B7-H4 as an independent prognostic indicator of cancer patients: a meta-analysis

Meng, Zhaoqing; Wang, Feiyang; Zhang, Yushun; Li, Shoukang; Wu, Heshui

doi:10.18632/oncotarget.18566

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…33 B7H4 is highly expressed by the majority of human cancers. 34 It has been shown that in PC patients, the expression of B7H1 has an association with tumor size, whereas the expression of B7H4 has associations with tumor size, lymph node metastasis, and depth of invasion. 18 In this metaanalysis, we found that the higher expression of B7H1 or B7H4 was significantly associated with lesser OS.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of B7H1 and B7H4 expression in pancreatic cancer: A meta-analysis

Chen

et al. 2019

Int J Biol Markers

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Objective: The clinical implications of B7H1 and B7H4 in pancreatic cancer have been described however, the prognostic significance of these genes in pancreatic cancer patients remains inconclusive. The aim of the present study was to evaluate the prognostic role of B7H1 and B7H4 in pancreatic cancer patients. Methods: Electronic databases (PubMed, EMBASE, and the Cochrane Library) were searched for relevant articles published before May 2019. Meta-analyses were performed by pooling the hazard ratios (HRs) between overall survival or cancer-specific survival and high or low expression of B7H1/B7H4 in pancreatic cancer patients. Subgroup and sensitivity analyses were performed, and sources of variabilities were explored by performing meta-regression. Results: Sixteen studies (1434 patients’ data) were included. Compared with low expression, high expression of B7H1 was associated with significantly poor overall survival (HR 1.92 (95% confidence interval (CI) 1.35, 2.74); P<0.001) and cancer-specific survival (HR 2.46 (95% CI 1.55, 3.90); P<0.001). High expression of B7H4 also predicted poor overall survival (HR 2.38 (95% CI 1.89, 3.00); P<0.001). In subgroup analyses, a significant association between B7H1 and overall survival was observed for trials conducted in China (HR 2.08 (95% CI 1.29, 3.34)) but not in Japan (HR 1.98 (95% CI 1.33, 2.96)); or in studies with <50% patients having high expression (HR 2.02 (95% CI 1.40, 2.91)) but not in studies with >50% patients with high expression (HR 1.40 (95% CI 0.87, 2.26)). Conclusion: The current study suggests that high B7H1 and B7H4 expression is associated with a poor prognosis in pancreatic cancer patients.

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Section: Discussionmentioning

confidence: 99%

The prognostic value of B7H1 and B7H4 expression in pancreatic cancer: A meta-analysis

Chen

et al. 2019

Int J Biol Markers

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“…B7-H4 protein is not detected in most healthy tissues but is widely expressed in various cancers. In some types of malignancies, it is associated with adverse clinical features and unfavorable prognoses [ 23 ]. Chen et al investigated B7-H4 protein in precancerous lesions of the esophagus and found it highly expressed in 9.1% of normal tissues, 40.7% of low-grade intraepithelial neoplasia, and 81.0% of high-grade intraepithelial neoplasia.…”

