B407 Frictional property of mature porcine cartilage repaired with a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells

Ogata, Mamoru; Katakai, Daisuke; Nakamura, Norimasa; Ando, Wataru; Fujie, Hiromichi

doi:10.1299/jsmebiofro.2008.19.143

Cited by 1 publication

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“…Friction tests were performed for the specimens in a confined compression fashion on a flat glass plate soaked in saline solution at room temperature using a custom made micro friction tester [5]. The friction speed was 20 mm/s while the normal load was 70, 140, and 280 kPa.…”

Section: Permeability Tests and Friction Testsmentioning

confidence: 99%

Frictional properties of articular cartilage-like tissues repaired with a mesenchymal stem cell-based tissue engineered construct

Fujie

Nakamura

2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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We have been developing a novel tissue engineering technique for cartilage repair using a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells (MSCs). In the present study, the effect of TEC on the repair of chondral defect in the femoral condyle of immature and mature pigs were investigated. The permeability of TEC-treated repaired tissues was significantly higher than normal level at surface layer in immature animals, while the permeability was slightly higher than normal level at middle and deep layers in mature animals. In immature animals, the coefficient of friction of TEC-treated tissues against a glass plate was load-dependently increased, with a significantly higher value than normal level observed at a high load (280 kPa). In contrast, the coefficient of friction was load-dependently decreased in mature animals, with no significant differences from normal level observed at all loads (70, 140, and 280 kPa). It is suggested that the frictional properties of TEC-treated cartilage-like repaired tissues are recovered to normal level in mature animals, while they are unrecovered to normal level due to underdeveloped, permeable surface layer in immature animals.

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Section: Permeability Tests and Friction Testsmentioning

confidence: 99%