Bachmann’s Bundle

Campenhout, Margo J.H. van; Yaksh, Ameeta; Kik, Charles; Jaegere, Peter P. de; Ho, Siew Yen; Allessie, Maurits A.; Groot, Natasja M.S. de

doi:10.1161/circep.113.000758

Cited by 82 publications

(37 citation statements)

References 63 publications

(70 reference statements)

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“…The histological study of Becker et al demonstrated in fact that structural continuity of Bachmann's bundle is often compromised, especially in patients with AF [19]. Conduction disorders at Bachmann's bundle have been proposed to be a measure of more general atrial electrical pathology [20]. However, we found that conduction disturbances in other areas during sinus rhythm are not related to AF.…”

Section: Atrial Fibrillation and Conduction Disorders During Sinus Rhcontrasting

confidence: 48%

The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm

Does

Lanters

Teuwen

et al. 2019

J. of Cardiovasc. Trans. Res.

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Different arrhythmogenic substrates for atrial fibrillation (AF) may underlie aortic valve (AV) and mitral valve (MV) disease. We located conduction disorders during sinus rhythm by high-resolution epicardial mapping in patients undergoing AV (n = 85) or MV (n = 54) surgery. Extent and distribution of conduction delay (CD) and block (CD) across the entire right and left atrial surface was determined from circa 1880 unipolar electrogram recordings per patient. CD and CB were most pronounced at the superior intercaval area (2.5% of surface, maximal degree 6.6%/cm 2). MV patients had a higher maximal degree of CD at the lateral left atrium than AV patients (4.2 vs 2.3%/cm 2 , p = 0.001). A history of AF was most strongly correlated to CD/CB at Bachmann's bundle and age. Although MV patients have more conduction disorders at the lateral left atrium, disturbed conduction at Bachmann's bundle during sinus rhythm indicates the presence of atrial remodeling which is related to AF episodes.

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Section: Atrial Fibrillation and Conduction Disorders During Sinus Rhcontrasting

confidence: 48%

The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm

Does

Lanters

Teuwen

et al. 2019

J. of Cardiovasc. Trans. Res.

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“…Bachmann’s bundle is considered to be the most important pathway for inter-atrial conduction, and disruption of Bachmann’s bundle (“advanced inter-atrial block”) in animals has been shown to cause prolongation of the P wave and specific alterations in P wave morphology (P wave prolongation with biphasic P waves in the inferior leads). [39] Disruption of posterior interatrial fibers is felt to cause partial inter-atrial block, leading to P wave prolongation alone (with or without increased PTFV 1 ). [40] As mentioned previously, the pattern of electrocardiographic left atrial abnormality (and thus also of abnormal PTFV 1 or P prime deep terminal negativity) is more indicative of interatrial conduction disease than of anatomic or hemodynamic features of the left atrium.…”

Section: The P Wave Indicesmentioning

confidence: 99%

Atrial Fibrillation Predictors: Importance of the Electrocardiogram

German

Kabir

Dewland

et al. 2015

Ann Noninvasive Electrocardiol

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Atrial fibrillation (AF) is the most common arrhythmia in adults and is associated with significant morbidity and mortality. Substantial interest has developed in the primary prevention of AF, and thus the identification of individuals at risk for developing AF. The electrocardiogram (ECG) provides a wealth of information which is of value in predicting incident AF. The PR interval and P wave indices (including P wave duration, P wave terminal force, P wave axis, and other measures of P wave morphology) are discussed with regard to their ability to predict and characterize AF risk in the general population. The predictive value of the QT interval, ECG criteria for left ventricular hypertrophy, and findings of atrial and ventricular ectopy are also discussed. Efforts are underway to develop models which predict AF incidence in the general population, however, at present little information from the ECG is included in these models. The ECG provides a great deal of information on AF risk and has the potential to contribute substantially to AF risk estimation, but more research is needed.

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“…[11][12][13] It was therefore assumed that conduction disorders within BB play a major role in the pathophysiology of AF, although the exact mechanism is not understood. 11,14,15 To date, conduction properties of BB in humans have never been investigated in detail. In this study, we therefore performed direct high-resolution mapping of BB during sinus rhythm (SR) in patients undergoing coronary artery bypass surgery to examine (1) whether conduction disorders are present at BB, (2) the extensiveness of conduction disorders and their impact on LA excitation, and (3) differences in characteristics of conduction disorders between patients with and without AF episodes.…”

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confidence: 99%

Relevance of Conduction Disorders in Bachmann’s Bundle During Sinus Rhythm in Humans

Teuwen

Yaksh

Lanters

et al. 2016

Circ: Arrhythmia and Electrophysiology

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Background-Bachmann's bundle (BB) is considered to be the main route of interatrial conduction and to play a role in development of atrial fibrillation (AF). The goals of this study are to characterize the presence of conduction disorders in BB during sinus rhythm and to study their relation with AF. Methods and Results-High-resolution epicardial mapping (192 unipolar electrodes, interelectrode distance: 2 mm) of sinus rhythm was performed in 185 patients during coronary artery bypass surgery of whom 13 had a history of paroxysmal AF. Continuous rhythm monitoring was used to detect postoperative AF during the first 5 postoperative days. In 67% of the patients, BB was activated from right to left; in the remaining patients from right and middle (21%), right, central, and left (8%), or central (4%) site. Mean effective conduction velocity was 89 cm/s. Conduction block was present in most patients (75%; median 1.1%, range 0-12.8) and was higher in patients with paroxysmal AF compared with patients without a history of AF (3.2% versus 0.9%; P=0.03). A high amount of conduction block (>4%) was associated with de novo postoperative AF (P=0.02). Longitudinal lines of conduction block >10 mm were also associated with postoperative AF (P=0.04). Conclusions-BB may be activated through multiple directions, but the predominant route of conduction is from right to left. Conduction velocity across BB is around 90 cm/s. Conduction is blocked in both longitudinal and transverse direction in the majority of patients. Conduction disorders, particularly long lines of longitudinal conduction block, are more pronounced in patients with AF episodes. (Circ Arrhythm Electrophysiol. 2016;9:e003972.

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Bachmann’s Bundle

Cited by 82 publications

References 63 publications

The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm

The Effects of Valvular Heart Disease on Atrial Conduction During Sinus Rhythm

Atrial Fibrillation Predictors: Importance of the Electrocardiogram

Relevance of Conduction Disorders in Bachmann’s Bundle During Sinus Rhythm in Humans

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