Section: Discussionmentioning

confidence: 99%

B7‐H4 Expression in Precancerous Lesions of the Uterine Cervix

Zhang

Zong

Zhang³

et al. 2021

BioMed Research International

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Over 10% of patients diagnosed with cervical intraepithelial neoplasia (CIN) have no lesions detected in their cervical conization specimens. The purpose of this study was to determine the factors related to the absence of such lesions. We particularly sought to investigate whether the expression of B7-H4 in precancerous lesions and cancer of the uterine cervix plays a role in the presence or absence of residual lesions in conization specimens and whether this protein is associated with T cells (i.e., Foxp3+ regulatory T cells, CD4+, and CD8+) and interferon-γ production. Of the 807 patients with CIN treated by conization, 104 (12.9%) had no lesions in their conization specimens. Seventy-five of these patients were deemed the study group and were matched with 75 patients who did have CIN detected in their conization specimens (the control group). Immunohistochemistry and immunofluorescence staining were used to detect B7-H4, Foxp3, CD4, CD8, and interferon-γ in the 75 pairs of specimens obtained via biopsy; 20 samples were found to have chronic cervicitis, and another 20 had squamous cell carcinoma of the cervix. Menopause, the absence of human papillomavirus, low-grade histological findings, and a diagnosis of CIN1 and CIN2 on biopsy correlated with a low probability of lesions on conization specimens. B7-H4 expression was detected in 11.1% of CIN2, 46.6% of CIN3, and 70% of cervical cancer samples, but not in tissues representing chronic cervicitis or CIN1. B7-H4 expression was associated with the presence of lesions on conization specimens, increased regulatory T cells, decreased CD8+ T cells, and lower interferon-γ production. These data suggest that close follow-up and thorough reevaluation should be considered for patients diagnosed with CIN2 who are negative for B7-H4 expression on biopsy before proceeding with cervical conization.

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“…Moreover, as the number of studies was limited at that time, they are based on results from mixed methods of estimating B7H4 expression (ELISA, IHC) and sources of B7H4 expression (tissue, homogenates, blood sera) [24]. Additionally, some included different methods of prognosis estimation, such as the odds ratio (OR), rate ratio (RR), and hazard ratio (HR), to conduct the meta-analysis [25]. Furthermore, most studies were focused on the overall survival (OS) parameter, and two studies also evaluated disease-free survival (DFS) [25,26].…”

Section: The Aim Of the Studymentioning

confidence: 99%

“…Additionally, some included different methods of prognosis estimation, such as the odds ratio (OR), rate ratio (RR), and hazard ratio (HR), to conduct the meta-analysis [25]. Furthermore, most studies were focused on the overall survival (OS) parameter, and two studies also evaluated disease-free survival (DFS) [25,26]. The diseasespecific survival (DSS), progression-free survival (PFS), and recurrence-free survival (RFS) parameters have not yet been evaluated in meta-analyses.…”

Section: The Aim Of the Studymentioning

confidence: 99%

Prognostic Value of B7H4 Expression in Patients with Solid Cancers: A Systematic Review and Meta-Analysis

Dawidowicz,

Kula,

Mielcarska

et al. 2024

IJMS

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V-set domain-containing T-cell activation inhibitor 1 (aliases VTCN1, B7H4) participates in tumour immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the B7H4 prognostic value in solid cancers. Three databases were searched for relevant articles. The main endpoints were overall survival (OS), disease-specific survival (DSS), progression-free survival (PFS), recurrence-free survival (RFS), and disease-free survival (DFS). Appropriate hazard ratios (HRs) were pooled. The R studio software (version 4.0.3) was used for data analysis. Thirty-one studies met the inclusion criteria. High expression of B7H4 was associated with worse OS (HR = 1.52, 95% CI: 1.37–1.68) but not with DSS (HR = 1.14, 95% CI: 0.49–2.63), RFS (HR = 1.77, 95% CI: 0.75–4.18), DFS (HR = 1.29, 95% CI: 0.8–2.09), or PFS (HR = 1.71, 95% CI: 0.91–3.2) in patients with solid cancers. High expression of B7H4 is associated with a poorer prognosis in patients with solid cancers. B7H4 is a promising prognostic biomarker and immunotherapeutic target for various solid cancers because of its activity in cancer immunity and tumourigenesis.

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B7-H4 as an independent prognostic indicator of cancer patients: a meta-analysis

Cited by 8 publications

References 53 publications

The prognostic value of B7H1 and B7H4 expression in pancreatic cancer: A meta-analysis

The prognostic value of B7H1 and B7H4 expression in pancreatic cancer: A meta-analysis

B7‐H4 Expression in Precancerous Lesions of the Uterine Cervix

Prognostic Value of B7H4 Expression in Patients with Solid Cancers: A Systematic Review and Meta-Analysis

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