Bacillary Layer Detachment in Neovascular Age-Related Macular Degeneration: Case Series

Abstract

Purpose: This study seeks to report the clinical and multimodal imaging findings of eight eyes of seven patients with neovascular age-related macular degeneration (nAMD) who developed bacillary layer detachment (BALAD). Setting/Venue: The patients were analysed at the Western Eye Hospital in London, UK. Methods: The approaches of this research include clinical examinations and multimodal imaging-based description of cases of nAMD with BALAD. Results: We report multimodal imaging findings of bacillary layer detachment (BALAD) in patients with nAMD. Conclusions: A bacillary layer detachment was detected in patients with neovascular age-related macular degeneration. This multimodal imaging finding is not commonly described in the literature for this disease.

Bacillary layer setachment (BALAD) in neovascular age-related macular degeneration — three years’ follow-up of a case study

“…These findings align with results from other similar studies [2,5,8]. While recent reports discussing nAMD with BALAD are limited, existing literature indicates that, in almost all cases, ranibizumab, aflibercept, or bevacizumab rapidly resolved BALAD and significantly improved vision in most patients [2,5,[8][9][10]. Notably, most of these cases involved MNV type 2, similar to our patient's condition.…”

“…There is significant evidence linking type 2 MNV and BALAD [8,9]. Palmieri et al suggested intense exudation and inflammation in certain MNVs might pull on the photoreceptors' myoid, causing a split [10]. Additionally, SRHM observed in this case could be a mix of inflammatory fibrin and photoreceptor debris, potentially contributing to subretinal fibrosis [1,2,5].…”

“…BALAD is a nonspecific feature observed in various choroidal conditions, such as acute Vogt-Koyanagi-Harada (VKH) syndrome, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), posterior scleritis, tubercular choroidal granuloma, panuveitis, choroidal metastases from lung and breast tumors, or acute nonpenetrating ocular trauma [3][4][5][6][7]. It has also been reported in Bacillary layer setachment (BALAD) in neovascular age-related macular degeneration -three years' follow-up of a case study www.journals.viamedica.pl/ophthalmology_journal central serous chorioretinopathy after photodynamic therapy (PDT) [3], acute idiopathic maculopathy [4], or nAMD [8][9][10]. BALAD can change during treatment, often improving as clinical conditions improve.…”

Advanced Research in Age-Related Macular Degeneration: Special Issue

“…One study [16] aimed to report the clinical and multimodal imaging findings of patients with neovascular AMD who developed bacillary layer detachment (BALAD). This finding is not commonly described in the literature.…”