Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses

Wolf, Ronni; Tüzün, Yalçın

doi:10.1016/j.clindermatol.2015.04.008

Cited by 23 publications

(16 citation statements)

References 21 publications

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“…Nine out of 12 patients had tinea cruris as their primary dermatoses. This can eluded to by the possible hypothesis of mechanical occlusion and increased drug delivery in eccrine rich areas 8 . Fungal culture positivity was seen in only seven out of 12 patients (58%) consistent with other studies showing 60% to 70% positivity 14 .…”

Section: Discussionsupporting

confidence: 83%

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Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India

Hassanandani

Panda

Agarwal

et al. 2020

Dermatologic Therapy

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SDRIFE (symmetrical drug related intertriginous and flexural exanthem) is a benign self-limiting adverse drug reaction (ADR) primarily affecting the intertriginous, gluteal and flexural regions symmetrically in the absence of systemic involvement. It is considered to be a variant of baboon syndrome. Pathogenesis is poorly understood but is thought to be result of a delayed hypersensitivity response after exposure to the drug. Commonly implicated drugs are beta-lactam antibiotics. With the rising incidence of dermatophytosis in the Indian subcontinent, the use of oral anti fungals has become rampant. SDRIFE due to itraconazole has been rarely reported in literature. We hereby present a series of 12 patients presenting with SDRIFE due to itraconazole, which is by far the largest reported in existing literature. This case series highlights the importance of identifying these cutaneous adverse drug reactions in a setting where itraconazole is commonly being used.

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Section: Discussionsupporting

confidence: 83%

“…Both the above theories is supported by the fact that in patients receiving chemotherapy, localized histopathological changes in form of eccrine squamous syringometaplasia is seen. This is due to secretion of the chemotherapeutic drug into eccrine ducts and is also responsible for a condition known as toxic erythema of chemotherapy 8 …”

Section: Discussionmentioning

confidence: 99%

Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India

Hassanandani

Panda

Agarwal

et al. 2020

Dermatologic Therapy

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“…The proposed diagnostic criteria include exposure to a systemic medication, symmetric well‐demarcated erythema of the gluteal/inguinal region and at least one other intertriginous or flexural region, and lack of systemic toxicity . It can present as flexural dermatitis, maculopapular rash, and vasculitis‐like lesions, which was seen in our patient . Infections must be ruled out as well.…”

Section: Discussionmentioning

confidence: 89%

“…Biopsy for histopathology from the pustular lesion showed spongiotic epidermis, and occasional necrotic keratinocytes overlying a dermis showing perivascular lymphohistiocytic infiltrates with extravasated red blood cells, which is consistent with SDRIFE ( Figure S1A which was seen in our patient. 2 Infections must be ruled out as well. The histopathological findings are also nonspecific, as in our case.…”

Section: Case Reportmentioning

confidence: 99%

A rare case of clozapine‐induced symmetrical drug‐related intertriginous and flexural exanthema with vasculitis‐like lesions

et al. 2020

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K E Y W O R D S : baboon syndrome, clozapine, drug patch testing, drug reaction, SDRIFE, systematized contact dermatitis, vasculitis Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)is a benign drug reaction that is diagnosed clinically. We report a unique case of SDRIFE secondary to clozapine, confirmed by patch testing. CASE REPORTAn 18-year-old man presented with high fever and pruritic red eruptions and pustules for 3 days. The rash appeared progressively on the axillae, legs, groin, and back over 2 days. About 2 weeks before, he had been started on lithium and clozapine due to mania. On examination, confluent erythematous papules, coalescing to form larger plaques, studded with pinhead-sized pustules, were present in the aforementioned sites. In addition, discrete purpuric papules over the dorsum of the feet and shins were noted (Figure 1). Mucosae were not involved. An infectious exanthematous rash or lithium-induced acute generalized exanthematous pustulosis (AGEP)/SDRIFE was considered as differential diagnosis.Workup for acute febrile illness was unyielding. Gram stain from the pustules showed scant neutrophils with no evidence of bacteria.Biopsy for histopathology from the pustular lesion showed spongiotic epidermis, and occasional necrotic keratinocytes overlying a dermis showing perivascular lymphohistiocytic infiltrates with extravasated red blood cells, which is consistent with SDRIFE ( Figure S1A,B); and 318 SUVARNA ET AL.

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“…Andersen and his coauthors presented three patients who had developed generalized erythematous maculopapular rash located in glutea and intertriginous areas, provoked by to mercury, nickel and ampicillin. They named the eruption as BS cause of lesional presentation of the patient's buttocks like to the red appeareance of a baboon [4]. As we can see from reported cases in the literature BS mostly presented 18 months of age to 84 years old patients, it can be seen at any age and both sexes.…”

Section: Discussionmentioning

confidence: 95%

A case report of Baboon Syndrome due to azithromycin

Daye¹

2019

Our Dermatol Online

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Baboon syndrome is a type IV delayed hypersensitivity reaction and characterized by asymptomatic erythematous maculopapular rash due to drugs. The rash typically involves flexural areas, gluteal and perineal regions. This eruption, may occur within hours to days of exposure to suspecting drug and resolves rapidly by discontinuation of the triggering drug. We present a 76-years-old male patient who admitted to our clinic with symettrical, erythematous eruption and was diagnosed Baboon syndrome by clinical and histopathological findings. The eruption disappeared in 1 week after appropriate treatment via intravenous methyl prednisolone, oral antihistamines and topical steroids.

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Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses

Cited by 23 publications

References 21 publications

Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India

Rising trends of symmetrical drug related intertriginous and flexural exanthem due to Itraconazole in patients with superficial dermatophytosis: A case series of 12 patients from eastern part of India

A rare case of clozapine‐induced symmetrical drug‐related intertriginous and flexural exanthema with vasculitis‐like lesions

A case report of Baboon Syndrome due to azithromycin

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