BAALC-Expressing Earlier Leukemic Progenitors: Crucial Role in AML Relapses with Evaluation of Their Treatment and Prevention Efficacy

Abstract

A new concept of acute myeloid leukemia (AML) relapses is proposed which is linked with direct participation of BAALC-expressing earlier leukemic progenitors (ELP). The latter may be studied effectively by means of real-time quantitative polymerase chain reaction (RT-qPCR). Recent findings in support of this conception and ongoing prospective studies in the field are shortly discussed.