Babesiosis Associated Myocarditis

Kandalaft, Osama; Craig, Calvin; Pervaiz, Abdullah; Hiser, William

doi:10.1016/s0735-1097(19)33093-1

Cited by 4 publications

(3 citation statements)

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“…In a paper by Kandalaft et al, an 83-yearold immunocompetent male (again with coronary artery disease) was diagnosed with myocarditis due to a massive parasite load. The authors recommended transfusion when parasite loads exceed 10% to remove infected red blood cells from circulation [21].…”

Section: Cardiacmentioning

confidence: 99%

Babesiosis: Appreciating the Pathophysiology and Diverse Sequela of the Infection

Ortíz¹,

Millhouse²,

Cox³

et al. 2020

Cureus

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Babesiosis is a blood-borne disease found mainly in the United States caused by a parasitic piroplasm. While most infections are mild to moderate in immunocompetent hosts, life-threatening complications can occur in those with significant comorbidities like congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD). There is sparse literature discussing the complications of Babesia microti infection or the pathophysiology and management thereof. A literature review was conducted to consolidate the current knowledge about the disease, pathophysiology, and proposed management of all potential complications based on risk factors and other clinical information. A MeSH cross-references strategy was employed in PubMed using the search terms "babesia" and "babesiosis" and the established associated conditions, and the search expanded to increase capture. Only papers written in the English language and discussing human subjects in the North American patient population were included. The initial search yielded 315 papers and, after applying the inclusion/exclusion criteria, a final number of 18 was reviewed. The various complications and pathophysiology thereof are then discussed according to organ system. Babesia is a subversive parasite associated with a variety of conditions. We hope a better appreciation of all potential presentations and complications will help clinicians manage this increasingly common zoonosis and reduce adverse effects. More research is recommended into the pathophysiology and prevention of complications following this and other tick-borne illnesses.

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Section: Cardiacmentioning

confidence: 99%

Babesiosis: Appreciating the Pathophysiology and Diverse Sequela of the Infection

Ortíz¹,

Millhouse²,

Cox³

et al. 2020

Cureus

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show abstract

“…Up to 10% of individuals presenting with babesiosis have evidence of decompensated heart failure, presumably due to anemia [ 129 ]. Babesiosis-associated myocarditis has also been described [ 130 ].…”

Section: Vector-borne Diseasementioning

confidence: 99%

Climate change and the prevention of cardiovascular disease

Jacobsen

Khiew²,

Duffy³

et al. 2022

American Journal of Preventive Cardiology

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“…Babesia infection in humans can cause haemolytic anaemia and develop clinical symptoms, such as fever, sweating, and muscle pain; multiple organ diseases, such as hepatosplenomegaly [ 6 ], acute nephritis [ 7 ], and myocarditis [ 8 ]; and acute respiratory distress syndrome, disseminated intravascular coagulation, heart failure, and even death in severe cases depending on the immunocompetence of the infected individual [ 9 – 11 ]. Infection with Babesia can quickly activate the immune defense system to fight it, and some infected patients can recover without specific therapeutic intervention [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function

et al. 2022

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Background Babesia is a common protozoan parasite that infects red blood cells. In mice infected with Babesia microti, the red blood cells were lysed, resulting in decreased oxygen-carrying capacity. To compensate for low blood oxygen levels, stress on the heart was greatly increased. Babesiosis induces a variety of pathologies; meanwhile, heart tissues initiate self-repair responses to babesiosis-induced tissue damage to restore heart function. Methods To discover the molecular mechanisms of the damage and self-repair in the heart after B. microti infection in mice, we investigated the changes in protein expression and phosphorylation modification levels in heart tissues at 0, 5, 8, 11, and 19 days post-infection using data-independent acquisition (DIA) quantitative proteomics. Results The numbers of global proteins we identified were 1934, 1966, 1984, 1989, and 1955 and of phosphopeptides were 5118, 5133, 5130, 5133, and 5140 at 0, 5, 8, 11, and 19 days, respectively, in heart cells after infection with B. microti. The results showed that after B. microti infection the differentially expressed proteins in mice mainly include fibrinogen α (Fgα), fibrinogen β (Fgβ), Serpina1b, Serpina1c, cathepsin Z, cytochrome c oxidases (COXs), RPS11, and RPS20. The proteins with phosphorylation changes mainly include 20-kDa light chain of myosin II (MLC20), myosin light chain kinase (MLCK), mitogen-activated protein kinase 14 (MAPK14), and Akt1. These proteins were mainly involved in coagulation processes, cell apoptosis, oxidative phosphorylation, and ribosomes. Conclusions The coagulation cascade-related proteins, apoptosis-related proteins, oxidative phosphorylation-related proteins, and other types of proteins are all involved in the damage and self-repair process in the heart after B. microti infection. These results offer a wealth of new targets for further exploration into the causes of heart disease induced by Babesia infection and are of great significance for novel drug development and new opportunities for targeted therapies. Graphical Abstract

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Babesiosis Associated Myocarditis

Cited by 4 publications

References 0 publications

Babesiosis: Appreciating the Pathophysiology and Diverse Sequela of the Infection

Babesiosis: Appreciating the Pathophysiology and Diverse Sequela of the Infection

Climate change and the prevention of cardiovascular disease

Phosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function

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