Back to school: challenges and rewards of engaging young children in scientific research

Stocks, Janet; Lum, Sooky

doi:10.1136/archdischild-2015-310347

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…However, it is imperative that the instruments developed are thoroughly tested and piloted in the intended population. As highlighted 415 from this and other studies, children and young people's active involvement and contribution early in development can facilitate the construction of age-appropriate instruments that are consistent with their competence, abilities and understanding (Stocks and Lum, 2016).…”

Section: Practicesmentioning

confidence: 99%

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children’s Acceptability of Oral Formulations (CALF) Study

Ranmal¹,

Cram

Tuleu³

2016

International Journal of Pharmaceutics

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A lack of evidence to guide the design of age-appropriate and acceptable dosage forms has been a longstanding knowledge gap in paediatric formulation development. The Children's Acceptability of Oral Formulations (CALF) study captured end-user perceptions and practices with a focus on solid oral dosage forms, namely tablets, capsules, chewables, orodispersibles, multiparticulates (administered with food) and mini-tablets (administered directly into the mouth). A rigorous development and testing phase produced age-adapted questionnaires as measurement tools with strong evidence of validity and reliability. Overall, 590 school children and adolescents, and 428 adult caregivers were surveyed across hospitals and various community settings. Attitudes towards dosage forms primarily differed based on age and prior use. Positive attitudes to tablets and capsules increased with age until around 14 years. Preference was seen for chewable and orodispersible preparations across ages, while multiparticulates were seemingly less favourable. Overall, 59.6% of school children reported willingness to take 10mm diameter tablets, although only 32.1% of caregivers perceived this size to be suitable. While not to be taken as prescriptive guidance, the results of this study provide some evidence towards rational dosage form design, as well as methodological approaches to help design tools for further evaluation of acceptability within paediatric studies.

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Section: Practicesmentioning

confidence: 99%

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children’s Acceptability of Oral Formulations (CALF) Study

Ranmal¹,

Cram

Tuleu³

2016

International Journal of Pharmaceutics

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“…Regulators now underline the importance of children’s participation in research to understand their opinions about medicines [ 4 ]. Methods for involving children in research are still in development, and to allow their participation, it is important to create effective and age-appropriate tools that are compatible with their understanding and abilities [ 2 , 13 ]. In this study, an online survey created in collaboration with EPTRI PPI and YPAG groups and piloted with several children groups from different countries was used to involve the public in formulation advisory activities and to collect information that could facilitate the development of better paediatric dosage forms.…”

Section: Discussionmentioning

confidence: 99%

Children’s Preferences for Oral Dosage Forms and Their Involvement in Formulation Research via EPTRI (European Paediatric Translational Research Infrastructure)

et al. 2021

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The paucity of evidence-based data on formulation characteristics preferred by the children is known to limit the design of tailored paediatric dosage forms. The European Paediatric Translational Research Infrastructure (EPTRI) commissioned a study to evaluate children’s dosage forms perceived preferences in some European countries and explore the feasibility of using the young persons advisory groups (YPAGs) to involve children in formulation research. An online, age-adapted survey was developed and translated into six languages. The survey link was disseminated across seven European countries: Albania, Italy, the Netherlands, and Dutch-speaking part of Belgium, Romania, Spain, and the United Kingdom. Respondents’ (n = 1172) perceived preferences for oral dosage forms primarily differed based on age, health status, and experience. Conventional dosage forms, i.e., liquid (35%), tablets (19%), and capsules (14%), were the most selected. Liquid was widely selected by children less than 12 years and by those healthy and taking medicines rarely. Monolithic solid forms were mostly chosen by adolescents and by children with a chronic disease taking medicines frequently. There was a clear lack of familiarity with more novel dosage forms (e.g., orodispersible films and granules). Noteworthy, granules were not appreciated, particularly by adolescents (52.8%). To rationalise the creation of paediatric formulations, it is important to involve children as active stakeholders and to apply tools assessing children’s perspectives on medicines to inform acceptable dosage form development from the start.

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“…This is particularly evident in relation to the OHC of hospitalized children (Blevins 2011). Whilst some lessons may be drawn from the adult literature, the transferability of findings to the paediatric cohort is unclear, as it is well recognised that children are not small adults, but have unique needs (Stocks & Lum, 2016).…”

Section: Introductionmentioning

confidence: 99%

An exploration of student nurses’ views of oral health care in the hospitalised child: A qualitative study

Morley

Lotto

2019

Nurse Education in Practice

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Back to school: challenges and rewards of engaging young children in scientific research

Cited by 4 publications

References 24 publications

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children’s Acceptability of Oral Formulations (CALF) Study

Age-appropriate and acceptable paediatric dosage forms: Insights into end-user perceptions, preferences and practices from the Children’s Acceptability of Oral Formulations (CALF) Study

Children’s Preferences for Oral Dosage Forms and Their Involvement in Formulation Research via EPTRI (European Paediatric Translational Research Infrastructure)

An exploration of student nurses’ views of oral health care in the hospitalised child: A qualitative study

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