B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

Mao, Yiming; Li, Wei; Chen, Kai; Xie, Yufeng; Liu, Qiang; Yao, Min; Duan, Weiming; Zhou, Xiumin; Liang, Rongrui; Tao, Min

doi:10.18632/oncotarget.3097

Cited by 111 publications

(85 citation statements)

References 30 publications

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“…Of these family members, B7-H3 may be of particular interest as a druggable target because it is highly expressed in solid tumors (62) and was shown here to be a negative prognostic feature in nearly every tumor type studied. The latter finding is consistent with previous reports showing that B7-H3 expression is associated with worse outcome in renal cell carcinoma (RCC), prostate cancer, pancreatic carcinoma, NSCLC, and SKCM (63)(64)(65)(66)(67). B7-H3 is thought to down-modulate T-cell responses (68), and may also impede NK-mediated cell lysis (62).…”

Section: Discussionsupporting

confidence: 92%

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Danilova

Wang

Sunshine

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

152

120

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Programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade has led to remarkable and durable objective responses in a number of different tumor types. A better understanding of factors associated with the PD-1/PD-L axis expression is desirable, as it informs their potential role as prognostic and predictive biomarkers and may suggest rational treatment combinations. In the current study, we analyzedPD-L1,PD-L2,PD-1, and cytolytic activity (CYT) expression, as well as mutational density from melanoma and eight other solid tumor types using The Cancer Genome Atlas database. We found that in some tumor types,PD-L2expression is more closely linked toTh1/IFNGexpression and PD-1 and CD8 signaling thanPD-L1. In contrast, mutational load was not correlated with aTh1/IFNGgene signature in any tumor type.PD-L1,PD-L2,PD-1,CYTexpression, and mutational density are all positive prognostic features in melanoma, and conditional inference modeling revealedPD-1/CYTexpression (i.e., an inflamed tumor microenvironment) as the most impactful feature, followed by mutational density. This study elucidates the highly interdependent nature of these parameters, and also indicates that future biomarkers for anti–PD-1/PD-L1 will benefit from tumor-type–specific, integrated, mRNA, protein, and genomic approaches.

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Section: Discussionsupporting

confidence: 92%

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Danilova

Wang

Sunshine

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

152

120

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“…Overexpression of B7-H3 has been associated with multiple cancers including esophageal cancer [41], pancreatic cancer [26], cervical cancer [36], non-small-cell lung cancer [38] and colorectal cancer [37]. However, high B7-H3 expression is also reported to be associated with better survival in acute myeloid leukemia [23].…”

Section: Discussionmentioning

confidence: 99%

“…As members of B7 family, higher B7-H1 expression in human cancer tissues of [51] renal cell carcinoma [52] ovarian cancer [53] non-small cell lung cancer [41], esophageal cancer [54], malignant pleural mesothelioma [55] and colorectal carcinoma [56] is significantly correlated with poor prognosis, while in breast cancer [57], non-small cell lung cancer [58], ovarian cancer [59], renal cell carcinoma [60], pancreatic cancer [26], oral squamous cell carcinoma [61], cholangiocarcinoma [62], hepatocellular carcinoma [63] and esophageal squamous cell carcinoma [64], aberrant expression of B7-H4 has been demonstrated to be associated with a poor clinical outcome. Therefore, we conclude that B7 family members play similar role as negative prognostic factors in tumor development.…”

Section: Discussionmentioning

confidence: 99%

B7-H3 Overexpression Predicts Poor Survival of Cancer Patients: A Meta-Analysis

Zheng

et al. 2016

Cell Physiol Biochem

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Background: B7-H3 exhibits altered expression in various cancers. However, the correlation between B7-H3 expression and prognosis of cancer patients remains controversial. Therefore, we elicit a meta-analysis to investigate the potential value of B7-H3 in the prognostic prediction in human cancers. Materials and Methods: We searched PubMed (last update by June 15th, 2016) to identify studies assessing the effect of B7-H3 on survival of cancer patients. Hazard ratios (HRs) for overall survival (OS), recurrence free survival (RFS) and progression-free survival (PFS) from individual studies were calculated and pooled by using a random-effect or fix-effect model, and heterogeneity and publication bias analyses were also performed. Results: Data from 24 observational studies consisting of 4141 patients were summarized. An elevated baseline B7-H3 was significantly correlated with poor OS (pooled HR = 2.09; 95% CI =1.60-2.74; P < 0.001). Differences across subgroups of tumor type (P = 0.324), year of publication (P = 0.431), ethnicity (P = 0.940), source of HR (P = 0.145), analysis type (P = 0.178) and sample size (P = 0.909) were not significant. Furthermore, high B7-H3 expression also predicted a significantly poor RFS (pooled HR = 1.39; 95% CI = 1.11-1.75; P = 0.004) but not PFS. Conclusions: This meta-analysis clarifies that elevated B7-H3 expression is significantly associated with poor survival in cancer patients.

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“…B7-H3 expression has been overexpressed in various human cancers, and its expression level significantly associated with clinicopathological parameters and survival status of patients, as well as densities of infiltrating immune cell subsets, such as lung cancer [31], renal cancer [32], colorectal cancer [33], and acute leukemia [34]. However, the expression and prognostic role of B7-H3 in ESCC cohort is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma

et al. 2015

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The coinhibitory molecules, B7-H3 and B7-H4, have shown negative regulation in T cell activation and tumor-associated macrophage (TAM) polarization in tumor-specific immunity. Here, we investigated the expression of B7-H3 and B7-H4 in human and murine esophageal squamous cell carcinoma (ESCC) tissues to define their clinical significance and mechanism in a tumor microenvironment. In the present study, B7-H3 and B7-H4 were expressed in 90.6 and 92.7 % samples, respectively. High B7-H3 and B7-H4 expression was associated with advanced TNM stage and lymph node metastasis (p < 0.05, respectively). Patients with both B7-H3 and B7-H4 high-expressed tumors had the poorest prognosis (26.7 months), whereas those with both low-expressed tumors had the best survival (56.7 months). B7-H3 and B7-H4 expression were inclined to be positively related to the infiltration intensity of Treg cells and TAMs (p < 0.05, respectively), and B7-H3 expression is negatively associated with the intensity of CD8(+) T cells (p < 0.05). In 4-nitroquinoline 1-oxide (4-NQO)-induced murine models, high B7-H3 expression could only be detected at carcinoma stage, but abnormal B7-H4 expression appeared a little earlier at dysplasia stage. In vitro studies revealed that knockdown of B7-H3 on tumor cells suppressed ESCC cell migration and invasion, while knockdown of B7-H4 could inhibit ESCC cell growth. Overall, B7-H3 and B7-H4 are involved in ESCC progression and development and their coexpression could be valuable prognostic indicators. Interference of these negative regulatory molecules might be a new strategy for treating ESCC.

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B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

Cited by 111 publications

References 30 publications

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors

B7-H3 Overexpression Predicts Poor Survival of Cancer Patients: A Meta-Analysis

Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma

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