Bacillus cereus Invasive Infections in Preterm Neonates: an Up-to-Date Review of the Literature

Lotte, Romain; Chevalier, Alicia; Boyer, Laurent; Ruimy, Raymond

doi:10.1128/cmr.00088-21

Cited by 23 publications

(15 citation statements)

References 121 publications

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“…According to previous reports [42], the fluorescence intensity of NPN could indirectly reflect the integrity of E. coli outer membrane (OM). NPN emits weak fluorescence in a hydrophilic environment, but emits sharply strong fluorescence when entering a hydrophobic environment such as the OM of E. coli.…”

Section: Antibacterial Mechanismmentioning

confidence: 83%

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Visible light-regulated cationic polymer coupled with photodynamic inactivation as an effective tool for pathogen and biofilm elimination

Wang

Shi

et al. 2022

J Nanobiotechnol

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Background Pathogenic microorganism pollution has been a challenging public safety issue, attracting considerable scientific interest. A more problematic aspect of this phenomenon is that planktonic bacteria exacerbate biofilm formation. There is an overwhelming demand for developing ultra-efficient, anti-drug resistance, and biocompatibility alternatives to eliminate stubborn pathogenic strains and biofilms. Results The present work aims to construct a visible light-induced anti-pathogen agents to ablate biofilms using the complementary merits of ROS and cationic polymers. The photosensitizer chlorin e6-loaded polyethyleneimine-based micelle (Ce6-TPP-PEI) was constructed by an amphiphilic dendritic polymer (TPP-PEI) and physically loaded with photosensitizer chlorin e6. Cationic polymers can promote the interaction between photosensitizer and Gram-negative bacteria, resulting in enhanced targeting of PS and lethality of photodynamic therapy, and remain active for a longer duration to prevent bacterial re-growth when the light is turned off. As expected, an eminent antibacterial effect was observed on the Gram-negative Escherichia coli, which is usually insensitive to photosensitizers. Surprisingly, the cationic polymer and photodynamic combination also exert significant inhibitory and ablative effects on fungi and biofilms. Subsequently, cell hemolysis assessments suggested its good biocompatibility. Conclusions Given the above results, the platform developed in this work is an efficient and safe tool for public healthcare and environmental remediation.

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Section: Antibacterial Mechanismmentioning

confidence: 83%

“…Bacillus species also cause a wide variety of infections, and they are significant pathogens in humans with increasing frequency [42]. Therefore, B. subtilis was chosen as a typical Gram-positive bacterial model to explore the antibacterial ability of Ce6-TPP-PEI and TPP-PEI (4a, c).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Visible light-regulated cationic polymer coupled with photodynamic inactivation as an effective tool for pathogen and biofilm elimination

Wang

Shi

et al. 2022

J Nanobiotechnol

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“…B. cereus is increasingly recognised as a pathogen of significance in the neonatal population. A recent review of the 145 reported cases of neonatal B. cereus cases to date describes the spectrum of disease in neonates to include bacteraemia, meningoencephalitis, pneumonia, tracheal ulceration, skin/wound infection and septic arthritis, with 80% of cases occurring in premature infants 3. Invasive respiratory infection has been described, with necrosis of the lung parenchyma and upper airway found on postmortem examinations in premature neonates 4 5 .…”

Section: Introductionmentioning

confidence: 99%

NeonatalBacillus cereus: an unusual case of congenital pneumonia requiring ECMO

Anderson,

Patel,

Hargadon-Lowe

2024

BMJ Case Rep

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A term neonate presented with cyanosis from birth, with refractory hypoxaemia despite intubation, administration of 100% oxygen and inhaled nitric oxide. Structural congenital heart disease was excluded. He developed profuse pulmonary haemorrhage at 6 hours of life with worsening hypoxia and was transferred to a paediatric intensive care unit (PICU) for initiation of veno-venous extracorporeal membrane oxygenation (vvECMO). Endotracheal aspirates from both the birth hospital and the PICU were positive forBacillus cereus, with all other investigations finding no alternative cause for his presentation. Of note, mother was a practising veterinarian raising another potential source of exposure to this pathogen. A full recovery occurred after a total of 5 days of vvECMO, 13 days of ventilation and 20 days of PICU stay.

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“…Bacillus cereus consists of large, sporulating Gram-positive, rod-shaped aerobic or facultative anaerobic bacteria that are widespread in the environment (LOTTE et al, 2022). Microorganisms are ubiquitous and can contaminate various food products, leading to transient colonization of the human gut (GROSH, 1978).…”

Section: Introductionmentioning

confidence: 99%

Bovine abortion due to Bacillus cereus in Midwest Brazil

et al. 2023

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Bacillus cereus is a Gram-positive bacterium commonly reported in soils and plants that occupy various ecological habitats, and the main source of contamination for cattle is silage. This report described a case of fetal loss associated with B. cereus infection in a cow. An 8-month-old, Nelore female bovine fetus from a beef farm was submitted for necropsy. A gross examination revealed fibrinous pleuropneumonia and fibrin exudation on the liver surface. The morphological diagnosis was restricted to the lungs and liver. In the lungs there was fibrinosuppurative pleuropneumonia associated with numerous aggregates of rod-shaped bacteria. In the liver there was moderate focally extensive fibrinous peri hepatitis.The lungs, liver, thoracic, and abomasal fluid cultures yielded pure cultures of B. cereus, indicating that these bacteria should be recognized as a cause of bovine abortion in fetuses that macroscopically present fibrin in the abdominal and thoracic cavity.

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Bacillus cereus Invasive Infections in Preterm Neonates: an Up-to-Date Review of the Literature

Cited by 23 publications

References 121 publications

Visible light-regulated cationic polymer coupled with photodynamic inactivation as an effective tool for pathogen and biofilm elimination

Visible light-regulated cationic polymer coupled with photodynamic inactivation as an effective tool for pathogen and biofilm elimination

NeonatalBacillus cereus: an unusual case of congenital pneumonia requiring ECMO

Bovine abortion due to Bacillus cereus in Midwest Brazil

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