This study investigates how a first-time Cypriot mother used music in caring for her infant during the COVID-19 pandemic. Limited research has been done about musical parenting during this time, highlighting the importance of this single case study. For 5 months, the mother-participant engaged in an online musical parenting program, which aimed to increase knowledge regarding the use of music and movement with infants and suggest ways for practical implications. Data included interviews, informal discussions, the participant’s digital journals and filmed videos, and researcher field notes taken during the teaching program. Thematic analysis revealed that even without prior formal or informal musical training, and in prolonged isolation with related stressors during the COVID-19 pandemic, the mother-participant engaged extensively in musical interaction with her infant. Musical activities provided a meaningful framework for the mother to cope with the daily demands of mothering and to manage the isolation due to COVID-19. Music engagement enhanced the bond between the mother and her infant, united family members, and promoted her perceived state of well-being. The findings support previous research on the significance of musical interaction between caregivers and infants, particularly during the COVID-19 outbreak.