Bacille Calmette-Guerin (BCG) complications in children with severe combined immunodeficiency (SCID)

Barkai, Galia; Somech, Raz; Stauber, Tali; Barziali, Aviv; Greenberger, Shoshana

doi:10.1080/23744235.2019.1628354

Cited by 14 publications

(6 citation statements)

References 17 publications

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“…The time of emerging BCG complications were between 15 days and 45 days. Our BCGitis ratio after transplantation was 50% of SCID patients which was slightly higher than other data collected in Turkey, 8,17 but it was of a value near to other reported studies 18,19 . After transplantation, BCGitis can also be accepted as the first sign of lymphocyte engraftment.…”

Section: Discussioncontrasting

confidence: 49%

“…transplantation was 50% of SCID patients which was slightly higher than other data collected in Turkey, 8,17 but it was of a value near to other reported studies. 18,19 After transplantation, BCGitis can also be accepted as the first sign of lymphocyte engraftment. In other words, inflammatory nodules are seen at vaccination site on engraftment days in SCID patients.…”

Section: Discussionmentioning

confidence: 99%

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Primary immunodeficiencies: HSCT experiences of a single center in Turkey

Çipe

Aksoy

Aydoğdu

et al. 2021

Pediatric Transplantation

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Background Primary immunodeficiency diseases (PID) are characterized by the occurrence of frequent infections and are caused by many genetic defects. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment option for the majority of PID. As a Pediatric Hematology‐Oncology‐Immunology Transplantation Unit, we wanted to present our HSCT experience regarding treatment of primary immunodeficiency diseases. Methods 58 patients were included in the study between January 2014 and June 2019. We searched 9/10 or 10/10 matched‐related donor (MRD) firstly, in the absence of fully matched‐related donor. We screened matched unrelated donor (MUD) from donor banks. MRD was used in 24 (41.3%) patients, MUD in 20 (34.4%) patients, and haploidentical donors in 14 (24.1%) patients. Demographic data, HSCT characteristics, and outcome were evaluated. While 16 patients had severe combined immunodeficiency (SCID), the remaining was non‐SCID. Results Of the 58 patients, 38 were male and 20 were female. Median age at transplantation was 12 months (range: 2.5–172 months). Combined immunodeficiencies consisted 67.2% of patients. Mean follow‐up time was 27 months (6 months–5 years). Median neutrophil, lymphocyte, and thrombocyte engraftment days were similar in comparison of both donor type and stem cell source. The most common complication was acute GvHD in 15 (25.8%) patients. In total, five patients (31%) belonging to the SCID group and 10 patients (23.8%) belonging to the non‐SCID group died. Our total mortality rate was 15 (25.8%) in all patients. Conclusions We would like to present our HSCT experiences as a pediatric immunology transplantation center. Existing severe infections before transplantation period, BCGitis, and CMV are important issues of transplantation in Turkey. However, the follow‐up time is shorter than some studies, our results regarding complications and survival are similar to previous reports.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Primary immunodeficiencies: HSCT experiences of a single center in Turkey

Çipe

Aksoy

Aydoğdu

et al. 2021

Pediatric Transplantation

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“…However, a lower, although not statistically significant, specificity, was observed in tNGS as compared to Xpert, which probably due to the detection of dead bacilli in patients with a history of treated TB [ 15 ]. It's worth noting that two SCID were diagnosed as mycobacterium bovis by tNGS, and Bacille Calmette-Guerin (BCG) derived disease has been described in infants with SCID [ 16 , 17 ]. Besides, 1 central nervous system infection and 1 sepsis cases were also diagnosed as TB by tNGS, and it is possible that the positive result may have been caused by nonspecific amplification, which should be confirmed by another molecular assay.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of tNGS vs Xpert MTB/RIF in childhood TB

Zheng,

Yang,

Wang

et al. 2024

Heliyon

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“…Patients who received BCG vaccine and do not have adverse reactions should also receive prophylaxis with isoniazid and anti-tuberculosis treatment in case of BCG complications ( Table 2 , Table 3 ). 36 …”

Section: Prophylaxis For Combined Immunodeficienciesmentioning

confidence: 99%