Back Cover: Transesterification of Non‐Activated Esters Promoted by Small Molecules Mimicking the Active Site of Hydrolases (Angew. Chem. Int. Ed. 35/2022)

Abstract

As malls ynthetic artificial enzyme … …isable to accomplish, for the first time,the transesterification of non-activated esters under neutral and mild conditions.Inspired by the catalytic machinery of chymotrypsin and N-terminal hydrolases,J osØ J. Garrido-Gonzµlez, ngel L. Fuentes de Arriba et al. show in their Research Article (e202206072) that as mall molecule which mimics the catalytic triad and oxyanion hole of hydrolases can emulate in at est tube the catalytic properties of hydrolytic enzymes.