Babesiosis in a Massachusetts Resident

Western, Karl A.; Benson, Gordon D.; Gleason, Neva N.; Healy, George R.; Schultz, Myron G.

doi:10.1056/nejm197010152831607

Cited by 176 publications

(81 citation statements)

References 6 publications

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“…As described above in this review's introduction, historical evidence suggests that B. microti initially became established on offshore islands of New England (22,106,124) and then moved to neighboring coastal communities of Connecticut, Massachusetts, New York, and Rhode Island (38,56,129). The EU-1 parasite, which was responsible for the first cases of human babesiosis in Italy and Austria and a subsequent case in Germany, has been described as a distinct agent that is closely related to B. divergens (44,47).…”

Section: Geographic Distributionmentioning

confidence: 93%

“…The initial U.S. case of human babesiosis was reported from California in 1966, although the species of Babesia implicated in this case was never definitively identified (108). Within 3 years (1969), the first documented human infection attributed to Babesia microti was reported on Nantucket Island, MA (124). From its initial description on an offshore island of New England, the geographic range where infections with B. microti have been reported has expanded to include coastal communities in Connecticut, Massachusetts, New York, and Rhode Island, eventually spreading to the interior of New England (3,22,67,87,105).…”

Section: Introductionmentioning

confidence: 97%

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Transfusion-TransmittedBabesiaspp.: Bull's-Eye onBabesia microti

2011

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SUMMARY Babesia spp. are intraerythrocytic protozoan parasites of animals and humans that cause babesiosis, a zoonotic disease transmitted primarily by tick vectors. Although a variety of species or types of Babesia have been described in the literature as causing infection in humans, the rodent parasite Babesia microti has emerged as the focal point of human disease, especially in the United States. Not only has B. microti become established as a public health concern, this agent is increasingly being transmitted by blood transfusion: estimates suggest that between 70 and 100 cases of transfusion-transmitted Babesia (TTB) have occurred over the last 30 years. A recent upsurge in TTB cases attributable to B. microti , coupled with at least 12 fatalities in transfusion recipients diagnosed with babesiosis, has elevated TTB to a key policy issue in transfusion medicine. Despite clarity on a need to mitigate transmission risk, few options are currently available to prevent the transmission of B. microti by blood transfusion. Future mitigation efforts may stress serological screening of blood donors in regionalized areas of endemicity, with adjunct nucleic acid testing during the summer months, when acute infections are prevalent. However, several hurdles remain, including the absence of a licensed blood screening assay and a thorough cost-benefit analysis of proposed interventions. Despite current obstacles, continued discussion of TTB without proactive intervention is no longer a viable alternative.

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Section: Geographic Distributionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Transfusion-TransmittedBabesiaspp.: Bull's-Eye onBabesia microti

2011

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“…The beggining of knowledge on human babesiosis was dramatic, since three of four cases occurred in splenectomized patients followed by death. The first case of babesiosis in a healthy person, with intact spleen, was reported in 1969 in a woman from Nantucket Island (Massachusetts, USA) (Wester et al 1970), hospitalized with fever, headache and abdominal pain. Blood smear analysis revealed numerous ring-like structures suggesting Plasmodium falciparum infection, and the patient was treated with cloroquine.…”

mentioning

confidence: 99%

Coexistence of antibodies to tick-borne agents of babesiosis and Lyme borreliosis in patients from Cotia county, State of São Paulo, Brazil

Yoshinari

Abrão

Bonoldi

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…First case of babesiosis was reported in Croatia in 1957 [2]. Babesiosis caused by the B. microti in human in United States was first documented in 1969 [3].…”

Section: Introductionmentioning

confidence: 99%

Structural analysis of the Babesia microti thioredoxin reductase: a potential drug target for babesiosis treatment

Arora¹,

Banerjee²,

Narasu³

2018

biomedicalresearch

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Babesia microti, the causative agent of human babesiosis which was endemic in United States and parts of Europe with sporadic cases in other regions is expanding its geographical range. Being a common transfusion threat, Babesia has become a cause of concern in researchers and epidemiologists. Human babesiosis is now recognized as an emerging disease and gains more attention now than ever before. Thioredoxin reductase, a promising drug target in apicomplexan parasite has been validated in several species. This study focused on in-silico analysis of physicochemical properties, functional and structural aspects of thioredoxin reductase of B. microti. Comparative modeling approach was adopted for developing the three dimensional structural model of Thioredoxin reductase of Babesia microti. The model developed was found to be of reasonably good stereo-chemical quality by structure validation servers. This study will provide valuable insights about the function and structure of the enzyme thioredoxin reductase of B. microti and aid in developing effective chemotherapeutic agents for control and treatment of Babesia.

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Babesiosis in a Massachusetts Resident

Cited by 176 publications

References 6 publications

Transfusion-TransmittedBabesiaspp.: Bull's-Eye onBabesia microti

Transfusion-TransmittedBabesiaspp.: Bull's-Eye onBabesia microti

Coexistence of antibodies to tick-borne agents of babesiosis and Lyme borreliosis in patients from Cotia county, State of São Paulo, Brazil

Structural analysis of the Babesia microti thioredoxin reductase: a potential drug target for babesiosis treatment

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