“…An analysis of comparative studies of BCG-ID and BCG-PC leads to the following conclusions: stimulation of a DTH skin test response and the production of cytokines associated with Th1 lymphocytes are more reliable with BCG-ID; 4,12,49 low dosages of the BCG vaccine are unreliable for inducing protective responses, as assessed by IF-γ production; 42 it is probable that the differences between the results found when comparing the two techniques are the result of the lower dosage inoculated percutaneously; [6][7][8][9][30][31][32][33][34][35][36][37][38][39][40][41][42] adverse events associated with BCG are most common in association with poor administration technique; 4,9,18 the use of scarring to test whether the vaccine has taken is only of use after BCG-ID since BCG-PC does not leave scars; 9,18,19 the presence of scars should be verified during infancy since the scar reduces in size over the years; 27,29 BCG-ID gives better protection against the more severe forms of the disease, which principally occur d u r i n g c h i l d h o o d , s u c h a s m e n i n g i t i s tuberculosa; 2,3,32,33,35 to date, there is no evidence to prove that revaccination is effective for increasing the levels of protection against tuberculosis afforded to adolescents and adults. 28,33,41,47 Recommendations In Brazil, increased vaccination coverage with BC...…”