Bacillary Angiomatosis Associated With Pseudoepitheliomatous Hyperplasia

Amsbaugh, Sean; Huiras, Erin E.; Wang, Nadia S; Wever, Aaron; Warren, Simon

doi:10.1097/01.dad.0000154396.14971.aa

Cited by 27 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A rare association between pseudoepitheliomatous hyperplasia and Bartonella infection has been reported in the medical literature. 11 This diagnosis was considered in the differential, but the pattern of infiltration by atypical squamous cells into the deeper stromal tissue confirmed that the underlying disease process was a malignancy and not reactive hyperplasia alone. Finally, it has also been demonstrated that Bartonella spp stimulate cellular proliferation and may lead to tumor formation.…”

Section: Discussionmentioning

confidence: 93%

Concomitant cat scratch disease and squamous cell carcinoma in a cardiac transplant

et al. 2012

View full text Add to dashboard Cite

Cat scratch disease has been reported very rarely in cardiac transplant recipients. In a review of 1073 episodes of infection in 620 heart transplant patients over a 16 year period, only one case of infection secondary to Bartonella henselae was documented. Another case of hepatosplenic bacillary angiomatosis from B. henselae was reported 2 decades ago in a heart transplant recipient who had presented with fevers of unknown origin. Although the typical clinical manifestation is that of a skin lesion accompanied with lymphadenopathy, cat scratch disease may present with persistent fevers without a clinically overt infective focus in immunosuppressed individuals. Moreover, more than one disease process may coexist in immunocompromised hosts. While the lymphadenopathy in our patient was secondary to Cat scratch disease, interestingly, the adjacent skin lesion that was thought to represent unhealed site of inoculation of Bartonella was diagnosed as squamous cell carcinoma.

show abstract

Section: Discussionmentioning

confidence: 93%

Concomitant cat scratch disease and squamous cell carcinoma in a cardiac transplant

et al. 2012

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4]7,8] Culture of biopsied tissues, electron microscopy (EM) examination, polymerase chain reaction, and serology are other procedures that can be used for BA diagnosis. [1,3,4,8,9] In particular, EM has been useful for confirming the identity of bacilli when staining techniques have been nondiagnostic. [9] The basic histological architecture of BA is a lobular proliferation of endothelium-lined blood vessels within the superficial dermis.…”

Section: Discussionmentioning

confidence: 99%

“…[1,3,4,8,9] In particular, EM has been useful for confirming the identity of bacilli when staining techniques have been nondiagnostic. [9] The basic histological architecture of BA is a lobular proliferation of endothelium-lined blood vessels within the superficial dermis. Numerous perivascular neutrophilic granulocytes, especially in deeper regions, are also typically present, together with diffuse formation of blood capillaries ("infectious angiogenesis").…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A case of bacillary angiomatosis developed at a burn site

Albayrak

Ünal

et al. 2012

Indian J Dermatol Venereol Leprol

View full text Add to dashboard Cite

Bacillary Angiomatosis (BA) is frequently seen in patients with human immunodeficiency virus (HIV)-induced immunodeficiency. Our patient was a case that developed granuloma-like lesions in the area of a burn, 8 days after being burnt on the upper right arm by scalding water. No indication of immune deficiency was observed and no history of direct contact with cats was evident. By the sixth day of the patient's admission to our clinic, some of the lesions had reached a diameter of 2.5 cm. An excision biopsy was carried out from the lesions present on the patient. Electron microscopy revealed solitary bacilli located close to the capillary wall. Oral erythromycin treatment was implemented at 250 mg, 4 times a day for 2.5 months. Within this period of treatment, the lesions regressed completely, and a complete cure was achieved. This case demonstrates that BA must be considered in the differential diagnosis of both HIV-infected and immunocompetent patients.

show abstract

“…In addition to a vaguely lobulated intradermal proliferation of capillaries lined by plump, epithelioid endothelial cells, there are aggregates of polymorphonuclear leucocytes, with karyorrhectic debris and amphophilic extracellular aggregates of bacillary organisms in the intervening stroma 4 104 105. Rarely, BA is associated with pseudoepitheliomatous hyperplasia 106. WS staining will highlight the clumps of Bartonella organisms.…”

Section: Diagnostic Approachmentioning

confidence: 99%

The HIV-positive skin biopsy

Grayson¹

2007

J Clin Pathol

View full text Add to dashboard Cite

Dermatological disorders are a frequent presenting feature of HIV infection and/or AIDS. More than 90% of HIV-infected patients will suffer from one or more skin diseases during the course of their illness. This trend is reflected in the increasing number of skin biopsies from HIV-positive patients in those parts of the world where HIV infection/AIDS is highly prevalent. Histopathologists are therefore required to possess a working knowledge of the broad spectrum of cutaneous manifestations of HIV infection. These include the range of dermatoses that are specific to HIV infection, the more common dermatoses occurring with greater frequency (or modified by) HIV infection/AIDS, the spectrum of infectious diseases (often opportunistic) caused by viruses, bacteria, fungi, protozoa and even arthropods, and neoplastic conditions such as Kaposi sarcoma and B-cell non-Hodgkin lymphoma. The risk for adverse skin reactions to certain drugs is also greatly increased. Although the introduction of highly active antiretroviral therapy has resulted in a dramatic decrease in opportunistic infections, several of these drugs may result in adverse reactions in the skin. Skin biopsies play a vital diagnostic role when different diseases present with clinically similar skin lesions. Biopsy material should always be examined carefully to exclude dual pathology. The diagnosis may need to be confirmed with histochemical and immunohistochemical stains, and/or molecular studies. Where indicated, additional biopsies for microbiological culture should always be recommended. The examination of multiple serial sections often proves invaluable. A diagnostic approach is given based on the predominant histological reaction pattern, with an emphasis on clinicopathological correlation.

show abstract

Bacillary Angiomatosis Associated With Pseudoepitheliomatous Hyperplasia

Cited by 27 publications

References 22 publications

Concomitant cat scratch disease and squamous cell carcinoma in a cardiac transplant

Concomitant cat scratch disease and squamous cell carcinoma in a cardiac transplant

A case of bacillary angiomatosis developed at a burn site

The HIV-positive skin biopsy

Contact Info

Product

Resources

About