people often require lifelong therapy due to the irreversible nature of the underlying cause of deficiency. This review provides an overview of vitamin B12 deficiency and its management in older people.

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“…Таким образом, в настоящее время выделяют следующие нарушения, лежащие в основе неврологических проявлений дефицита витамина В 12 [58] Более того, как было показано в нескольких исследованиях, уровни витамина B 12 могут ассоциироваться не только Журнал для непрерывного медицинского образования врачей с неврологическими или когнитивными симптомами, но и со скелетно-мышечными расстройствами и саркопенией, тесно связанными со старческой астенией [59].…”

Section: нарушения лежащие в основе неврологических проявлений дефици...unclassified

Cognitive impairment among patients with diabetes. Role of cobalamin

Антонова¹,

Tanashyan²

2022

Endocrinology: News, Opinions, Training

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Журнал для непрерывного медицинского образования врачей когнитивные нарушения у больных сахарным диабетом. роль кобаламина Федеральное государственное бюджетное научное учреждение «Научный центр неврологии», 125367, г. Москва, Российская Федерация Антонова к.в., танашян м.м. Ключевые слова: сахарный диабет; когнитивные нарушения; цереброваскулярные заболевания; витамин В 12 ; гомоцистеин Сахарный диабет (СД) ассоциирован с повышенным риском развития патологических изменений сосудов головного мозга и когнитивных нарушений (КН). Генез КН у больных СД сложен, ведущая роль отводится цереброваскулярным заболеваниям. Кроме того, велико значение метаболических альтераций, которые не исчерпываются изменением концентраций глюкозы. Удержание гликемического контроля не позволяет добиться значимого положительного влияния на когнитивные функции. Дефициту витамина B 12 , часто выявляемому у больных СД, отводится важная роль в патогенезе КН. В обзоре представлен современный взгляд на механизмы развития нейрокогнитивной дисфункции при СД, в том числе представлены эффекты дефицита кобаламина, обсуждены пути коррекции. Финансирование. Исследование не имело спонсорской поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

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B12 levels and frailty syndrome

Cited by 18 publications

References 36 publications

Vitamins B Effectiveness in Different Nosological Forms

Vitamins B Effectiveness in Different Nosological Forms

Vitamin B₁₂ deficiency in older people: a practical approach to recognition and management

Cognitive impairment among patients with diabetes. Role of cobalamin

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B12 levels and frailty syndrome

Cited by 18 publications

References 36 publications

Vitamins B Effectiveness in Different Nosological Forms

Vitamins B Effectiveness in Different Nosological Forms

Vitamin B12 deficiency in older people: a practical approach to recognition and management

Cognitive impairment among patients with diabetes. Role of cobalamin

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Vitamin B₁₂ deficiency in older people: a practical approach to recognition and management