Back Cover: Mono‐ and bis‐edaravone adducts formed in the presence of vanillin in an aqueous solution

Abstract

DOI: https://doi.org/10.1002/sscp.202200031 The cover picture shows how the reactivity of the phenyl‐pyrazolone drug edaravone in the presence of vanillin, used here as a model aromatic aldehyde. Edaravone (EDA) is an injectable drug commonly used to treat amyotrophic lateral sclerosis, acting as a free radical scavenger to reduce oxidative damages in cells. In addition, EDA can form adducts with aromatic aldehydes, such as 6‐formylpterin and vanillin, for example. Here, the mono‐ and bis‐adducts formed in the presence of vanillin in an aqueous solution have been separated and fully identified. The kinetic of the reaction has been analyzed and, for the first time, a partial reversibility of the reaction has been evidenced.