Babesia gibsoni: Field and laboratory studies of canine infections

Groves, Michael G.; Dennis, G L

doi:10.1016/0014-4894(72)90057-4

Cited by 63 publications

(48 citation statements)

References 3 publications

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“…This suggests the possibility that the thrombocytopenia in subclinical B. gibsoni infection is due to autoimmune responses, and the presence of anti-platelet IgG accelerates the platelet destruction in B. gibsoni infected dogs. Anemia is the most common symptom of infection with B. gibsoni [6,9,24], and is thought to be caused by mechanical destruction by the parasite, immunemediated intravascular or extravascular hemolysis, or immune-mediated extravascular hemolysis [2,3,16,17]. Oxidative damage may contribute to the destruction of erythrocytes by increasing their susceptibility to phagocytosis by macrophages [21].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Canine Babesia gibsoni Infection and Subclinical Infection among Tosa dogs in Aomori Prefecture, Japan

Matsuu

Kawabe

Koshida

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. To identify the incidence of Babesia gibsoni (B. gibsoni) in Aomori Prefecture, northeastern Japan, dogs with acute B. gibsoni infection were investigated at the Animal Teaching Hospital, Kitasato University, between April 2002 and March 2003. Eighteen dogs with acute B. gibsoni infection were recognized; they were all male dogs of the fighting dog breed Tosa. Their platelet counts were below normal and their packed cell volumes (PCVs) were at various levels. We collected blood samples from 141 Tosa dogs from Aomori Prefecture and used polymerase chain reaction assay to investigate the incidence of subclinical B. gibsoni infection. We also looked into the serological abnormalities associated with thrombocytopenia or anemia in subclinical infection. Forty-one of 87 dogs (47.1%) with histories of dog fighting, and one dog of 54 without a history of dog fighting were positive for B. gibsoni; that is, 42 of 141 dogs (29.8%) showed a positive result. The mean platelet counts of dogs with subclinical infection were significantly lower and levels of anti-platelet IgG were significantly higher than levels for dogs without infection. Anti-erythrocyte membrane IgG levels were significantly higher in dogs with subclinical infections, although mean PCVs were not significantly different. Tosa dogs from Aomori Prefecture, Japan, were highly infected with B. gibsoni subclinically and this pathogen might be successfully transmitted during dog fighting. Dogs with subclinical infections were at risk of chronic thrombocytopenia, which may be due to autoimmune mechanisms. KEY WORDS: anti-erythrocyte membrane IgG, anti-platelet IgG, Babesia gibsoni, Tosa dog.

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Section: Discussionmentioning

confidence: 99%

Incidence of Canine Babesia gibsoni Infection and Subclinical Infection among Tosa dogs in Aomori Prefecture, Japan

Matsuu

Kawabe

Koshida

et al. 2004

The Journal of Veterinary Medical Science

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“…Small babesiae cause diseases whose clinical manifestations in dogs are variable and mainly characterized by anemia (Groves and Dennis 1972). Other symptoms frequently found with varying strength include fever, lethargy, anorexia and spleenomegaly (Tiwari and Varshney 2002).…”

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confidence: 99%

Evidence of new pathogenic Theileria species in dogs

Dixit

Dixit²,

Varshney³

2010

J Parasit Dis

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Babesiosis, caused by tick-borne haematozoan organisms of the genus Babesia, is a parasitic disease of domestic and wild mammals. Canine Babesidae have historically been classified as ''large Babesia'' (Babesia canis) and ''small Babesia'' (Babesia gibsoni) based on the size of their intraerythrocytic forms. Recent publications, however, suggest that the diversity of piroplasm species infecting dogs might be greater than previously appreciated. Sequencing and phylogenetic analysis of the ssrRNA gene has revealed that canine piroplasms are found in three clades, 'true' Babesia sp. (B. canis and B. gibsoni), Theileria annae and Theileria-like group (B. conradae). This newly recognised piroplasm T. annae appears to be hyperendemic in northwest Spain. The vector for this emergent canine infection remains undescribed, although the Ixodes hexagonus is suspected based on their presence upon the dogs in NW Spain and the relative absence of others. These observations have introduced a major change in the approach to the epidemiology of babesiosis in dogs. More clinical samples and data will need to be collected and analyzed to understand the importance of Theileria species in dogs.

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“…These erythroid changes were also provided in the experimental infection of splenectomy cows with B. ovata and B. bigemina [7,27]. Although canine babesiosis with B. gibsoni develops progressive anemia in spite of low parasitemia, it shows the same type of pathogenesis or macrocytic anemia as bovine babesiosis [9].…”

mentioning

confidence: 99%

Susceptibility of Chinese Hamsters (Cricetulus griseus) to the Infection of Babesia microti

Ike

Murakami

Komatsu

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. Chinese hamsters were examined for the susceptibility to the infection with Babesia microti based on the hematological parameters during the course of infection. A marked decease in the RBC count, Ht value, Hb concentration, and an increase in WBC count due to the development of neutrophils or monocytes were recognized with the progress of parasitemia. Remarkable clinical findings were anemia and persistent infection with a low level of parasite burden in the chronic and convalescent stages. From these findings, it was concluded that Chinese hamsters were susceptible to infection with B. microti and would be useful for infection examination with the parasite. KEY WORDS: Babesia microti, Chinese hamster, susceptibility.

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Babesia gibsoni: Field and laboratory studies of canine infections

Cited by 63 publications

References 3 publications

Incidence of Canine Babesia gibsoni Infection and Subclinical Infection among Tosa dogs in Aomori Prefecture, Japan

Incidence of Canine Babesia gibsoni Infection and Subclinical Infection among Tosa dogs in Aomori Prefecture, Japan

Evidence of new pathogenic Theileria species in dogs

Susceptibility of Chinese Hamsters (Cricetulus griseus) to the Infection of Babesia microti

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