Bacillary Angiomatosis in an Immunocompetent Patient

Agrawal, Shruti; Singal, Archana; Arora, Vinod

doi:10.4103/idoj.idoj_524_21

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…Up to November 15th, 2023, 24 cases of cBA are reported in not severely immunocompromised hosts [ 8 , 11 , 14 – 22 , 26 – 36 ]. In one case antibiotic treatment was not prescribed [ 31 ] and in another case therapy was not reported [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…The complex and not completely understood interactions between host T-cell responses and Bartonella spp. virulence factors mentioned above lead to the red to violaceous lesions which are clinically seen even in not severely immunocompromised patients with cBA and the typical granulomatous and angioproliferative lesions of cBA which can be observed on microscopic examination [ 8 , 11 , 14 – 22 , 26 – 33 , 36 ]. In such cases, diagnosis could be very tricky for several reasons.…”

Section: Discussionmentioning

confidence: 99%

“…Second, cBA lesions can be mistaken for similar ones due to both infective (e.g., Mycobacterium spp., Nocardia spp., Sporothrix spp., Histoplasma spp.) or other (e.g., neoplasm, trauma) causes [ 8 , 11 , 14 , 15 ]. Third, Bartonella spp.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, among the cases we identified, it was performed only in three patients to diagnose cBA [ 8 , 22 ]. For all these reasons, cBA could be underdiagnosed [ 3 , 14 ] thus it is likely that its prevalence is underestimated, although an increase in incidence should be expected in the next years [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

“…Only for the latter cathegory treatment guidelines are available, issued by the National Institute of Health (NIH) that recommends using doxycycline or erythromycin for at least three months [ 24 ]. However, cBA in patients not suffering from major immunocompromising conditions is considered rare [ 14 ] and there is no consensus about treatment, since no studies enrolled enough of these patients to validate type and duration of antimicrobic treatment. Therefore, we focused on patients not suffering from immunocompromising conditions and reviewed current literature to provide insights about antibiotic treatment and its duration.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment

Rotundo,

Tassone,

Marascio

et al. 2024

BMC Infect Dis

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Background Cutaneous bacillary angiomatosis (cBA) is a vascular proliferative disorder due to Bartonella spp. that mostly affects people living with HIV (PLWH), transplanted patients and those taking immunosuppressive drugs. Since cBA is mostly related to these major immunocompromising conditions (i.e., T-cell count impairment), it is considered rare in relatively immunocompetent patients and could be underdiagnosed in them. Moreover, antimicrobial treatment in this population has not been previously investigated. Methods We searched the databases PubMed, Google Scholar, Scopus, OpenAIRE and ScienceDirect by screening articles whose title included the keywords “bacillary” AND “angiomatosis” and included case reports about patients not suffering from major immunocompromising conditions to provide insights about antibiotic treatments and their duration. Results Twenty-two cases of cBA not related to major immunocompromising conditions were retrieved. Antibiotic treatment duration was shorter in patients with single cBA lesion than in patients with multiple lesions, including in most cases macrolides and tetracyclines. Conclusions cBA is an emerging manifestation of Bartonella spp. infection in people not suffering from major immunocompromising conditions. Until evidence-based guidelines are available, molecular tests together with severity and extension of the disease can be useful to personalize the type of treatment and its duration.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment

Rotundo,

Tassone,

Marascio

et al. 2024

BMC Infect Dis

View full text Add to dashboard Cite

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An autochthonous case of cutaneous bacillary angiomatosis not related to major immunosuppression: An emerging or overlooked disease?

Rotundo,

Bono,

Mazzitelli

et al. 2024

International Journal of Infectious Diseases

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Bacillary Angiomatosis in a Patient With HIV and Disseminated Mycobacterium avium Complex Infection

Caceres,

Ruml,

Montejano

et al. 2024

Cureus

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Bartonella is a genus of arthropod-borne bacterial pathogens that typically cause persistent infections of erythrocytes and endothelial cells in mammalian hosts. The species that primarily infect humans are Bartonella henselae and Bartonella quintana. Depending on immune status, the clinical presentation of B. henselae may differ, manifesting as cat-scratch disease in immunocompetent individuals or bacillary angiomatosis (BA) and peliosis in immunocompromised patients. The cutaneous manifestations of BA are typically characterized by occasionally painful, angiomatous papules and nodules, often with a chronic, persistent course. Herein, we present a case of biopsy-confirmed B. henselae infection in a 32-year-old HIV-positive female with acquired immunodeficiency syndrome in the setting of disseminated Mycobacterium avium complex infection, an association that has been less frequently described. This case serves as an important reminder to consider uncommon opportunistic infectious etiologies when examining immunocompromised patients, as prompt diagnosis and treatment are essential in this patient population.

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Bacillary Angiomatosis in an Immunocompetent Patient

Cited by 3 publications

References 9 publications

A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment

A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment

An autochthonous case of cutaneous bacillary angiomatosis not related to major immunosuppression: An emerging or overlooked disease?

Bacillary Angiomatosis in a Patient With HIV and Disseminated Mycobacterium avium Complex Infection

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