2021
DOI: 10.21203/rs.3.rs-396650/v1
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BACE Inhibitor Treatment in Mice Induces Hyperactivity in a Seizure-Related Gene 6 Family Protein Dependent Manner but Does Not alter Spatial Learning and Reference Memory

Abstract: BackgroundBACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms and, in some cases, have led to increased adverse events, cognitive worsening and hippocampal atrophy. A potential drawback of this strategy is the effect of BACE inhibition on other BACE1 substrates such as Seizure-related gene 6 (Sez6) family proteins which… Show more

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